Search Results - "Kato, Itaru"

Development of dual-targeted CAR T-cell therapy by Kato, Itaru

“…Chimeric antigen receptor T-cell therapy (CAR-T-cell therapy) has revolutionized the treatment of relapsed and refractory hematological malignancies. Targeting…”
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Flow Cytometric Detection of G0 in Live Cells by Hoechst 33342 and Pyronin Y Staining by Eddaoudi, Ayad, Canning, Stephanie Louise, Kato, Itaru

“…Hoechst 33342 and Pyronin Y double staining can be used to measure DNA and RNA content in live cells by flow cytometry. Quiescent cells at G0 phase have the…”
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Transient remission of chronic active EBV infection after chemotherapy alone by Akazawa, Ryo, Otsuka, Saki, Kato, Itaru, Imadome, Ken‐Ichi, Takita, Junko

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CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia by Imayoshi, Natsuki, Yoshioka, Makoto, Tanaka, Kuniaki, Yang, Shyh-Ming, Akahane, Koshi, Toda, Yuki, Hosogi, Shigekuni, Inukai, Takeshi, Okada, Seiji, Maloney, David J., Nakahata, Tatsutoshi, Takita, Junko, Kato, Itaru, Ashihara, Eishi

“…Acute lymphoblastic leukemia with chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene (MLL-r ALL) remains an incurable disease. Thus,…”
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Efficacy and safety of tisagenlecleucel in Japanese pediatric and young adult patients with relapsed/refractory B cell acute lymphoblastic leukemia by Hiramatsu, Hidefumi, Adachi, Souichi, Umeda, Katsutsugu, Kato, Itaru, Eldjerou, Lamis, Agostinho, Andrea Chassot, Natsume, Kazuto, Tokushige, Kota, Watanabe, Yoko, Grupp, Stephan A.

“…Tisagenlecleucel is an autologous T cell genetically modified ex vivo using a lentiviral vector encoding an anti-CD19 chimeric antigen receptor. Here, we…”
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Pazopanib for second recurrence of osteosarcoma in pediatric patients by Umeda, Katsutsugu, Kato, Itaru, Saida, Satoshi, Okamoto, Takeshi, Adachi, Souchi

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Successful re‐administration of all‐trans retinoic acid after acute pancreatitis by Daifu, Tomoo, Umeda, Katsutsugu, Takahashi, Hiroyuki, Hiramatsu, Hidefumi, Kato, Itaru

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CD146 is a potential immunotarget for neuroblastoma by Obu, Satoshi, Umeda, Katsutsugu, Ueno, Hiroo, Sonoda, Mari, Tasaka, Keiji, Ogata, Hideto, Kouzuki, Kagehiro, Nodomi, Seishiro, Saida, Satoshi, Kato, Itaru, Hiramatsu, Hidefumi, Okamoto, Tatsuya, Ogawa, Eri, Okajima, Hideaki, Morita, Ken, Kamikubo, Yasuhiko, Kawaguchi, Koji, Watanabe, Kenichiro, Iwafuchi, Hideto, Yagyu, Shigeki, Iehara, Tomoko, Hosoi, Hajime, Nakahata, Tatsutoshi, Adachi, Souichi, Uemoto, Shinji, Heike, Toshio, Takita, Junko

“…Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to arise from neural crest‐derived immature cells. The prognosis of patients…”
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Temozolomide and etoposide combination for the treatment of relapsed osteosarcoma by Akazawa, Ryo, Umeda, Katsutsugu, Saida, Satoshi, Kato, Itaru, Hiramatsu, Hidefumi, Sakamoto, Akio, Arakawa, Yoshiki, Sumiyoshi, Shinji, Okamoto, Takeshi, Moritake, Hiroshi, Adachi, Souichi, Takita, Junko

“…The prognosis of patients with relapsed osteosarcoma is extremely poor and the optimal treatment remains to be identified. Here, we retrospectively analysed…”
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Ponatinib in pediatric patients with Philadelphia chromosome-positive leukemia: a retrospective survey of the Japan Children’s Cancer Group by Kodama, Yuichi, Sato, Atsushi, Kato, Keisuke, Sakaguchi, Hirotoshi, Kato, Motohiro, Kawasaki, Hirohide, Hiramatsu, Hidefumi, Kato, Itaru, Taga, Takashi, Shimada, Hiroyuki

