Search Results - "Kathryn M. Ramsey"

NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging by Levine, Daniel C., Hong, Heekyung, Weidemann, Benjamin J., Ramsey, Kathryn M., Affinati, Alison H., Schmidt, Mark S., Cedernaes, Jonathan, Omura, Chiaki, Braun, Rosemary, Lee, Choogon, Brenner, Charles, Peek, Clara Bien, Bass, Joseph

“…Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of NAD+, yet whether changes…”
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Time-restricted feeding mitigates obesity through adipocyte thermogenesis by Hepler, Chelsea, Weidemann, Benjamin J, Waldeck, Nathan J, Marcheva, Biliana, Cedernaes, Jonathan, Thorne, Anneke K, Kobayashi, Yumiko, Nozawa, Rino, Newman, Marsha V, Gao, Peng, Shao, Mengle, Ramsey, Kathryn M, Gupta, Rana K, Bass, Joseph

“…Misalignment of feeding rhythms with the light-dark cycle leads to disrupted peripheral circadian clocks and obesity. Conversely, restricting feeding to the…”
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Improved transformation efficiency of group A Streptococcus by inactivation of a type I restriction modification system by Finn, Meredith B, Ramsey, Kathryn M, Tolliver, Hunter J, Dove, Simon L, Wessels, Michael R

“…Streptococcus pyogenes or group A Streptococcus (GAS) is a leading cause of bacterial pharyngitis, skin and soft tissue infections, life-threatening invasive…”
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Control of a programmed cell death pathway in Pseudomonas aeruginosa by an antiterminator by Peña, Jennifer M., Prezioso, Samantha M., McFarland, Kirsty A., Kambara, Tracy K., Ramsey, Kathryn M., Deighan, Padraig, Dove, Simon L.

“…In Pseudomonas aeruginosa the alp system encodes a programmed cell death pathway that is switched on in a subset of cells in response to DNA damage and is…”
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Identification of Group A Streptococcus Genes Directly Regulated by CsrRS and Novel Intermediate Regulators by Finn, Meredith B, Ramsey, Kathryn M, Dove, Simon L, Wessels, Michael R

“…Adaptation of group A Streptococcus (GAS) to its human host is mediated by two-component systems that transduce external stimuli to regulate bacterial…”
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Tn-Seq reveals hidden complexity in the utilization of host-derived glutathione in Francisella tularensis by Ramsey, Kathryn M, Ledvina, Hannah E, Tresko, Tenayaann M, Wandzilak, Jamie M, Tower, Catherine A, Tallo, Thomas, Schramm, Caroline E, Peterson, S Brook, Skerrett, Shawn J, Mougous, Joseph D, Dove, Simon L

“…Host-derived glutathione (GSH) is an essential source of cysteine for the intracellular pathogen Francisella tularensis. In a comprehensive transposon…”
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Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth by Eshraghi, Aria, Kim, Jungyun, Walls, Alexandra C., Ledvina, Hannah E., Miller, Cheryl N., Ramsey, Kathryn M., Whitney, John C., Radey, Matthew C., Peterson, S. Brook, Ruhland, Brittany R., Tran, Bao Q., Goo, Young Ah, Goodlett, David R., Dove, Simon L., Celli, Jean, Veesler, David, Mougous, Joseph D.

“…The intracellular bacterial pathogen Francisella tularensis causes tularemia, a zoonosis that can be fatal. The type VI secretion system (T6SS) encoded by the…”
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Klf15 Orchestrates Circadian Nitrogen Homeostasis by Jeyaraj, Darwin, Scheer, Frank A.J.L., Ripperger, Jürgen A., Haldar, Saptarsi M., Lu, Yuan, Prosdocimo, Domenick A., Eapen, Sam J., Eapen, Betty L., Cui, Yingjie, Mahabeleshwar, Ganapathi H., Lee, Hyoung-gon, Smith, Mark A., Casadesus, Gemma, Mintz, Eric M., Sun, Haipeng, Wang, Yibin, Ramsey, Kathryn M., Bass, Joseph, Shea, Steven A., Albrecht, Urs, Jain, Mukesh K.

