Search Results - "Katiyar, Shashank"

Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells by Nigam, Nupur, Grover, Abhinav, Goyal, Sukriti, Katiyar, Shashank P, Bhargava, Priyanshu, Wang, Pi-Chao, Sundar, Durai, Kaul, Sunil C, Wadhwa, Renu

“…Embelin, a natural quinone found in the fruits of Embelia ribes, is commonly used in Ayurvedic home medicine for a variety of therapeutic potentials including…”
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Molecular dynamics simulations and experimental studies reveal differential permeability of withaferin-A and withanone across the model cell membrane by Wadhwa, Renu, Yadav, Neetu Singh, Katiyar, Shashank P., Yaguchi, Tomoko, Lee, Chohee, Ahn, Hyomin, Yun, Chae-Ok, Kaul, Sunil C., Sundar, Durai

“…Poor bioavailability due to the inability to cross the cell membrane is one of the major reasons for the failure of a drug in clinical trials. We have used…”
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2, 3-Dihydro-3β-methoxy Withaferin-A Lacks Anti-Metastasis Potency: Bioinformatics and Experimental Evidences by Chaudhary, Anupama, Kalra, Rajkumar S., Malik, Vidhi, Katiyar, Shashank P., Sundar, Durai, Kaul, Sunil C., Wadhwa, Renu

“…Withaferin-A is a withanolide, predominantly present in Ashwagandha ( Withania somnifera ). It has been shown to possess anticancer activity in a variety of…”
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Withanone-rich combination of Ashwagandha withanolides restricts metastasis and angiogenesis through hnRNP-K by Gao, Ran, Shah, Navjot, Lee, Jung-Sun, Katiyar, Shashank P, Li, Ling, Oh, Eonju, Sundar, Durai, Yun, Chae-Ok, Wadhwa, Renu, Kaul, Sunil C

“…Ashwagandha is an important herb used in the Indian system of traditional home medicine, Ayurveda. Alcoholic extract (i-Extract) from its leaves and its…”
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Probing the molecular mechanism of hypericin-induced parasite death provides insight into the role of spermidine beyond redox metabolism in Leishmania donovani by Singh, Shalini, Sarma, Shyamali, Katiyar, Shashank P, Das, Mousumi, Bhardwaj, Ruchika, Sundar, Durai, Dubey, Vikash Kumar

“…Hypericin, a natural compound from Hypericum perforatum (St. John's wort), has been identified as a specific inhibitor of Leishmania donovani spermidine…”
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Computational Structure-Based De Novo Design of Hypothetical Inhibitors against the Anti- Inflammatory Target COX-2 by Dhanjal, Jaspreet Kaur, Sreenidhi, Anith Kumar, Bafna, Khushboo, Katiyar, Shashank Prakash, Goyal, Sukriti, Grover, Abhinav, Sundar, Durai

“…Cyclooxygenase-2 (COX-2) produces prostaglandins in inflamed tissues and hence has been considered as an important target for the development of…”
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Fragment-Based Ligand Designing by Katiyar, Shashank P, Malik, Vidhi, Kumari, Anjani, Singh, Kamya, Sundar, Durai

“…Fragment-based drug design strategies have been used in drug discovery since it was first demonstrated using experimental structural biology techniques such as…”
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Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences by Yu, Yue, Katiyar, Shashank P, Sundar, Durai, Kaul, Zeenia, Miyako, Eijiro, Zhang, Zhenya, Kaul, Sunil C, Reddel, Roger R, Wadhwa, Renu

“…Maintenance of telomere length is the most consistent attribute of cancer cells. Tightly connected to their capacity to overcome replicative mortality, it is…”
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Mixed Inhibition of cPEPCK by Genistein, Using an Extended Binding Site Located Adjacent to Its Catalytic Cleft by Katiyar, Shashank Prakash, Jain, Arpit, Dhanjal, Jaspreet Kaur, Sundar, Durai

