Search Results - "Katherine Yang"

What Do We Know About Remdesivir Drug Interactions? by Yang, Katherine

“…Since the start of the pandemic, information on potential therapeutic options have been rapidly disseminated on an almost daily basis, often with incomplete or…”
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Single extracellular vesicle analysis for early cancer detection by Ferguson, Scott, Yang, Katherine S, Weissleder, Ralph

“…Extracellular vesicles (EVs) are actively shed into the circulation from both cancer and host cells. EVs are emerging as one of the diagnostic frontrunners for…”
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In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy by Arlauckas, Sean P, Garris, Christopher S, Kohler, Rainer H, Kitaoka, Maya, Cuccarese, Michael F, Yang, Katherine S, Miller, Miles A, Carlson, Jonathan C, Freeman, Gordon J, Anthony, Robert M, Weissleder, Ralph, Pittet, Mikael J

“…Monoclonal antibodies (mAbs) targeting the immune checkpoint anti-programmed cell death protein 1 (aPD-1) have demonstrated impressive benefits for the…”
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Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy by Yang, Katherine S, Im, Hyungsoon, Hong, Seonki, Pergolini, Ilaria, Del Castillo, Andres Fernandez, Wang, Rui, Clardy, Susan, Huang, Chen-Han, Pille, Craig, Ferrone, Soldano, Yang, Robert, Castro, Cesar M, Lee, Hakho, Del Castillo, Carlos Fernandez, Weissleder, Ralph

“…Pancreatic ductal adenocarcinoma (PDAC) is usually detected late in the disease process. Clinical workup through imaging and tissue biopsies is often complex…”
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Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact by Spitzberg, Joshua D., Ferguson, Scott, Yang, Katherine S., Peterson, Hannah M., Carlson, Jonathan C. T., Weissleder, Ralph

“…Exosomes and extracellular vesicles (EV) are increasingly being explored as circulating biomarkers, but their heterogenous composition will likely mandate the…”
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Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle by Miller, Miles A, Gadde, Suresh, Pfirschke, Christina, Engblom, Camilla, Sprachman, Melissa M, Kohler, Rainer H, Yang, Katherine S, Laughney, Ashley M, Wojtkiewicz, Gregory, Kamaly, Nazila, Bhonagiri, Sushma, Pittet, Mikael J, Farokhzad, Omid C, Weissleder, Ralph

“…Therapeutic nanoparticles (TNPs) have shown heterogeneous responses in human clinical trials, raising questions of whether imaging should be used to identify…”
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Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug by Miller, Miles A., Zheng, Yao-Rong, Gadde, Suresh, Pfirschke, Christina, Zope, Harshal, Engblom, Camilla, Kohler, Rainer H., Iwamoto, Yoshiko, Yang, Katherine S., Askevold, Bjorn, Kolishetti, Nagesh, Pittet, Mikael, Lippard, Stephen J., Farokhzad, Omid C., Weissleder, Ralph

“…Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in…”
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Extracellular Vesicle Analysis Allows for Identification of Invasive IPMN by Yang, Katherine S., Ciprani, Debora, O’Shea, Aileen, Liss, Andrew S., Yang, Robert, Fletcher-Mercaldo, Sarah, Mino-Kenudson, Mari, Fernández-del Castillo, Carlos, Weissleder, Ralph

“…Advances in cross-sectional imaging have resulted in increased detection of intraductal papillary mucinous neoplasms (IPMNs), and their management remains…”
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Characterization of single microvesicles in plasma from glioblastoma patients by Fraser, Kyle, Jo, Ala, Giedt, Jimmy, Vinegoni, Claudio, Yang, Katherine S, Peruzzi, Pierepaolo, Chiocca, E Antonio, Breakefield, Xandra O, Lee, Hakho, Weissleder, Ralph

“…Extracellular vesicles (EV) are shed by tumor cells but little is known about their individual molecular phenotypes and heterogeneity. While exosomes have…”
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Bioorthogonal Imaging of Aurora Kinase A in Live Cells by Yang, Katherine S., Budin, Ghyslain, Reiner, Thomas, Vinegoni, Claudio, Weissleder, Ralph

