Search Results - "Katkar, Gajanan D."

Parsing the Role of PPARs in Macrophage Processes by Toobian, Daniel, Ghosh, Pradipta, Katkar, Gajanan D

“…Cells are richly equipped with nuclear receptors, which act as ligand-regulated transcription factors. Peroxisome proliferator activated receptors (PPARs),…”
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An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease by Ghosh, Pradipta, Katkar, Gajanan D., Shimizu, Chisato, Kim, Jihoon, Khandelwal, Soni, Tremoulet, Adriana H., Kanegaye, John T., Bocchini, Joseph, Das, Soumita, Burns, Jane C., Sahoo, Debashis

“…Multisystem inflammatory syndrome in children (MIS-C) is an illness that emerged amidst the COVID-19 pandemic but shares many clinical features with the…”
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Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease by Sahoo, Debashis, Swanson, Lee, Sayed, Ibrahim M., Katkar, Gajanan D., Ibeawuchi, Stella-Rita, Mittal, Yash, Pranadinata, Rama F., Tindle, Courtney, Fuller, Mackenzie, Stec, Dominik L., Chang, John T., Sandborn, William J., Das, Soumita, Ghosh, Pradipta

“…Modeling human diseases as networks simplify complex multi-cellular processes, helps understand patterns in noisy data that humans cannot find, and thereby…”
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NETosis and lack of DNase activity are key factors in Echis carinatus venom-induced tissue destruction by Katkar, Gajanan D., Sundaram, Mahalingam S., NaveenKumar, Somanathapura K., Swethakumar, Basavarajaiah, Sharma, Rachana D., Paul, Manoj, Vishalakshi, Gopalapura J., Devaraja, Sannaningaiah, Girish, Kesturu S., Kemparaju, Kempaiah

“…Indian Echis carinatus bite causes sustained tissue destruction at the bite site. Neutrophils, the major leukocytes in the early defence process, accumulate at…”
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COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis by Sinha, Saptarshi, Castillo, Vanessa, Espinoza, Celia R., Tindle, Courtney, Fonseca, Ayden G., Dan, Jennifer M., Katkar, Gajanan D., Das, Soumita, Sahoo, Debashis, Ghosh, Pradipta

“…In the aftermath of Covid-19, some patients develop a fibrotic lung disease, i.e., post-COVID-19 lung disease (PCLD), for which we currently lack insights into…”
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Reply to ‘Evidence that neutrophils do not promote Echis carinatus venom-induced tissue destruction’ by Kemparaju, Kempaiah, Girish, Kesturu S., Katkar, Gajanan D.

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Publisher Correction: An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease by Ghosh, Pradipta, Katkar, Gajanan D., Shimizu, Chisato, Kim, Jihoon, Khandelwal, Soni, Tremoulet, Adriana H., Kanegaye, John T., Bocchini, Joseph, Das, Soumita, Burns, Jane C., Sahoo, Debashis

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AI-guided discovery of the invariant host response to viral pandemics by Sahoo, Debashis, Katkar, Gajanan D., Khandelwal, Soni, Behroozikhah, Mahdi, Claire, Amanraj, Castillo, Vanessa, Tindle, Courtney, Fuller, MacKenzie, Taheri, Sahar, Rogers, Thomas F., Beutler, Nathan, Ramirez, Sydney I., Rawlings, Stephen A., Pretorius, Victor, Smith, Davey M., Burton, Dennis R., Alexander, Laura E. Crotty, Duran, Jason, Crotty, Shane, Dan, Jennifer M., Das, Soumita, Ghosh, Pradipta

“…Coronavirus Disease 2019 (Covid-19) continues to challenge the limits of our knowledge and our healthcare system. Here we sought to define the host immune…”
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Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease by Katkar, Gajanan D., Sayed, Ibrahim M., Anandachar, Mahitha Shree, Castillo, Vanessa, Vidales, Eleadah, Toobian, Daniel, Usmani, Fatima, Sawires, Joseph R., Leriche, Geoffray, Yang, Jerry, Sandborn, William J., Das, Soumita, Sahoo, Debashis, Ghosh, Pradipta

“…A computational platform, Boolean network explorer (BoNE), has recently been developed to infuse AI-enhanced precision into drug discovery; it enables…”
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TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin by Swanson, Lee, Katkar, Gajanan D., Tam, Julian, Pranadinata, Rama F., Chareddy, Yogitha, Coates, Jane, Anandachar, Mahitha Shree, Castillo, Vanessa, Olson, Joshua, Nizet, Victor, Kufareva, Irina, Das, Soumita, Ghosh, Pradipta

“…Sensing of pathogens by Toll-like receptor 4 (TLR4) induces an inflammatory response; controlled responses confer immunity but uncontrolled responses cause…”
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Diverse gut pathogens exploit the host engulfment pathway via a conserved mechanism by Anandachar, Mahitha Shree, Roy, Suchismita, Sinha, Saptarshi, Boadi, Agyekum, Katkar, Gajanan D., Ghosh, Pradipta

