Search Results - "Kathleen Pestal"

Regulation of the nucleic acid-sensing Toll-like receptors by Lind, Nicholas A., Rael, Victoria E., Pestal, Kathleen, Liu, Bo, Barton, Gregory M.

“…Many of the ligands for Toll-like receptors (TLRs) are unique to microorganisms, such that receptor activation unequivocally indicates the presence of…”
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Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development by Pestal, Kathleen, Funk, Cory C., Snyder, Jessica M., Price, Nathan D., Treuting, Piper M., Stetson, Daniel B.

“…Mutations in ADAR, which encodes the ADAR1 RNA-editing enzyme, cause Aicardi-Goutières syndrome (AGS), a severe autoimmune disease associated with an aberrant…”
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Intracellular Nucleic Acid Detection in Autoimmunity by Crowl, John T, Gray, Elizabeth E, Pestal, Kathleen, Volkman, Hannah E, Stetson, Daniel B

“…Protective immune responses to viral infection are initiated by innate immune sensors that survey extracellular and intracellular space for foreign nucleic…”
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In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway by Wienert, Beeke, Shin, Jiyung, Zelin, Elena, Pestal, Kathleen, Corn, Jacob E

“…Clustered, regularly interspaced, short palindromic repeat (CRISPR)-CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental research and has…”
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RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry by Jung, Heiyoun, Hsiung, Benjamin, Pestal, Kathleen, Procyk, Emily, Raulet, David H

“…The NKG2D stimulatory receptor expressed by natural killer cells and T cell subsets recognizes cell surface ligands that are induced on transformed and…”
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Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples by Jennifer R Hamilton, Elizabeth C Stahl, Connor A Tsuchida, Enrique Lin-Shiao, C Kimberly Tsui, Kathleen Pestal, Holly K Gildea, Lea B Witkowsky, Erica A Moehle, Shana L McDevitt, Matthew McElroy, Amanda Keller, Iman Sylvain, Ariana Hirsh, Alison Ciling, Alexander J Ehrenberg, Bradley R Ringeisen, Garth Huberty, Fyodor D Urnov, Petros Giannikopoulos, Jennifer A Doudna, IGI SARS-CoV-2 Consortium

“…Saliva is an attractive specimen type for asymptomatic surveillance of COVID-19 in large populations due to its ease of collection and its demonstrated utility…”
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Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus by Ehrenberg, Alexander J, Moehle, Erica A, Brook, Cara E, Doudna Cate, Andrew H, Witkowsky, Lea B, Sachdeva, Rohan, Hirsh, Ariana, Barry, Kerrie, Hamilton, Jennifer R, Lin-Shiao, Enrique, McDevitt, Shana, Valentin-Alvarado, Luis, Letourneau, Kaitlyn N, Hunter, Lauren, Keller, Amanda, Pestal, Kathleen, Frankino, Phillip A, Murley, Andrew, Nandakumar, Divya, Stahl, Elizabeth C, Tsuchida, Connor A, Gildea, Holly K, Murdock, Andrew G, Hochstrasser, Megan L, O'Brien, Elizabeth, Ciling, Alison, Tsitsiklis, Alexandra, Worden, Kurtresha, Dugast-Darzacq, Claire, Hays, Stephanie G, Barber, Colin C, McGarrigle, Riley, Lam, Emily K, Ensminger, David C, Bardet, Lucie, Sherry, Carolyn, Harte, Anna, Nicolette, Guy, Giannikopoulos, Petros, Hockemeyer, Dirk, Petersen, Maya, Urnov, Fyodor D, Ringeisen, Bradley R, Boots, Mike, Doudna, Jennifer A

“…Regular surveillance testing of asymptomatic individuals for SARS-CoV-2 has been center to SARS-CoV-2 outbreak prevention on college and university campuses…”
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LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples by Stahl, Elizabeth C, Gopez, Allan R, Tsuchida, Connor A, Fan, Vinson B, Moehle, Erica A, Witkowsky, Lea B, Hamilton, Jennifer R, Lin-Shiao, Enrique, McElroy, Matthew, McDevitt, Shana L, Ciling, Alison, Tsui, C Kimberly, Pestal, Kathleen, Gildea, Holly K, Keller, Amanda, Sylvain, Iman A, Williams, Clara, Hirsh, Ariana, Ehrenberg, Alexander J, Kantor, Rose, Metzger, Matthew, Nelson, Kara L, Urnov, Fyodor D, Ringeisen, Bradley R, Giannikopoulos, Petros, Doudna, Jennifer A

“…Clinical and surveillance testing for the SARS-CoV-2 virus relies overwhelmingly on RT-qPCR-based diagnostics, yet several popular assays require 2-3 separate…”
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Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples by Hamilton, Jennifer R, Stahl, Elizabeth C, Tsuchida, Connor A, Lin-Shiao, Enrique, Tsui, C Kimberly, Pestal, Kathleen, Gildea, Holly K, Witkowsky, Lea B, Moehle, Erica A, McDevitt, Shana L, McElroy, Matthew, Keller, Amanda, Sylvain, Iman, Hirsh, Ariana, Ciling, Alison, Ehrenberg, Alexander J, Ringeisen, Bradley R, Huberty, Garth, Urnov, Fyodor D, Giannikopoulos, Petros, Doudna, Jennifer A

