One-pot Synthesis of Fully Substituted Pyrimidines Using Amidine and Ketene Dithioacetals as Synthons and Their Antimicrobial Activity
A simple, convenient, and efficient one‐pot synthesis of fully substituted pyrimidines was developed by cyclocondensation of α‐oxo ketene dithioacetals with amidine in the presence of potassium carbonate in good yield. Structures of all the newly synthesized compounds were elucidated by elemental an...
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| Published in: | Journal of heterocyclic chemistry Vol. 52; no. 3; pp. 751 - 755 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Hoboken
Blackwell Publishing Ltd
01-05-2015
Wiley Subscription Services, Inc |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | A simple, convenient, and efficient one‐pot synthesis of fully substituted pyrimidines was developed by cyclocondensation of α‐oxo ketene dithioacetals with amidine in the presence of potassium carbonate in good yield. Structures of all the newly synthesized compounds were elucidated by elemental analysis and spectral analysis. All the newly synthesized compounds are tested toward different microorganisms. |
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| Bibliography: | ark:/67375/WNG-DV90CRGW-0 istex:CEA012BD1983541EDFDA37CB127F74F9D453A170 ArticleID:JHET2184 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0022-152X 1943-5193 |
| DOI: | 10.1002/jhet.2184 |