Search Results - "Kathe, Scott D"

Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases by Nelson, Shane R, Dunn, Andrew R, Kathe, Scott D, Warshaw, David M, Wallace, Susan S

“…DNA glycosylases are enzymes that perform the initial steps of base excision repair, the principal repair mechanism that identifies and removes endogenous…”
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Single-Stranded Breaks in DNA but Not Oxidative DNA Base Damages Block Transcriptional Elongation by RNA Polymerase II in HeLa Cell Nuclear Extracts by Kathe, Scott D, Shen, Guang-Ping, Wallace, Susan S

“…Transcription and repair of many DNA helix-distorting lesions such as cyclobutane pyrimidine dimers have been shown to be coupled in cells across phyla from…”
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Detection of OG:A Lesion Mispairs by MutY Relies on a Single His Residue and the 2‑Amino Group of 8‑Oxoguanine by Lee, Andrea J, Majumdar, Chandrima, Kathe, Scott D, Van Ostrand, Robert P, Vickery, Holly R, Averill, April M, Nelson, Shane R, Manlove, Amelia H, McCord, Morgan A, David, Sheila S

“…MutY glycosylase excises adenines misincorporated opposite the oxidatively damaged lesion, 8-oxo-7,8-dihydroguanine (OG), to initiate base excision repair and…”
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Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability by Marsden, Carolyn G., Das, Lipsa, Nottoli, Timothy P., Kathe, Scott D., Doublié, Sylvie, Wallace, Susan S., Sweasy, Joann B.

“…Oxidative DNA damage as a result of normal cellular metabolism, inflammation, or exposure to exogenous DNA damaging agents if left unrepaired, can result in…”
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Single molecule glycosylase studies with engineered 8-oxoguanine DNA damage sites show functional defects of a MUTYH polyposis variant by Nelson, Shane R, Kathe, Scott D, Hilzinger, Thomas S, Averill, April M, Warshaw, David M, Wallace, Susan S, Lee, Andrea J

“…Abstract Proper repair of oxidatively damaged DNA bases is essential to maintain genome stability. 8-Oxoguanine (7,8-dihydro-8-oxoguanine, 8-oxoG) is a…”
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Bacterial origin of a chloroplast intron: conserved self-splicing group I introns in cyanobacteria by Xu, M.Q. (State University of New York, Albany, NY), Kathe, S.D, Goodrich-Blair, H, Nierzwicki-Bauer, S.A, Shub, D.A

“…A self-splicing group I intron has been found in the gene for a leucine transfer RNA in two species of Anabaena, a filamentous nitrogen-fixing cyanobacterium…”
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Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases by Kathe, Scott D., Barrantes-Reynolds, Ramiro, Jaruga, Pawel, Newton, Michael R., Burrows, Cynthia J., Bandaru, Viswanath, Dizdaroglu, Miral, Bond, Jeffrey P., Wallace, Susan S.

“…Formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) share an overall common three-dimensional structure and primary amino acid sequence in…”
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The enigma of endonuclease VIII by Wallace, Susan S, Bandaru, Viswanath, Kathe, Scott D, Bond, Jeffrey P

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Origin and evolution of group I introns in cyanobacterial tRNA genes by Paquin, B, Kathe, S D, Nierzwicki-Bauer, S A, Shub, D A

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Detection of OG:A lesion mispairs by MutY relies on interactions of a single His residue with the 2-amino group of 8-oxoguanine by Lee, Andrea J., Majumdar, Chandrima, Kathe, Scott D., Van Ostrand, Robert P., Vickery, Holly R., Averill, April M., Nelson, Shane R., Manlove, Amelia H., McCord, Morgan A., David, Sheila S.

“…MutY glycosylase excises adenines misincorporated opposite the oxidatively damaged lesion, 8-oxo-7,8-dihydroguanine (OG), to initiate base excision repair and…”
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Direct Observation of MUTYH and the Cancer-Associated Y150C Variant Binding to OG: A Mismatches at the Single Molecule Level by Nelson, Shane R., Lee, Andrea J., Kathe, Scott D., Hilzinger, Thomas S., Averill, April M., Wallace, Susan S., Warshaw, David M.

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Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases by Nelson, Shane R., Dunn, Andrew R., Kathe, Scott D., Warshaw, David, Wallace, Susan S.

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Single-stranded breaks in DNA but not oxidative DNA base damages block transcriptional elongation by RNA polymerase II in HeLa cell nuclear extracts. Vol. 279 (2004) 18511-18520 by Kathe, Scott D., Shen, Guang-Ping, Wallace, Susan S.

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