“…Macrophages clear infections by engulfing and digesting pathogens within phagolysosomes. Pathogens escape this fate by engaging in a molecular arms race; they…”
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Machine learning identifies signatures of macrophage reactivity and tolerance that predict disease outcomes by Ghosh, Pradipta, Sinha, Saptarshi, Katkar, Gajanan D., Vo, Daniella, Taheri, Sahar, Dang, Dharanidhar, Das, Soumita, Sahoo, Debashis

“…Single-cell transcriptomic studies have greatly improved organ-specific insights into macrophage polarization states are essential for the initiation and…”
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A first-in-class anticancer dual HDAC2/FAK inhibitors bearing hydroxamates/benzamides capped by pyridinyl-1,2,4-triazoles by Mustafa, Muhamad, Abd El-Hafeez, Amer Ali, Abdelhamid, Dalia, Katkar, Gajanan D., Mostafa, Yaser A., Ghosh, Pradipta, Hayallah, Alaa M., Abuo-Rahma, Gamal El-Din A.

“…Novel 5-pyridinyl-1,2,4-triazoles were designed as dual inhibitors of histone deacetylase 2 (HDAC2) and focal adhesion kinase (FAK). Compounds 5d, 6a, 7c, and…”
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Research into the Causes of Venom-Induced Mortality and Morbidity Identifies New Therapeutic Opportunities by Girish, Kesturu S, Katkar, Gajanan D, Harrison, Robert A, Kemparaju, Kempaiah

“…Snakebite primarily affects rural subsistent farming populations in underdeveloped and developing nations. The annual number of deaths (100,000) and physical…”
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Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides by Muntjewerff, Elke M., Tang, Kechun, Lutter, Lisanne, Christoffersson, Gustaf, Nicolasen, Mara J. T., Gao, Hong, Katkar, Gajanan D., Das, Soumita, ter Beest, Martin, Ying, Wei, Ghosh, Pradipta, El Aidy, Sahar, Oldenburg, Bas, van den Bogaart, Geert, Mahata, Sushil K.

“…Aim A “leaky” gut barrier has been implicated in the initiation and progression of a multitude of diseases, for example, inflammatory bowel disease (IBD),…”
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Inhibition of Echis carinatus venom by DNA, a promising therapeutic molecule for snakebite management by Swethakumar, Basavarajaiah, NaveenKumar, Somanathapura K., Katkar, Gajanan D., Girish, Kesturu S., Kemparaju, Kempaiah

“…E. carinatus bite is a serious threat to South-Asian countries including India, as it causes the highest number of deaths and debilitating sustained tissue…”
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Oxidative stress-induced methemoglobinemia is the silent killer during snakebite: a novel and strategic neutralization by melatonin by Sharma, Rachana D., Katkar, Gajanan D., Sundaram, Mahalingam S., Paul, Manoj, NaveenKumar, Somanathapura K., Swethakumar, Basavarajaiah, Hemshekhar, Mahadevappa, Girish, Kesturu S., Kemparaju, Kempaiah

“…Oxidative stress‐induced methemoglobinemia remained an untouched area in venom pharmacology till date. This study for the first time explored the potential of…”
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Melatonin inhibits snake venom and antivenom induced oxidative stress and augments treatment efficacy by Sharma, Rachana D., Katkar, Gajanan D., Sundaram, Mahalingam S., Swethakumar, Basavarajaiah, Girish, Kesturu S., Kemparaju, Kempaiah

“…Snakebite is a neglected health hazard. Its patho-physiology has largely been focused on systemic and local toxicities; whereas, venom and antivenom induced…”
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A living organoid biobank of patients with Crohn’s disease reveals molecular subtypes for personalized therapeutics by Tindle, Courtney, Fonseca, Ayden G., Taheri, Sahar, Katkar, Gajanan D., Lee, Jasper, Maity, Priti, Sayed, Ibrahim M., Ibeawuchi, Stella-Rita, Vidales, Eleadah, Pranadinata, Rama F., Fuller, Mackenzie, Stec, Dominik L., Anandachar, Mahitha Shree, Perry, Kevin, Le, Helen N., Ear, Jason, Boland, Brigid S., Sandborn, William J., Sahoo, Debashis, Das, Soumita, Ghosh, Pradipta

“…Crohn’s disease (CD) is a complex and heterogeneous condition with no perfect preclinical model or cure. To address this, we explore adult stem cell-derived…”
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A first-in-class dual HDAC2/FAK inhibitors bearing hydroxamates/benzamides capped by pyridinyl-1,2,4-triazoles with anticancer activity by Mustafa, Muhamad, Abd El-Hafeez, Amer Ali, Abdelhamid, Dalia, Katkar, Gajanan D., Mostafa, Yaser A., Ghosh, Pradipta, Hayallah, Alaa M., Abuo-Rahma, Gamal El-Din A.

“…Novel 5-pyridinyl-1,2,4-triazoles were designed as dual inhibitors of histone deacetylase 2 (HDAC2) and focal adhesion kinase (FAK). Compounds 5d , 6a , 7c ,…”
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