“…Cytosolic phosphoenolpyruvate carboxykinase (cPEPCK) is a critical enzyme involved in gluconeogenesis, glyceroneogenesis and cataplerosis. cPEPCK converts…”
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Blocking protein kinase C signaling pathway: mechanistic insights into the anti-leishmanial activity of prospective herbal drugs from Withania somnifera by Grover, Abhinav, Katiyar, Shashank Prakash, Jeyakanthan, Jeyaraman, Dubey, Vikash Kumar, Sundar, Durai

“…Leishmaniasis is caused by several species of leishmania protozoan and is one of the major vector-born diseases after malaria and sleeping sickness. Toxicity…”
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Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization by Saxena, Nishant, Katiyar, Shashank P, Liu, Ye, Grover, Abhinav, Gao, Ran, Sundar, Durai, Kaul, Sunil C, Wadhwa, Renu

“…Bcl-2 family of proteins consists of both pro-apoptotic and anti-apoptotic members that control cellular apoptosis. They predominantly reside in the…”
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Wild type p53 function in p53Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence by Sundar, Durai, Yu, Yue, Katiyar, Shashank P, Putri, Jayarani F, Dhanjal, Jaspreet Kaur, Wang, Jia, Sari, Anissa Nofita, Kolettas, Evangelos, Kaul, Sunil C, Wadhwa, Renu

“…Background Tumor suppressor p53 protein is frequently mutated in a large majority of cancers. These mutations induce local or global changes in protein…”
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Influence of symmetric and asymmetric alterations of maxillary canine gingival margin on the perception of smile esthetics among orthodontists, dentists, and laypersons by Katiyar, Shashank, Gandhi, Sumit, Sodawala, Javed, Anita, G, Hamdani, Shaheen, Jain, Suyog

“…Introduction: Esthetics is one of the major concerns among people seeking orthodontic treatment, and its perception varies from person to person. Our objective…”
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A leishmaniasis study: Structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase by Grover, Abhinav, Katiyar, Shashank Prakash, Singh, Sanjeev Kumar, Dubey, Vikash Kumar, Sundar, Durai

“…Protozoa Leishmania donovani (Ld) is the main cause of the endemic disease leishmaniasis. Spermidine synthase (SS), an important enzyme in the synthetic…”
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Role of aromatic stack pairing at the catalytic site of gelonin protein by Katiyar, Shashank Prakash, Bakkiyaraj, Dhamodharan, Karutha Pandian, Shunmugiah

“…► This study highlights the importance of π–π interactions at the catalytic site of ribosome inactivating proteins (RIP). ► In silico mutation studies using…”
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Wild type p53 function in p53 Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence by Sundar, Durai, Yu, Yue, Katiyar, Shashank P, Putri, Jayarani F, Dhanjal, Jaspreet Kaur, Wang, Jia, Sari, Anissa Nofita, Kolettas, Evangelos, Kaul, Sunil C, Wadhwa, Renu

“…Tumor suppressor p53 protein is frequently mutated in a large majority of cancers. These mutations induce local or global changes in protein structure thereby…”
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Mechanistic insights into the dual inhibition strategy for checking Leishmaniasis by Grover, Abhinav, Katiyar, Shashank Prakash, Jeyakanthan, Jeyaraman, Dubey, Vikash Kumar, Sundar, Durai

“…Leishmaniasis 1 1 These authors contributed equally. is an endemic disease mainly caused by the protozoan Leishmania donovani (Ld). Polyamines have been…”
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Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells: e0138192 by Nigam, Nupur, Grover, Abhinav, Goyal, Sukriti, Katiyar, Shashank P, Bhargava, Priyanshu, Wang, Pi-Chao, Sundar, Durai, Kaul, Sunil C, Wadhwa, Renu

“…Embelin, a natural quinone found in the fruits of Embelia ribes, is commonly used in Ayurvedic home medicine for a variety of therapeutic potentials including…”
Get full text

Influence of symmetric and asymmetric alterations of maxillary canine gingival margin on the perception of smile esthetics among orthodontists, dentists, and laypersons by Katiyar, Shashank, Gandhi, Sumit, Sodawala, Javed, Anita, G, Hamdani, Shaheen, Jain, Suyog

“…Esthetics is one of the major concerns among people seeking orthodontic treatment, and its perception varies from person to person. Our objective was to…”
Get more information