Search Results - "Katherine Lawler"

Applications of artificial intelligence to aid early detection of dementia: A scoping review on current capabilities and future directions by Li, Renjie, Wang, Xinyi, Lawler, Katherine, Garg, Saurabh, Bai, Quan, Alty, Jane

“…[Display omitted] •With aging populations, we urgently need cost-effective digital biomarkers to detect dementia in the earliest stages.•Current clinical…”
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MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis by LaPierre, Mary P., Lawler, Katherine, Godbersen, Svenja, Farooqi, I. Sadaf, Stoffel, Markus

“…MicroRNAs (miRNAs) modulate physiological responses by repressing the expression of gene networks. We found that global deletion of microRNA-7 (miR-7), the…”
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Current evidence on the association of tongue strength with cognitive decline in older adults and the known risk factors of frailty, sarcopenia and nutritional health: a scoping review protocol by Yitbarek, Getachew Yideg, Alty, Jane, Lawler, Katherine, Goldberg, Lynette Ruth

“…IntroductionEvidence suggests that the pathology underlying cognitive decline leading to dementia begins 15–20 years before cognitive symptoms emerge. Thus,…”
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Changing the focus: Facilitating engagement in physical activity for people living with mild dementia in a local community-Protocol for a pre-post mixed methods feasibility study by Lee, Den-Ching A, Callisaya, Michele, Meyer, Claudia, Taylor, Morag E, Lawler, Katherine, Levinger, Pazit, Hunter, Susan, Mackey, Dawn, Burton, Elissa, Brusco, Natasha, Haines, Terry P, Ekegren, Christina, Crabtree, Amelia, Licciardi, Lisa, Hill, Keith D

“…This study aims to address and improve the low physical activity levels among people with mild dementia by implementing a novel shared decision-making and…”
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MicroRNA‐196a promotes an oncogenic effect in head and neck cancer cells by suppressing annexin A1 and enhancing radioresistance by Suh, Yae‐Eun, Raulf, Nina, Gäken, Joop, Lawler, Katherine, Urbano, Teresa Guerrero, Bullenkamp, Jessica, Gobeil, Stéphane, Huot, Jacques, Odell, Eddy, Tavassoli, Mahvash

“…Radiotherapy is a major treatment modality for head and neck squamous cell carcinoma (HNSCC). Up to 50% of patients with locally advanced disease relapse after…”
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Leptin-Mediated Changes in the Human Metabolome by Lawler, Katherine, Huang-Doran, Isabel, Sonoyama, Takuhiro, Collet, Tinh-Hai, Keogh, Julia M, Henning, Elana, O’Rahilly, Stephen, Bottolo, Leonardo, Farooqi, I Sadaf

“…Abstract Context While severe obesity due to congenital leptin deficiency is rare, studies in patients before and after treatment with leptin can provide…”
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ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation by Monypenny, James, Milewicz, Hanna, Flores-Borja, Fabian, Weitsman, Gregory, Cheung, Anthony, Chowdhury, Ruhe, Burgoyne, Thomas, Arulappu, Appitha, Lawler, Katherine, Barber, Paul R., Vicencio, Jose M., Keppler, Melanie, Wulaningsih, Wahyu, Davidson, Sean M., Fraternali, Franca, Woodman, Natalie, Turmaine, Mark, Gillett, Cheryl, Franz, Dafne, Quezada, Sergio A., Futter, Clare E., Von Kriegsheim, Alex, Kolch, Walter, Vojnovic, Borivoj, Carlton, Jeremy G., Ng, Tony

“…The immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA…”
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A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome by Bochukova, Elena G., Lawler, Katherine, Croizier, Sophie, Keogh, Julia M., Patel, Nisha, Strohbehn, Garth, Lo, Kitty K., Humphrey, Jack, Hokken-Koelega, Anita, Damen, Layla, Donze, Stephany, Bouret, Sebastien G., Plagnol, Vincent, Farooqi, I. Sadaf

“…Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We…”
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Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer by Evans, Rachel, Flores-Borja, Fabian, Nassiri, Sina, Miranda, Elena, Lawler, Katherine, Grigoriadis, Anita, Monypenny, James, Gillet, Cheryl, Owen, Julie, Gordon, Peter, Male, Victoria, Cheung, Anthony, Noor, Farzana, Barber, Paul, Marlow, Rebecca, Francesch-Domenech, Erika, Fruhwirth, Gilbert, Squadrito, Mario, Vojnovic, Borivoj, Tutt, Andrew, Festy, Frederic, De Palma, Michele, Ng, Tony

“…Lymphatic vasculature is crucial for metastasis in triple-negative breast cancer (TNBC); however, cellular and molecular drivers controlling lymphovascular…”
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Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila by Agrawal, Neha, Lawler, Katherine, Davidson, Catherine M, Keogh, Julia M, Legg, Robert, Barroso, Inês, Farooqi, I Sadaf, Brand, Andrea H

“…The discovery of human obesity-associated genes can reveal new mechanisms to target for weight loss therapy. Genetic studies of obese individuals and the…”
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A rare human variant that disrupts GPR10 signalling causes weight gain in mice by Talbot, Fleur, Feetham, Claire H., Mokrosiński, Jacek, Lawler, Katherine, Keogh, Julia M., Henning, Elana, Mendes de Oliveira, Edson, Ayinampudi, Vikram, Saeed, Sadia, Bonnefond, Amélie, Arslan, Mohammed, Yeo, Giles S. H., Froguel, Philippe, Bechtold, David A., Adamson, Antony, Humphreys, Neil, Barroso, Inês, Luckman, Simon M., Farooqi, I. Sadaf

