Search Results - "Kathiresan, Sekar"

Genetics of coronary artery disease: discovery, biology and clinical translation by Khera, Amit V., Kathiresan, Sekar

“…Key Points Coronary artery disease is a heritable disorder that remains the leading cause of global mortality despite advances in treatment and prevention…”
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Genetics of Common, Complex Coronary Artery Disease by Musunuru, Kiran, Kathiresan, Sekar

“…Coronary artery disease represents the leading cause of death worldwide, sparing no nation, ethnicity, or economic stratum. Coronary artery disease is partly…”
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Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease by Khera, Amit V, Emdin, Connor A, Drake, Isabel, Natarajan, Pradeep, Bick, Alexander G, Cook, Nancy R, Chasman, Daniel I, Baber, Usman, Mehran, Roxana, Rader, Daniel J, Fuster, Valentin, Boerwinkle, Eric, Melander, Olle, Orho-Melander, Marju, Ridker, Paul M, Kathiresan, Sekar

“…Using a polygenic score of DNA sequence polymorphisms, the authors of this study quantified genetic risk and assessed four healthy lifestyle factors. Among…”
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Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions by Fahed, Akl C., Wang, Minxian, Homburger, Julian R., Patel, Aniruddh P., Bick, Alexander G., Neben, Cynthia L., Lai, Carmen, Brockman, Deanna, Philippakis, Anthony, Ellinor, Patrick T., Cassa, Christopher A., Lebo, Matthew, Ng, Kenney, Lander, Eric S., Zhou, Alicia Y., Kathiresan, Sekar, Khera, Amit V.

“…Genetic variation can predispose to disease both through (i) monogenic risk variants that disrupt a physiologic pathway with large effect on disease and (ii)…”
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Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis by Bick, Alexander G., Pirruccello, James P., Griffin, Gabriel K., Gupta, Namrata, Gabriel, Stacey, Saleheen, Danish, Libby, Peter, Kathiresan, Sekar, Natarajan, Pradeep

“…BACKGROUND:Clonal hematopoiesis of indeterminate potential (CHIP) refers to clonal expansion of hematopoietic stem cells attributable to acquired leukemic…”
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Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease by Rosenson, Robert S., MD, Davidson, Michael H., MD, Hirsh, Benjamin J., MD, Kathiresan, Sekar, MD, Gaudet, Daniel, MD, PhD

“…Abstract Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as…”
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Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy by Pirruccello, James P., Bick, Alexander, Wang, Minxian, Chaffin, Mark, Friedman, Samuel, Yao, Jie, Guo, Xiuqing, Venkatesh, Bharath Ambale, Taylor, Kent D., Post, Wendy S., Rich, Stephen, Lima, Joao A. C., Rotter, Jerome I., Philippakis, Anthony, Lubitz, Steven A., Ellinor, Patrick T., Khera, Amit V., Kathiresan, Sekar, Aragam, Krishna G.

“…Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been…”
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Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials by Mega, Jessica L, Dr, Stitziel, Nathan O, Dr, Smith, J Gustav, MD, Chasman, Daniel I, PhD, Caulfield, Mark J, Prof, Devlin, James J, PhD, Nordio, Francesco, PhD, Hyde, Craig L, PhD, Cannon, Christopher P, Prof, Sacks, Frank M, Prof, Poulter, Neil R, Prof, Sever, Peter S, Prof, Ridker, Paul M, Prof, Braunwald, Eugene, Prof, Melander, Olle, Prof, Kathiresan, Sekar, MD, Sabatine, Marc S, Prof

“…Summary Background Genetic variants have been associated with the risk of coronary heart disease. In this study, we tested whether or not a composite of these…”
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Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations by Kalluri, Aditya S, Vellarikkal, Shamsudheen K, Edelman, Elazer R, Nguyen, Lan, Subramanian, Ayshwarya, Ellinor, Patrick T, Regev, Aviv, Kathiresan, Sekar, Gupta, Rajat M

“…BACKGROUND:The cells that form the arterial wall contribute to multiple vascular diseases. The extent of cellular heterogeneity within these populations has…”
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Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease by Jaiswal, Siddhartha, Natarajan, Pradeep, Silver, Alexander J, Gibson, Christopher J, Bick, Alexander G, Shvartz, Eugenia, McConkey, Marie, Gupta, Namrata, Gabriel, Stacey, Ardissino, Diego, Baber, Usman, Mehran, Roxana, Fuster, Valentin, Danesh, John, Frossard, Philippe, Saleheen, Danish, Melander, Olle, Sukhova, Galina K, Neuberg, Donna, Libby, Peter, Kathiresan, Sekar, Ebert, Benjamin L

“…The development of clonal hematopoiesis with increasing age was associated with nearly a doubling in the risk of coronary heart disease, along with an increase…”
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Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood by Khera, Amit V., Chaffin, Mark, Wade, Kaitlin H., Zahid, Sohail, Brancale, Joseph, Xia, Rui, Distefano, Marina, Senol-Cosar, Ozlem, Haas, Mary E., Bick, Alexander, Aragam, Krishna G., Lander, Eric S., Smith, George Davey, Mason-Suares, Heather, Fornage, Myriam, Lebo, Matthew, Timpson, Nicholas J., Kaplan, Lee M., Kathiresan, Sekar