“…In living color: Aurora kinase A (AKA) was imaged in live cells using a bioorthogonal two‐step reaction with a small molecule AKA inhibitor (see scheme) and a…”
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Extracellular vesicle analysis of plasma allows differential diagnosis of atypical pancreatic serous cystadenoma by Yang, Katherine S., O’Shea, Aileen, Zelga, Piotr, Liss, Andrew S., Del Castillo, Carlos Fernandez, Weissleder, Ralph

“…Increased use of cross-sectional imaging has resulted in frequent detection of incidental cystic pancreatic lesions. Serous cystadenomas (SCAs) are benign…”
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Red Si-rhodamine drug conjugates enable imaging in GFP cells by Kim, Eunha, Yang, Katherine S, Giedt, Randy J, Weissleder, Ralph

“…Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR…”
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Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells by Yang, Katherine S., Budin, Ghyslain, Tassa, Carlos, Kister, Olivier, Weissleder, Ralph

“…A proteomics method to pull down secondary drug targets from live cells is described. The drug of interest is modified with trans‐cyclooctene (TCO) and…”
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Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression by Kim, Eunha, Yang, Katherine S, Kohler, Rainer H, Dubach, John M, Mikula, Hannes, Weissleder, Ralph

“…Bruton’s tyrosine kinase (Btk) is intricately involved in anti-apoptotic signaling pathways in cancer and in regulating innate immune response. A number of Btk…”
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Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification by Budin, Ghyslain, Yang, Katherine S., Reiner, Thomas, Weissleder, Ralph

“…Click inside: A nuclear protein target, polo‐like kinase 1 (PLK1) was imaged using a biocompatible bioorthogonal ligation between a specific drug and a…”
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Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response by Giedt, Randy J., Fumene Feruglio, Paolo, Pathania, Divya, Yang, Katherine S., Kilcoyne, Aoife, Vinegoni, Claudio, Mitchison, Timothy J., Weissleder, Ralph

“…Mitochondria, which are essential organelles in resting and replicating cells, can vary in number, mass and shape. Past research has primarily focused on…”
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Magnetic Silica‐Coated Fluorescent Microspheres (MagSiGlow) for Simultaneous Detection of Tumor‐Associated Proteins by Halabi, Elias A., Gessner, Isabel, Yang, Katherine S., Kim, Jae‐Jun, Jana, Rupsa, Peterson, Hannah M., Spitzberg, Joshua D., Weissleder, Ralph

“…Multiplexed bead assays for solution‐phase biosensing often encounter cross‐over reactions during signal amplification steps, leading to unwanted false…”
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Single cell resolution in vivo imaging of DNA damage following PARP inhibition by Yang, Katherine S., Kohler, Rainer H., Landon, Matthieu, Giedt, Randy, Weissleder, Ralph

“…Targeting DNA repair pathways is a powerful strategy to treat cancers. To gauge efficacy in vivo , typical response markers include late stage effects such as…”
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Single-EV analysis (sEVA) of mutated proteins allows detection of stage 1 pancreatic cancer by Ferguson, Scott, Yang, Katherine S, Zelga, Piotr, Liss, Andrew S, Carlson, Jonathan C T, Del Castillo, Carlos Fernandez, Weissleder, Ralph

“…Tumor cell-derived extracellular vesicles (EVs) are being explored as circulating biomarkers, but it is unclear whether bulk measurements will allow early…”
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The Impact of Human Lipoaspirate and Adipose Tissue-Derived Stem Cells Contact Culture on Breast Cancer Cells: Implications in Breast Reconstruction by Ejaz, Asim, Yang, Katherine S, Venkatesh, Kaushik P, Chinnapaka, Somaiah, Kokai, Lauren E, Rubin, J Peter

“…Autologous fat transfer in the form of lipoaspirates for the reconstruction of the breast after breast cancer surgery is a commonly used procedure in plastic…”
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