“…Diurnal variation in nitrogen homeostasis is observed across phylogeny. But whether these are endogenous rhythms, and if so, molecular mechanisms that link…”
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self-lysis pathway that enhances the virulence of a pathogenic bacterium by McFarland, Kirsty A, Emily L. Dolben, Michele LeRoux, Tracy K. Kambara, Kathryn M. Ramsey, Robin L. Kirkpatrick, Joseph D. Mougous, Deborah A. Hogan, Simon L. Dove

“…In mammalian cells, programmed cell death (PCD) plays important roles in development, in the removal of damaged cells, and in fighting bacterial infections…”
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Ubiquitous promoter-localization of essential virulence regulators in Francisella tularensis by Ramsey, Kathryn M, Osborne, Melisa L, Vvedenskaya, Irina O, Su, Cathy, Nickels, Bryce E, Dove, Simon L

“…Francisella tularensis is a Gram-negative bacterium whose ability to replicate within macrophages and cause disease is strictly dependent upon the coordinate…”
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Pervasive Targeting of Nascent Transcripts by Hfq by Kambara, Tracy K., Ramsey, Kathryn M., Dove, Simon L.

“…Hfq is an RNA chaperone and an important post-transcriptional regulator in bacteria. Using chromatin immunoprecipitation coupled with high-throughput DNA…”
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A Ribosomal Protein Homolog Governs Gene Expression and Virulence in a Bacterial Pathogen by Trautmann, Hannah S, Ramsey, Kathryn M

“…The molecular machine necessary for protein synthesis, the ribosome, is generally considered constitutively functioning and lacking any inherent regulatory…”
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Circadian NAD(P)(H) cycles in cell metabolism by Levine, Daniel C., Ramsey, Kathryn M., Bass, Joseph

“…Intrinsic circadian clocks are present in all forms of photosensitive life, enabling daily anticipation of the light/dark cycle and separation of energy…”
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Circadian clocks and metabolism by Marcheva, Biliana, Ramsey, Kathryn M, Peek, Clara B, Affinati, Alison, Maury, Eleonore, Bass, Joseph

“…Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the…”
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Widespread targeting of nascent transcripts by RsmA in Pseudomonas aeruginosa by Gebhardt, Michael J., Kambara, Tracy K., Ramsey, Kathryn M., Dove, Simon L.

“…In the opportunistic pathogen Pseudomonas aeruginosa, RsmA is an RNA-binding protein that plays critical roles in the control of virulence, interbacterial…”
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Ribosome heterogeneity results in leader sequence-mediated regulation of protein synthesis in Francisella tularensis by Trautmann, Hannah S, Schmidt, Sierra S, Gregory, Steven T, Ramsey, Kathryn M

“…Although ribosomes are generally examined in aggregate, ribosomes can be heterogenous in composition. Evidence is accumulating that changes in ribosome…”
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Nutrient sensing and the circadian clock by Peek, Clara B, Ramsey, Kathryn M, Marcheva, Biliana, Bass, Joseph

“…The circadian system synchronizes behavioral and physiologic processes with daily changes in the external light–dark cycle, optimizing energetic cycles with…”
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A response regulator promotes Francisella tularensis intramacrophage growth by repressing an anti‐virulence factor by Ramsey, Kathryn M., Dove, Simon L.

“…Summary The orphan response regulator PmrA is essential for the intramacrophage growth and survival of Francisella tularensis. PmrA was thought to promote…”
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Structural Basis for Virulence Activation of Francisella tularensis by Travis, Brady A., Ramsey, Kathryn M., Prezioso, Samantha M., Tallo, Thomas, Wandzilak, Jamie M., Hsu, Allen, Borgnia, Mario, Bartesaghi, Alberto, Dove, Simon L., Brennan, Richard G., Schumacher, Maria A.

“…The bacterium Francisella tularensis (Ft) is one of the most infectious agents known. Ft virulence is controlled by a unique combination of transcription…”
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Polyphosphate Kinase Antagonizes Virulence Gene Expression in Francisella tularensis by Rohlfing, Amy E, Ramsey, Kathryn M, Dove, Simon L

“…The alarmone ppGpp is a critical regulator of virulence gene expression in In this intracellular pathogen, ppGpp is thought to work in concert with the…”
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