Search Results - "Kathleen M. Mulder"

Knockdown of c-Fos suppresses the growth of human colon carcinoma cells in athymic mice by Pandey, Manoj K., Liu, Guangming, Cooper, Timothy K., Mulder, Kathleen M.

“…Here we have investigated whether inhibition of c‐Fos expression in RKO human colon carcinoma cells (HCCCs) would result in reduced TGFβ1 expression and…”
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Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells by Jin, Qunyan, Liu, Guangming, Domeier, Phillip P, Ding, Wei, Mulder, Kathleen M

“…We have previously described a novel modulator of the actin cytoskeleton that also regulates Ras and mitogen-activated protein kinase activities in…”
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km23‐1/DYNLRB1 regulation of MEK/ERK signaling and R‐Ras in invasive human colorectal cancer cells by Raza, Asif, Pandey, Madhu S., Jin, Qunyan, Mulder, Kathleen M.

“…We previously found that km23‐1/DYNLRB1 is required for transforming growth factor‐β (TGFβ) production through Ras/ERK pathways in TGFβ‐sensitive epithelial…”
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Structure and Dynamics of the Homodimeric Dynein Light Chain km23 by Ilangovan, Udayar, Ding, Wei, Zhong, Yan, Wilson, Christina L., Groppe, Jay C., Trbovich, James T., Zúñiga, Jorge, Demeler, Borries, Tang, Qian, Gao, Guofeng, Mulder, Kathleen M., Hinck, Andrew P.

“…km23 (96 residues, 11 kDa) is the mammalian ortholog of Drosophila roadblock, the founding member of LC7/robl/km23 class of dynein light chains. km23 has been…”
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The TGFβ Receptor-interacting Protein km23-1/DYNLRB1 Plays an Adaptor Role in TGFβ1 Autoinduction via Its Association with Ras by Jin, Qunyan, Ding, Wei, Mulder, Kathleen M.

“…Background: The TGFβ receptor-interacting protein km23-1 plays an important role in TGFβ signal transduction in TGFβ-sensitive epithelial cells. Results: The…”
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Role of Ras and Mapks in TGFβ signaling by Mulder, Kathleen M

“…Normal signaling by TGFβ, in the absence of serum or exogenous factors, involves a rapid activation of Ras, Erks, and Sapks in proliferating cultures of…”
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Requirement for protein kinase A in the phosphorylation of the TGFβ receptor-interacting protein km23-1 as a component of TGFβ downstream effects by Jin, Qunyan, Zhong, Yan, Mulder, Kathleen M.

“…km23-1 was previously identified as a TGFβ-receptor interacting protein that was phosphorylated on serines after TGFβ stimulation. In the current report, we…”
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Requirement for the Dynein Light Chain km23-1 in a Smad2-dependent Transforming Growth Factor-β Signaling Pathway by Jin, Qunyan, Ding, Wei, Mulder, Kathleen M.

“…We have identified km23-1 as a novel transforming growth factor-β (TGFβ) receptor (TβR)-interacting protein that is also a light chain of the motor protein…”
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Requirement of a dynein light chain in transforming growth factor β signaling in zebrafish ovarian follicle cells by Jin, Qunyan, Gao, Guofeng, Mulder, Kathleen M.

“…► Endogenous zkm23 protein is expressed in zebrafish ovarian follicle cells. ► TGFβ stimulates the phosphorylation of zkm23. ► TGFβ stimulates the recruitment…”
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Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion by Liu, Guangming, Ding, Wei, Neiman, Jill, Mulder, Kathleen M

“…Because increased transforming growth factor-beta (TGFbeta) production by tumor cells contributes to cancer progression through paracrine mechanisms,…”
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A dynein motor attachment complex regulates TGFß/Smad3 signaling by Jin, Qunyan, Gao, Guofeng, Mulder, Kathleen M

“…Our previous results have demonstrated that km23-2 has functions in TGFß signaling that are distinct from those for km23-1. In the current report, we…”
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Role of km23-1 in RhoA/actin-based cell migration by Jin, Qunyan, Pulipati, Nageswara R., Zhou, Weidong, Staub, Cory M., Liotta, Lance A., Mulder, Kathleen M.

“…► We identified several motility-related km23-1-interacting proteins. ► km23-1 overexpression increases actin stress fiber formation in epithelial cells. ►…”
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Overexpression of the dynein light chain km23‐1 in human ovarian carcinoma cells inhibits tumor formation in vivo and causes mitotic delay at prometaphase/metaphase by Pulipati, Nageswara R., Jin, Qunyan, Liu, Xin, Sun, Baodong, Zhao, Yan, Pandey, Manoj K., Huber, Jonathan P., Ding, Wei, Mulder, Kathleen M.

“…km23‐1 is a dynein light chain that was identified as a TGFβ receptor‐interacting protein. To investigate whether km23‐1 controls human ovarian carcinoma cell…”
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c-Fos is required for TGFβ1 production and the associated paracrine migratory effects of human colon carcinoma cells by Liu, Guangming, Ding, Wei, Liu, Xin, Mulder, Kathleen M.

“…In tumor cells that have lost responsiveness to the growth inhibitory effects of transforming growth factor β (TGFβ), increased TGFβ production by the tumor…”
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Requirement of TGF-β receptor-dependent activation of c-Jun N-terminal kinases (JNKs)/stress-activated protein kinases (Sapks) for TGF-β up-regulation of the urokinase-type plasminogen activator receptor by Yue, Jianbo, Sun, Baodong, Liu, Guangming, Mulder, Kathleen M.

“…We have previously demonstrated that activation of the Ras/Mapk pathways is required for transforming growth factor β (TGF‐β) induction of TGF‐β1 expression…”
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A novel transforming growth factor-beta receptor-interacting protein that is also a light chain of the motor protein dynein by Tang, Qian, Staub, Cory M, Gao, Guofeng, Jin, Qunyan, Wang, Zhengke, Ding, Wei, Aurigemma, Rosemarie E, Mulder, Kathleen M

“…The phosphorylated, activated cytoplasmic domains of the transforming growth factor-beta (TGFbeta) receptors were used as probes to screen an expression…”
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A transforming growth factor-β receptor-interacting protein frequently mutated in human ovarian cancer by WEI DING, QIAN TANG, ESPINA, Virginia, LIOTTA, Lance A, MAUGER, David T, MULDER, Kathleen M

“…Ovarian carcinomas, particularly recurrent forms, are frequently resistant to transforming growth factor-beta (TGF-beta)-mediated growth inhibition. However,…”
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km23: a novel TGFbeta signaling target altered in ovarian cancer by Ding, Wei, Mulder, Kathleen M

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TGF β regulation of mitogen-activated protein kinases in human breast cancer cells by Frey, Randall S, Mulder, Kathleen M

“…We demonstrate herein the ability of transforming growth factor-beta-2 (TGF β 2) to potently activate extracellular signal-regulated kinase 2 (ERK2) in the…”
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Requirement of Ras/MAPK Pathway Activation by Transforming Growth Factor β for Transforming Growth Factor β1Production in a Smad-dependent Pathway by Yue, Jianbo, Mulder, Kathleen M.

“…Our previous results have shown that transforming growth factor β (TGFβ) rapidly activates Ras, as well as both ERKs and SAPKs. In order to address the…”
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