Prevalence and Risk Factors for Hepatitis C Virus, Hepatitis B Virus, and Human Immunodeficiency Virus in Transfused Children in Kinshasa

Objective To determine seroprevalence of hepatitis C virus (HCV), human immunodeficiency virus (HIV), and hepatitis B virus (HBV) and associated factors among transfused children. Methods A multicenter cross-sectional study of transfused children aged between 18 mo and 13 y old was conducted in 4 ho...

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Bibliographic Details
Published in:	Indian journal of pediatrics Vol. 80; no. 8; pp. 659 - 662
Main Authors:	Katabuka, M., Mafuta, M. E., Ngoma, A. M., Beya, P. Mutombo, Yuma, S., Aketi, L., Kayembe, K. P., Gini, J. R.
Format:	Journal Article
Language:	English
Published:	India Springer India 01-08-2013 Springer
Subjects:	Adolescent Biological and medical sciences Blood Transfusion Child Child, Preschool Cross-Sectional Studies Female General aspects Gynecology Hepatitis B - epidemiology Hepatitis C - epidemiology HIV Infections - epidemiology Human viral diseases Humans Infant Infectious diseases Male Medical sciences Medicine Medicine & Public Health Original Article Pediatrics Prevalence Risk Factors Seroepidemiologic Studies Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral hepatitis Transfusion Human immunodeficiency virus Hepatitis B virus Children Hepatitis C virus Pediatrics Prevalence Orthohepadnavirus Hepatic disease Epidemiology Viral hepatitis B Hepadnaviridae Tropical medicine Child Viral hepatitis C Human Immunopathology Retroviridae AIDS Immune deficiency Lentivirus Infection Virus Viral disease Risk factor Digestive diseases Flaviviridae Hepacivirus
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Summary:	Objective To determine seroprevalence of hepatitis C virus (HCV), human immunodeficiency virus (HIV), and hepatitis B virus (HBV) and associated factors among transfused children. Methods A multicenter cross-sectional study of transfused children aged between 18 mo and 13 y old was conducted in 4 hospitals in Kinshasa. Blood samples were collected for the detection of Hepatitis B surface antigen (HBsAg) and antibodies to HCV, HIV 1and 2. Results A total of 177 (47.7 %) boys and 194 (52.3 %) girls participated in the study. The median age was 59.5 mo (Interquartile range IQR = 60.6). The prevalence rates of HCV, HBV, and HIV infection were 13.5 %, 1.6 %, and 1.3 %, respectively. Frequency of transfusion events were significantly associated with HCV ( p < 0.001) and HIV ( p < 0.05) infections. Conclusions HCV infection was by far more frequently identified than HBV and HIV infections among Congolese transfused children. Frequency of transfusion events was the only significant risk factor associated with HCV and HIV infections but not for HBV.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0019-5456 0973-7693
DOI:	10.1007/s12098-012-0899-1