Search Results - "Kathman, Steven J"

Population pharmacokinetic–pharmacodynamic modeling of PB2452, a monoclonal antibody fragment being developed as a ticagrelor reversal agent, in healthy volunteers by Kathman, Steven J., Wheeler, Jeffery J., Bhatt, Deepak L., Arnold, Susan E., Lee, John S.

“…PB2452, a neutralizing monoclonal antibody fragment that binds the antiplatelet drug ticagrelor with high affinity, is being developed as a ticagrelor reversal…”
Get full text

Prevalence estimates for MS in the United States and evidence of an increasing trend for women by NOONAN, Curtis W, KATHMAN, Steven J, WHITE, Mary C

“…The purpose of this study was to provide current age-, sex-, and region-specific MS prevalence estimates and to identify trends using the National Health…”
Get full text

Effects of Exposure to Low Levels of Environmental Cadmium on Renal Biomarkers by Noonan, Curtis W., Sarasua, Sara M., Campagna, Dave, Kathman, Steven J., Lybarger, Jeffrey A., Mueller, Patricia W.

“…We conducted a study among residents of a small community contaminated with heavy metals from a defunct zinc smelter and residents from a comparison community…”
Get full text

A phase 2, randomized study of SB‐485232, rhIL‐18, in patients with previously untreated metastatic melanoma by Tarhini, Ahmad A., Millward, Michael, Mainwaring, Paul, Kefford, Richard, Logan, Ted, Pavlick, Anna, Kathman, Steven J., Laubscher, Kevin H., Dar, Mohammed M., Kirkwood, John M.

“…BACKGROUND: Phase 1 studies demonstrated evidence of recombinant human IL‐18 (rhIL‐18)‐mediated immunomodulatory and clinical activity, and defined a…”
Get full text

Combining estimates from multiple early studies to obtain estimates of response: using shrinkage estimates to obtain estimates of response by Kathman Jr, Steven J., Hale, Michael D.

“…Development of anti‐cancer therapies usually involve small to moderate size studies to provide initial estimates of response rates before initiating larger…”
Get full text

Study of cardiovascular disease biomarkers among tobacco consumers. Part 3: evaluation and comparison with the US National Health and Nutrition Examination Survey by Marano, Kristin M., Kathman, Steven J., Jones, Bobbette A., Nordskog, Brian K., Brown, Buddy G., Borgerding, Michael F.

“…Abstract Cardiovascular disease (CVD) biomarkers of biological effect (BoBE), including hematologic biomarkers, serum lipid-related biomarkers, other serum…”
Get full text

Cadmium exposure and tobacco consumption: Biomarkers and risk assessment by Marano, Kristin M., Naufal, Ziad S., Kathman, Steven J., Bodnar, Joy A., Borgerding, Michael F., Garner, Charles D., Wilson, Cody L.

“…► Blood and urine Cd levels in cigarette smokers were higher than in smokeless tobacco consumers and non-consumers of tobacco. ► Blood and urine Cd levels in…”
Get full text

A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors by Burris, Howard A., Jones, Suzanne F., Williams, Daphne D., Kathman, Steven J., Hodge, Jeffrey P., Pandite, Lini, Ho, Peter T. C., Boerner, Scott A., LoRusso, Patricia

“…Summary Purpose To establish the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), safety, and pharmacokinetic profile of ispinesib when administered…”
Get full text

Arsenic exposure and tobacco consumption: Biomarkers and risk assessment by Marano, Kristin M., Naufal, Ziad S., Kathman, Steven J., Bodnar, Joy A., Borgerding, Michael F., Wilson, Cody L.

“…► Urine arsenic levels were not different in cigarette smokers, smokeless tobacco consumers, and non-consumers of tobacco. ► Urine arsenic levels associated…”
Get full text

Differential exposure biomarker levels among cigarette smokers and smokeless tobacco consumers in the National Health and Nutrition Examination Survey 1999-2008 by Naufal, Ziad S., Marano, Kristin M., Kathman, Steven J., Wilson, Cody L.

“…Assessment of biomarkers is an appropriate way to estimate exposure to cigarette mainstream smoke and smokeless tobacco (SLT) constituents in tobacco…”
Get full text

Bayesian population PK-PD model for ispinesib/docetaxel combination-induced myelosuppression by Kathman, Steven J, Williams, Daphne H, Hodge, Jeffrey P, Dar, Mohammed

“…Purpose Ispinesib, a kinesin spindle protein inhibitor, blocks assembly of a functional mitotic spindle, leading to G2/M arrest. Docetaxel promotes tubulin…”
Get full text

A Bayesian statistical analysis of mouse dermal tumor promotion assay data for evaluating cigarette smoke condensate by Kathman, Steven J., Potts, Ryan J., Ayres, Paul H., Harp, Paul R., Wilson, Cody L., Garner, Charles D.

“…The mouse dermal assay has long been used to assess the dermal tumorigenicity of cigarette smoke condensate (CSC). This mouse skin model has been developed for…”
Get full text

Ambient hydrogen sulfide, total reduced sulfur, and hospital visits for respiratory diseases in northeast Nebraska, 1998-2000 by Campagna, Dave, Kathman, Steven J, Pierson, Ray, Inserra, Steven G, Phifer, Betty L, Middleton, Dannie C, Zarus, Gregory M, White, Mary C

“…This analysis examined associations between total reduced sulfur (TRS) and hydrogen sulfide (H(2)S) levels, and hospital visits for respiratory disease among…”
Get full text

Influence of environmental zinc on the association between environmental and biological measures of lead in children by Noonan, Curtis W, Kathman, Steven J, Sarasua, Sara M, White, Mary C

“…Exposure to lead, a common environmental contaminant found at hazardous waste sites, has been associated with adverse health effects to humans. Zinc, a…”
Get full text

An Expansion of the Probability Mass Function that may be used to Improve Poisson Approximations by Kathman, Steven J.

“…SummaryRandom variables defined on the natural numbers may often be approximated by Poisson variables. Just as normal approximations may be improved by the…”
Get full text

Improving Poisson approximations through tilting and expansion by Kathman, Steven J., Terrell, George R.

“…Random variables defined on the natural numbers may often be approximated by Poisson variables. Just as normal approximations may be improved by saddlepoint…”
Get full text

Poisson approximation by constrained exponential tilting by Kathman, Steven J., Terrell, George R.

“…Poisson approximations are important whenever interest is in some counting process. Barbour et al. (Poisson Approximation, Oxford University Press, New York,…”
Get full text