Search Results - "Kathy Beckingham"

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4 by Böhni, Ruth, Riesgo-Escovar, Juan, Oldham, Sean, Brogiolo, Walter, Stocker, Hugo, Andruss, Bernard F, Beckingham, Kathy, Hafen, Ernst

“…The control of growth is fundamental to the developing metazoan. Here, we show that CHICO, a Drosophila homolog of vertebrate IRS1–4, plays an essential role…”
Get full text

Calmodulin regulation of Drosophila light-activated channels and receptor function mediates termination of the light response in vivo by Scott, K, Sun, Y, Beckingham, K, Zuker, C S

“…Calmodulin (CAM) participates in a variety of intracellular transduction processes by modulating signaling molecules in response to calcium changes. We report…”
Get full text

Regulation of RYR1 Activity by Ca2+ and Calmodulin by Rodney, George G, Williams, Barbara Y, Strasburg, Gale M, Beckingham, Kathy, Hamilton, Susan L

“…The skeletal muscle calcium release channel (RYR1) is a Ca2+-binding protein that is regulated by another Ca2+-binding protein, calmodulin. The functional…”
Get full text

The Dorothy enhancer has tinman binding sites and drives hopscotch-induced tumor formation by Kimbrell, Deborah A., Hice, Carina, Bolduc, Clare, Kleinhesselink, Kurt, Beckingham, Kathy

Get full text

An Extended Conformation of Calmodulin Induces Interactions between the Structural Domains of Adenylyl Cyclase from Bacillus anthracis to Promote Catalysis by Drum, Chester L., Yan, Shui-Zhong, Sarac, Radmila, Mabuchi, Yasuko, Beckingham, Kathy, Bohm, Andrew, Grabarek, Zenon, Tang, Wei-Jen

“…The edema factor exotoxin produced byBacillus anthracis is an adenylyl cyclase that is activated by calmodulin (CaM) at resting state calcium concentrations in…”
Get full text

Mutations at Lysine 525 of Inducible Nitric-oxide Synthase Affect Its Ca2+-independent Activity by Lee, Shiow-Ju, Beckingham, Kathy, Stull, James T.

“…Calmodulin binding to inducible nitric-oxide synthase may play an important role in its Ca2+-independent activity. Studies of inducible nitric-oxide synthase…”
Get full text

Functional Diversity of Alternatively Spliced Isoforms of Drosophila Ca2+/Calmodulin-dependent Protein Kinase II by GuptaRoy, Bipasha, Beckingham, Kathy, Griffith, Leslie C.

“…Isoforms of calcium/calmodulin-dependent protein kinase II from Drosophila (R1-R6 and R3A) showed differential activation by two series of mutant calmodulins,…”
Get full text

Characterization of Eu(III) binding to a series of calmodulin binding site mutants using laser-induced Eu(III) luminescence spectroscopy by Bruno, JoAnne, Horrocks, William De W., Beckingham, Kathy

“…Laser-induced luminescence techniques were used in a rigorous evaluation of the Eu 3+-binding behavior of a recombinant ( Drosophila melanogaster) calmodulin…”
Get full text

Calmodulin Mediates Calcium-dependent Activation of the Intermediate Conductance KCa Channel,IKCa1 by Fanger, C M, Ghanshani, S, Logsdon, N J, Rauer, H, Kalman, K, Zhou, J, Beckingham, K, Chandy, K G, Cahalan, M D, Aiyar, J

“…Small and intermediate conductance Ca 2+ -activated K + channels play a crucial role in hyperpolarizing the membrane potential of excitable and nonexcitable…”
Get full text

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins by Shen, Yuequan, Lee, Young-Sam, Soelaiman, Sandriyana, Bergson, Pamela, Lu, Dan, Chen, Alice, Beckingham, Kathy, Grabarek, Zenon, Mrksich, Milan, Tang, Wei-Jen

“…Edema factor (EF) and CyaA are calmodulin (CaM)‐activated adenylyl cyclase exotoxins involved in the pathogenesis of anthrax and whooping cough, respectively…”
Get full text

Regulation of RYR1 activity by Ca(2+) and calmodulin by Rodney, G. G., Williams, B. Y., Strasburg, G. M., Beckingham, K., Hamilton, S. L.

“…The skeletal muscle calcium release channel (RYR1) is a Ca(2+)-binding protein that is regulated by another Ca(2+)-binding protein, calmodulin. The functional…”
Get full text

High Affinity Ca2+ Binding Sites of Calmodulin Are Critical for the Regulation of Myosin Iβ Motor Function by Zhu, Tong, Beckingham, Kathy, Ikebe, Mitsuo

“…We coexpressed myosin Iβ heavy chain with three different calmodulin mutants in which the two Ca2+-binding sites of the two N-terminal domain (E12Q),…”
Get full text

bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery by Markesich, D C, Gajewski, K M, Nazimiec, M E, Beckingham, K

“…bicaudal was the first Drosophila mutation identified as producing mirror-image pattern duplications along the anteroposterior axis of the embryo. However the…”
Get full text

Drosophila Calmodulin Mutants With Specific Defects in the Musculature or in the Nervous System by Wang, Bo, Sullivan, Kathleen M. C, Beckingham, Kathy

“…We have studied lethal mutations in the single calmodulin gene (Cam) of Drosophila to gain insight into the in vivo functions of this important calcium sensor…”
Get full text

The Carboxy-Terminal Calcium Binding Sites of Calmodulin Control Calmodulin's Switch from an Activator to an Inhibitor of RYR1 by Rodney, George G, Krol, Jack, Williams, Barbara, Beckingham, Kathy, Hamilton, Susan L

“…Calcium and calmodulin both regulate the skeletal muscle calcium release channel, also known as the ryanodine receptor, RYR1. Ca2+-free calmodulin…”
Get full text

Movement of calmodulin between cells in the ovary and embryo of drosophila by Andruss, Bernard F., Bolduc, Clare, Beckingham, Kathy

“…Calmodulin (CaM) is an essential component of calcium signaling in multicellular organisms. We used null mutations of the Drosophila CaM gene (Cam) in…”
Get full text

High Affinity Ca2+ Binding Sites of Calmodulin Are Critical for the Regulation of Myosin Iβ Motor Function by Tong Zhu, Kathy Beckingham, Mitsuo Ikebe

“…We coexpressed myosin Iβ heavy chain with three different calmodulin mutants in which the two Ca 2+ -binding sites of the two N-terminal domain (E12Q),…”
Get full text

Calmodulin UAS-constructs and the in vivo roles of calmodulin: Analysis of a muscle-specific phenotype by Wang, Bo, Bolduc, Clare, Beckingham, Kathy

“…The vast range of intracellular processes that are regulated by Ca super(2+) fluxes has only recently begun to be appreciated. The Ca super(2+)-binding protein…”
Get full text

Calcium Binding Sites of Calmodulin and Electron Transfer by Neuronal Nitric Oxide Synthase by Stevens-Truss, Regina, Beckingham, Kathy, Marletta, Michael A

“…Although binding of calmodulin (CaM) to neuronal nitric oxide synthase (nNOS) has been demonstrated to act as the trigger necessary for electron transfer and…”
Get full text

Regulation of RYR1 Activity by Ca 2+ and Calmodulin by Rodney, George G., Williams, Barbara Y., Strasburg, Gale M., Beckingham, Kathy, Hamilton, Susan L.

Get full text