“…Ponatinib is effective in adults with Philadelphia chromosome-positive (Ph+) leukemia, resistant or intolerant to second-generation tyrosine kinase inhibitors,…”
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Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors by Hamabata, Takayuki, Umeda, Katsutsugu, Kouzuki, Kagehiro, Tanaka, Takayuki, Daifu, Tomoo, Nodomi, Seishiro, Saida, Satoshi, Kato, Itaru, Baba, Shiro, Hiramatsu, Hidefumi, Osawa, Mitsujiro, Niwa, Akira, Saito, Megumu K., Kamikubo, Yasuhiko, Adachi, Souichi, Hashii, Yoshiko, Shimada, Akira, Watanabe, Hiroyoshi, Osafune, Kenji, Okita, Keisuke, Nakahata, Tatsutoshi, Watanabe, Kenichiro, Takita, Junko, Heike, Toshio

“…Shwachman–Diamond syndrome (SDS), an autosomal recessive disorder characterized by bone marrow failure, exocrine pancreatic insufficiency, and skeletal…”
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Influence of post-transplant mucosal-associated invariant T cell recovery on the development of acute graft-versus-host disease in allogeneic bone marrow transplantation by Kawaguchi, Koji, Umeda, Katsutsugu, Hiejima, Eitaro, Iwai, Atsushi, Mikami, Masamitsu, Nodomi, Seishiro, Saida, Satoshi, Kato, Itaru, Hiramatsu, Hidefumi, Yasumi, Takahiro, Nishikomori, Ryuta, Kondo, Tadakazu, Takaori-Kondo, Akifumi, Heike, Toshio, Adachi, Souichi

“…Mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) cells are T cell subpopulations that possess innate-like properties. We examined…”
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Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia by Isobe, Tomoya, Takagi, Masatoshi, Sato-Otsubo, Aiko, Nishimura, Akira, Nagae, Genta, Yamagishi, Chika, Tamura, Moe, Tanaka, Yosuke, Asada, Shuhei, Takeda, Reina, Tsuchiya, Akiho, Wang, Xiaonan, Yoshida, Kenichi, Nannya, Yasuhito, Ueno, Hiroo, Akazawa, Ryo, Kato, Itaru, Mikami, Takashi, Watanabe, Kentaro, Sekiguchi, Masahiro, Seki, Masafumi, Kimura, Shunsuke, Hiwatari, Mitsuteru, Kato, Motohiro, Fukuda, Shiro, Tatsuno, Kenji, Tsutsumi, Shuichi, Kanai, Akinori, Inaba, Toshiya, Shiozawa, Yusuke, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Kotecha, Rishi S., Cruickshank, Mark N., Ishikawa, Fumihiko, Morio, Tomohiro, Eguchi, Mariko, Deguchi, Takao, Kiyokawa, Nobutaka, Arakawa, Yuki, Koh, Katsuyoshi, Aoki, Yuki, Ishihara, Takashi, Tomizawa, Daisuke, Miyamura, Takako, Ishii, Eiichi, Mizutani, Shuki, Wilson, Nicola K., Göttgens, Berthold, Miyano, Satoru, Kitamura, Toshio, Goyama, Susumu, Yokoyama, Akihiko, Aburatani, Hiroyuki, Ogawa, Seishi, Takita, Junko

“…KMT2A -rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity…”
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The combination of ruxolitinib and Bcl-2/Mcl-1 inhibitors has a synergistic effect on leukemic cells carrying a SPAG9::JAK2 fusion by Mayumi, Azusa, Tomii, Toshihiro, Kanayama, Takuyo, Mikami, Takashi, Tanaka, Kuniaki, Ueno, Hiroo, Yoshida, Hideki, Kato, Itaru, Kawamura, Machiko, Nakahata, Tatsutoshi, Takita, Junko, Hosoi, Hajime, Imamura, Toshihiko