“…Severe obesity is a rapidly growing global health threat. Although often attributed to unhealthy lifestyle choices or environmental factors, obesity is known…”
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Searching for missing heritability: Designing rare variant association studies by Zuk, Or, Schaffner, Stephen F, Samocha, Kaitlin, Do, Ron, Hechter, Eliana, Kathiresan, Sekar, Daly, Mark J, Neale, Benjamin M, Sunyaev, Shamil R, Lander, Eric S

“…Genetic studies have revealed thousands of loci predisposing to hundreds of human diseases and traits, revealing important biological pathways and defining…”
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Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes by Jaiswal, Siddhartha, Fontanillas, Pierre, Flannick, Jason, Manning, Alisa, Grauman, Peter V, Mar, Brenton G, Lindsley, R. Coleman, Mermel, Craig H, Burtt, Noel, Chavez, Alejandro, Higgins, John M, Moltchanov, Vladislav, Kuo, Frank C, Kluk, Michael J, Henderson, Brian, Kinnunen, Leena, Koistinen, Heikki A, Ladenvall, Claes, Getz, Gad, Correa, Adolfo, Banahan, Benjamin F, Gabriel, Stacey, Kathiresan, Sekar, Stringham, Heather M, McCarthy, Mark I, Boehnke, Michael, Tuomilehto, Jaakko, Haiman, Christopher, Groop, Leif, Atzmon, Gil, Wilson, James G, Neuberg, Donna, Altshuler, David, Ebert, Benjamin L

“…About 10% of people older than 70 years of age carry one or more mutations in their hematopoietic cells, and these persons have a higher relative risk of a…”
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Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history by Tada, Hayato, Melander, Olle, Louie, Judy Z, Catanese, Joseph J, Rowland, Charles M, Devlin, James J, Kathiresan, Sekar, Shiffman, Dov

“…Genetic risk scores (GRSs) have been associated with coronary heart disease (CHD) in large studies. We asked whether expanding an established 27-variant GRS…”
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Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week by Khetarpal, Sumeet A, Qamar, Arman, Bick, Alexander G, Fuster, José J, Kathiresan, Sekar, Jaiswal, Siddhartha, Natarajan, Pradeep

“…The incidence of cardiovascular diseases increases with age and is also correlated with increased inflammatory burden. Recently, human genetics provided a new…”
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Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease by Biddinger, Kiran J, Emdin, Connor A, Haas, Mary E, Wang, Minxian, Hindy, George, Ellinor, Patrick T, Kathiresan, Sekar, Khera, Amit V, Aragam, Krishna G

“…Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie,…”
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Genetic determinants of plasma triglycerides by Johansen, Christopher T., Kathiresan, Sekar, Hegele, Robert A.

“…Plasma triglyceride (TG) concentration is reemerging as an important cardiovascular disease risk factor. More complete understanding of the genes and variants…”
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Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia by Khera, Amit V., MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Lawson, Kim S., MS, Bartz, Traci M., MS, Deng, Xuan, MSc, van Leeuwen, Elisabeth M, Natarajan, Pradeep, MD, MMSc, Emdin, Connor A., HBSc, Bick, Alexander G., PhD, Morrison, Alanna C., PhD, Brody, Jennifer A., BA, Gupta, Namrata, PhD, Nomura, Akihiro, MD, Kessler, Thorsten, MD, Duga, Stefano, PhD, Bis, Joshua C., PhD, van Duijn, Cornelia M., PhD, Cupples, L. Adrienne, PhD, Psaty, Bruce, MD, PhD, Rader, Daniel J., MD, Danesh, John, DPhil, Schunkert, Heribert, MD, McPherson, Ruth, MD, Farrall, Martin, MD, Watkins, Hugh, MD, PhD, Lander, Eric, PhD, Wilson, James G., MD, Correa, Adolfo, MD, PhD, Boerwinkle, Eric, PhD, Merlini, Piera Angelica, MD, Ardissino, Diego, MD, Saleheen, Danish, MBBS, PhD, Gabriel, Stacey, PhD, Kathiresan, Sekar, MD

“…Abstract Background Approximately 7% of American adults have severe hypercholesterolemia (untreated low-density lipoprotein [LDL] cholesterol ≥190 mg/dl),…”
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Leveraging Human Genetics to Guide Drug Target Discovery by Stitziel, Nathan O., M.D., Ph.D, Kathiresan, Sekar, M.D

“…Identifying appropriate molecular targets is a critical step in drug development. Despite many advantages, the traditional tools of observational epidemiology…”
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ANGPTL3 Deficiency and Protection Against Coronary Artery Disease by Stitziel, Nathan O., MD, PhD, Khera, Amit V., MD, Wang, Xiao, PhD, Bierhals, Andrew J., MD, MPH, Vourakis, A. Christina, BA, Sperry, Alexandra E., BA, Natarajan, Pradeep, MD, Klarin, Derek, MD, Emdin, Connor A., DPhil, Zekavat, Seyedeh M., BSc, Nomura, Akihiro, MD, Erdmann, Jeanette, PhD, Schunkert, Heribert, MD, Samani, Nilesh J., MD, Kraus, William E., MD, Shah, Svati H., MD, MPH, Yu, Bing, PhD, Boerwinkle, Eric, PhD, Rader, Daniel J., MD, Gupta, Namrata, PhD, Frossard, Philippe M., PhD, Rasheed, Asif, MBBS, Danesh, John, DPhil, Lander, Eric S., PhD, Gabriel, Stacey, PhD, Saleheen, Danish, MBBS, PhD, Musunuru, Kiran, MD, PhD, MPH, Kathiresan, Sekar, MD

“…Abstract Background Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by…”
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