“…Saliva is an attractive specimen type for asymptomatic surveillance of COVID-19 in large populations due to its ease of collection and its demonstrated utility…”
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Monitoring SARS-CoV-2 incidence and seroconversion among university students and employees: a longitudinal cohort study in California, June–August 2020 by Hunter, Lauren A, Wyman, Stacia, Packel, Laura J, Facente, Shelley N, Li, Yi, Harte, Anna, Nicolette, Guy, Di Germanio, Clara, Busch, Michael P, Reingold, Arthur L, Petersen, Maya L, Urnov, Fyodor, McDevitt, Shana, Hirsch, Ariana, Ehrenberg, Alexander, Doudna, Jennifer A, Amen, M, Barry, Kerrie W, Boyle, John M, Brook, Cara E, Choo, Seunga, Cornmesser, LT, Dilworth, David J, Fedrigo, Indro, Friedline, Skyler E, Graham, Thomas G W, Green, Ralph, Hamilton, Jennifer R, Hochstrasser, Megan L, Hockemeyer, Dirk, Krishnappa, Netravathi, Lari, Azra, Li, Hanqin, Lin-Shiao, Enrique, Lu, Tianlin, Lyons, Elijah F, Mark, Kevin G, Martell, Lisa Argento, Martins, A Raquel O, Mitchell, Patrick S, Moehle, Erica A, Naca, Christine, Nandakumar, Divya, O’Brien, Elizabeth, Pappas, Derek J, Pestal, Kathleen, Quach, Diana L, Rubin, Benjamin E, Sachdeva, Rohan, Stahl, Elizabeth C, Syed, Abdullah Muhammad, Tan, I-Li, Tollner, Amy L, Tsuchida, Connor A, Kimberly Tsui, C, Turkalo, Timothy K, Bryan Warf, M, Whitney, Oscar N, Witkowsky, Lea B

“…ObjectivesTo identify incident SARS-CoV-2 infections and inform effective mitigation strategies in university settings, we piloted an integrated symptom and…”
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The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity by Gorman, Jacquelyn A, Hundhausen, Christian, Errett, John S, Stone, Amy E, Allenspach, Eric J, Ge, Yan, Arkatkar, Tanvi, Clough, Courtnee, Dai, Xuezhi, Khim, Socheath, Pestal, Kathleen, Liggitt, Denny, Cerosaletti, Karen, Stetson, Daniel B, James, Richard G, Oukka, Mohamed, Concannon, Patrick, Gale, Michael, Buckner, Jane H, Rawlings, David J

“…Single-nucleotide polymorphisms in the gene encoding the cytosolic viral sensor IFIH1 are linked to a variety of autoimmune diseases. Rawlings and colleagues…”
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A selective role of NKG2D in inflammatory and autoimmune diseases by Guerra, Nadia, Pestal, Kathleen, Juarez, Tiffany, Beck, Jennifer, Tkach, Karen, Wang, Lin, Raulet, David H

“…Abstract The NKG2D activating receptor has been implicated in numerous autoimmune diseases. We tested the role of NKG2D in models of autoimmunity and…”
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Isoforms of ADAR1 independently control MDA5-driven autoimmunity and multi-organ development by Pestal, Kathleen, Funk, Cory C, Snyder, Jessica M, Price, Nathan D, Treuting, Piper M, Stetson, Daniel B

“…Abstract Mutations in the ADAR gene that encodes the ADAR1 RNA editing enzyme cause Aicardi-Goutières Syndrome (AGS), a severe autoimmune disease associated…”
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The A946T variant IFIH1 RNA sensor mediates an interferon program that limits viral infection but increases the risk for autoimmunity by Gorman, Jacquelyn A., Hundhausen, Christian, Errett, John S., Stone, Amy E., Allenspach, Eric J., Ge, Yan, Arkatkar, Tanvi, Clough, Courtnee, Dai, Xuezhi, Khim, Socheath, Pestal, Kathleen, Liggitt, Denny, Cerosaletti, Karen, Stetson, Daniel B., James, Richard G., Oukka, Mohamed, Concannon, Patrick, Gale, Michael, Buckner, Jane H., Rawlings, David J.

“…The single nucleotide polymorphism, rs1990760, in the cytosolic viral sensor, IFIH1, results in an amino-acid change (p.A946T) and is associated with multiple…”
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LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples by Elizabeth C. Stahl, Allan R. Gopez, Connor A. Tsuchida, Vinson B. Fan, Erica A. Moehle, Lea B. Witkowsky, Jennifer R. Hamilton, Enrique Lin-Shiao, Matthew McElroy, Shana L. McDevitt, Alison Ciling, C. Kimberly Tsui, Kathleen Pestal, Holly K. Gildea, Amanda Keller, Iman A. Sylvain, Clara Williams, Ariana Hirsh, Alexander J. Ehrenberg, Rose Kantor, Matthew Metzger, Kara L. Nelson, Fyodor D. Urnov, Bradley R. Ringeisen, Petros Giannikopoulos, Jennifer A. Doudna, IGI Testing Consortium

“…Clinical and surveillance testing for the SARS-CoV-2 virus relies overwhelmingly on RT-qPCR-based diagnostics, yet several popular assays require 2–3 separate…”
Get full text