“…JAK2 rearrangements can occur in Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). Here, we performed functional analysis of the…”
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A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors by Niwa, Akira, Heike, Toshio, Umeda, Katsutsugu, Oshima, Koichi, Kato, Itaru, Sakai, Hiromi, Suemori, Hirofumi, Nakahata, Tatsutoshi, Saito, Megumu K

“…Elucidating the in vitro differentiation of human embryonic stem (ES) and induced pluripotent stem (iPS) cells is important for understanding both normal and…”
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The first Japanese biobank of patient‐derived pediatric acute lymphoblastic leukemia xenograft models by Tanaka, Kuniaki, Kato, Itaru, Dobashi, Yuu, Imai, Jun‐ichi, Mikami, Takashi, Kubota, Hirohito, Ueno, Hiroo, Ito, Mamoru, Ogawa, Seishi, Nakahata, Tatsutoshi, Takita, Junko, Toyoda, Hidemi, Ogawa, Chitose, Adachi, Souichi, Watanabe, Shinya, Goto, Hiroaki

“…A lack of practical resources in Japan has limited preclinical discovery and testing of therapies for pediatric relapsed and refractory acute lymphoblastic…”
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Case Report: A Case of Epstein-Barr Virus-Associated Acute Liver Failure Requiring Hematopoietic Cell Transplantation After Emergent Liver Transplantation by Nakajima, Koji, Hiejima, Eitaro, Nihira, Hiroshi, Kato, Kentaro, Honda, Yoshitaka, Izawa, Kazushi, Kawabata, Naoko, Kato, Itaru, Ogawa, Eri, Sonoda, Mari, Okamoto, Tatsuya, Okajima, Hideaki, Yasumi, Takahiro, Takita, Junko

“…Hepatic manifestations of Epstein-Barr virus (EBV) infection are relatively common, mild, and self-limiting. Although fulminant hepatic failure has been…”
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Author Correction: Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors by Hamabata, Takayuki, Umeda, Katsutsugu, Kouzuki, Kagehiro, Tanaka, Takayuki, Daifu, Tomoo, Nodomi, Seishiro, Saida, Satoshi, Kato, Itaru, Baba, Shiro, Hiramatsu, Hidefumi, Osawa, Mitsujiro, Niwa, Akira, Saito, Megumu K., Kamikubo, Yasuhiko, Adachi, Souichi, Hashii, Yoshiko, Shimada, Akira, Watanabe, Hiroyoshi, Osafune, Kenji, Okita, Keisuke, Nakahata, Tatsutoshi, Watanabe, Kenichiro, Takita, Junko, Heike, Toshio

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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PAX5 alterations in an infant case of KMT2A‐rearranged leukemia with lineage switch by Nakajima, Koji, Kubota, Hirohito, Kato, Itaru, Isobe, Kiyotaka, Ueno, Hiroo, Kozuki, Kagehiro, Tanaka, Kuniaki, Kawabata, Naoko, Mikami, Takashi, Tamefusa, Kosuke, Nishiuchi, Ritsuo, Saida, Satoshi, Umeda, Katsutsugu, Hiramatsu, Hidefumi, Adachi, Souichi, Takita, Junko

“…Lineage switch is a rare event at leukemic relapse. While mostly known to occur in KMT2A‐rearranged infant leukemia, the underlying mechanism is yet to be…”
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BRAF V600E -positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis by Kudo, Ko, Toki, Tsutomu, Kanezaki, Rika, Tanaka, Tatsuhiko, Kamio, Takuya, Sato, Tomohiko, Sasaki, Shinya, Imamura, Masaru, Imai, Chihaya, Ando, Kumiko, Kakuda, Harumi, Doi, Takehiko, Kawaguchi, Hiroshi, Irie, Masahiro, Sasahara, Yoji, Tamura, Akihiro, Hasegawa, Daiichiro, Itakura, Yosuke, Watanabe, Kenichiro, Sakamoto, Kenichi, Shioda, Yoko, Kato, Motohiro, Kudo, Kazuko, Fukano, Reiji, Sato, Atsushi, Yagasaki, Hiroshi, Kanegane, Hirokazu, Kato, Itaru, Umeda, Katsutsugu, Adachi, Souichi, Kataoka, Tatsuki, Kurose, Akira, Nakazawa, Atsuko, Terui, Kiminori, Ito, Etsuro

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