Search Results - "Katharina Höhn"
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EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites
Published in PLoS biology (30-09-2019)“…Intracellular malaria parasites grow in a vacuole delimited by the parasitophorous vacuolar membrane (PVM). This membrane fulfils critical roles for survival…”
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2
GroEL is an immunodominant surface-exposed antigen of Rickettsia typhi
Published in PloS one (10-06-2021)“…Rickettsioses are neglected and emerging potentially fatal febrile diseases that are caused by obligate intracellular bacteria, rickettsiae. Rickettsia (R.)…”
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3
Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions
Published in Scientific reports (11-03-2020)“…Characterizing the adhesive dynamics of Plasmodium falciparum infected erythrocytes (IEs) to different endothelial cell receptors (ECRs) in flow is a big…”
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High-pressure freezing for scanning transmission electron tomography analysis of cellular organelles
Published in Methods in molecular biology (Clifton, N.J.) (2013)“…Using an electron microscope's scanning transmission mode (STEM) for collection of tomographic datasets is advantageous compared to bright field transmission…”
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Stringent Selection of Knobby Plasmodium falciparum -Infected Erythrocytes during Cytoadhesion at Febrile Temperature
Published in Microorganisms (Basel) (25-01-2020)“…Changes in the erythrocyte membrane induced by invasion allow cytoadhesion of infected erythrocytes (IEs) to the host endothelium, which can lead to severe…”
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A Telomeric Cluster of Antimony Resistance Genes on Chromosome 34 of Leishmania infantum
Published in Antimicrobial agents and chemotherapy (01-09-2016)“…The mechanisms underlying the drug resistance of Leishmania spp. are manifold and not completely identified. Apart from the highly conserved multidrug…”
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Plasmodium falciparum infection reshapes the human microRNA profiles of red blood cells and their extracellular vesicles
Published in iScience (21-07-2023)“…Plasmodium falciparum, a human malaria parasite, develops in red blood cells (RBCs), which represent approximately 70% of all human blood cells. Additionally,…”
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8
Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network
Published in Cellular microbiology (01-12-2017)“…Summary Reovirus replication occurs in the cytoplasm of the host cell, in virally induced mini‐organelles called virus factories. On the basis of the serotype…”
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9
PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites
Published in Cell host & microbe (09-01-2019)“…During development in human erythrocytes, the malaria parasite Plasmodium falciparum internalizes a large part of the cellular content of the host cell. The…”
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10
Role of Rabenosyn-5 and Rab5b in host cell cytosol uptake reveals conservation of endosomal transport in malaria parasites
Published in PLoS biology (31-05-2024)“…Vesicular trafficking, including secretion and endocytosis, plays fundamental roles in the unique biology of Plasmodium falciparum blood-stage parasites…”
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11
FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model
Published in Cardiovascular research (01-09-2011)“…The transcription factor FoxO3 contributes to anti-hypertrophic signalling in the heart presumably by regulating autophagic-lysosomal and ubiquitin-proteasomal…”
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12
FIB/SEM tomography with TEM-like resolution for 3D imaging of high-pressure frozen cells
Published in Histochemistry and cell biology (01-10-2012)“…Focused ion beam/scanning electron microscopy (FIB/SEM) tomography is a novel powerful approach for three-dimensional (3D) imaging of biological samples…”
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13
Distinct brain and lung endothelial miRNA/mRNA profiles after exposure to Plasmodium falciparum-infected red blood cells
Published in iScience (15-11-2024)“…MicroRNAs (miRNAs) control 60% of genes expressed in the human body, but their role in malaria pathogenesis is incompletely understood. Here, we demonstrate…”
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14
Preparation of cryofixed cells for improved 3D ultrastructure with scanning transmission electron tomography
Published in Histochemistry and cell biology (2011)“…Scanning transmission electron tomography offers enhanced contrast compared to regular transmission electron microscopy, and thicker samples, up to 1 μm or…”
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15
GroEL is an immunodominant surface-exposed antigen of Rickettsia typhi
Published in PloS one (01-01-2021)“…Rickettsioses are neglected and emerging potentially fatal febrile diseases that are caused by obligate intracellular bacteria, rickettsiae. Rickettsia (R.)…”
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16
IGF‐1 drives chromogranin A secretion via activation of Arf1 in human neuroendocrine tumour cells
Published in Journal of cellular and molecular medicine (01-05-2015)“…Hypersecretion is the major symptom of functional neuroendocrine tumours. The mechanisms that contribute to this excessive secretion of hormones are still…”
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17
Novel electron tomographic methods to study the morphology of keratin filament networks
Published in Microscopy and microanalysis (01-08-2010)“…The three-dimensional (3D) keratin filament network of pancreatic carcinoma cells was investigated with different electron microscopical approaches. Semithin…”
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18
Three-dimensional imaging of adherent cells using FIB/SEM and STEM
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2014)“…In this chapter we describe three different approaches for three-dimensional imaging of electron microscopic samples: serial sectioning transmission electron…”
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