“…Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with…”
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Mobile Telephone Short Message Service Reminders Can Reduce Nonattendance in Physical Therapy Outpatient Clinics: A Randomized Controlled Trial by Taylor, Nicholas F., PhD, Bottrell, Judy, BPhty, Lawler, Katherine, BPhty, Benjamin, Deenika, MPhty

“…Abstract Taylor NF, Bottrell J, Lawler K, Benjamin D. Mobile telephone short message service reminders can reduce nonattendance in physical therapy outpatient…”
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Outcomes After Caregiver-Provided Speech and Language or Other Allied Health Therapy: A Systematic Review by Lawler, Katherine, BPhys, Taylor, Nicholas F., PhD, Shields, Nora, PhD

“…Abstract Objective To investigate whether allied health therapy provided by caregivers improves patient outcomes. Data Sources Electronic databases MEDLINE,…”
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Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum by Alty, Jane, Goldberg, Lynette R, Roccati, Eddy, Lawler, Katherine, Bai, Quan, Huang, Guan, Bindoff, Aidan D, Li, Renjie, Wang, Xinyi, St George, Rebecca J, Rudd, Kaylee, Bartlett, Larissa, Collins, Jessica M, Aiyede, Mimieveshiofuo, Fernando, Nadeeshani, Bhagwat, Anju, Giffard, Julia, Salmon, Katharine, McDonald, Scott, King, Anna E, Vickers, James C

“…Dementia prevalence is predicted to triple to 152 million globally by 2050. Alzheimer's disease (AD) constitutes 70% of cases. There is an urgent need to…”
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The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer’s disease and estimate 5-year risks of cognitive decline and dementia by Alty, Jane, Bai, Quan, Li, Renjie, Lawler, Katherine, St George, Rebecca J, Hill, Edward, Bindoff, Aidan, Garg, Saurabh, Wang, Xinyi, Huang, Guan, Zhang, Kaining, Rudd, Kaylee D, Bartlett, Larissa, Goldberg, Lynette R, Collins, Jessica M, Hinder, Mark R, Naismith, Sharon L, Hogg, David C, King, Anna E, Vickers, James C

“…Abstract Background The worldwide prevalence of dementia is rapidly rising. Alzheimer’s disease (AD), accounts for 70% of cases and has a 10–20-year…”
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Contributions of transcription and mRNA decay to gene expression dynamics of fission yeast in response to oxidative stress by Marguerat, Samuel, Lawler, Katherine, Brazma, Alvis, Bähler, Jürg

“…The cooperation of transcriptional and post-transcriptional levels of control to shape gene regulation is only partially understood. Here we show that a…”
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Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity by Cimino, Irene, Rimmington, Debra, Tung, Y. C. Loraine, Lawler, Katherine, Larraufie, Pierre, Kay, Richard G., Virtue, Samuel, Lam, Brian Y. H., Fagnocchi, Luca, Ma, Marcella K. L., Saudek, Vladimir, Zvetkova, Ilona, Vidal-Puig, Antonio, Yeo, Giles S. H., Farooqi, I. Sadaf, Pospisilik, J. Andrew, Gribble, Fiona M., Reimann, Frank, O’Rahilly, Stephen, Coll, Anthony P.

“…Neuronatin ( Nnat ) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28…”
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Brief webcam test of hand movements predicts episodic memory, executive function, and working memory in a community sample of cognitively asymptomatic older adults by Li, Renjie, Wang, Xinyi, Lawler, Katherine, Garg, Saurabh, St George, Rebecca J., Bindoff, Aidan D., Bartlett, Larissa, Roccati, Eddy, King, Anna E., Vickers, James C., Bai, Quan, Alty, Jane

“…INTRODUCTION Low‐cost simple tests for preclinical Alzheimer's disease are a research priority. We evaluated whether remote unsupervised webcam recordings of…”
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Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study by Lawler, Katherine, Papouli, Efterpi, Naceur-Lombardelli, Cristina, Mera, Anca, Ougham, Kayleigh, Tutt, Andrew, Kimbung, Siker, Hedenfalk, Ingrid, Zhan, Jun, Zhang, Hongquan, Buus, Richard, Dowsett, Mitch, Ng, Tony, Pinder, Sarah E, Parker, Peter, Holmberg, Lars, Gillett, Cheryl E, Grigoriadis, Anita, Purushotham, Arnie

“…Metastases from primary breast cancers can involve single or multiple organs at metastatic disease diagnosis. Molecular risk factors for particular patterns of…”
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DART: Denoising Algorithm based on Relevance network Topology improves molecular pathway activity inference by Jiao, Yan, Lawler, Katherine, Patel, Gargi S, Purushotham, Arnie, Jones, Annette F, Grigoriadis, Anita, Tutt, Andrew, Ng, Tony, Teschendorff, Andrew E

“…Inferring molecular pathway activity is an important step towards reducing the complexity of genomic data, understanding the heterogeneity in clinical outcome,…”
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