Search Results - "Kasule, Jingo"
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HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy
Published in Nature communications (02-07-2024)“…The primary obstacle to curing HIV-1 is a reservoir of CD4+ cells that contain stably integrated provirus. Previous studies characterizing the proviral…”
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Psychosocial and Economic Risks of Institutional Quarantine in a Low-Resource Setting: Experiences of Affected Persons during the COVID-19 Pandemic in Uganda
Published in COVID (01-09-2023)“…Institutional quarantine was one of the key public health measures used to control the spread of the Corona Virus Disease 2019 (COVID-19). Institutional…”
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The Incidence Patterns Model to Estimate the Distribution of New HIV Infections in Sub-Saharan Africa: Development and Validation of a Mathematical Model
Published in PLoS medicine (13-09-2016)“…Programmatic planning in HIV requires estimates of the distribution of new HIV infections according to identifiable characteristics of individuals. In…”
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OP 3.7 – 00099 Cohort-specific Adaptation of the Intact Proviral DNA Assay (IPDA) to HIV-1 subtypes A1, D, and recombinants
Published in Journal of Virus Eradication (01-12-2022)Get full text
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Quantitation of the latent HIV-1 reservoir from the sequence diversity in viral outgrowth assays
Published in Retrovirology (05-07-2018)“…The ability of HIV-1 to integrate into the genomes of quiescent host immune cells, establishing a long-lived latent viral reservoir (LVR), is the primary…”
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Rates of switching to second-line antiretroviral therapy and impact of delayed switching on immunologic, virologic, and mortality outcomes among HIV-infected adults with virologic failure in Rakai, Uganda
Published in BMC infectious diseases (22-08-2017)“…Switch from first to second-line ART is recommended by WHO for patients with virologic failure. Delays in switching may contribute to accumulated drug…”
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Reduced Frequency of Cells Latently Infected With Replication-Competent Human Immunodeficiency Virus-1 in Virally Suppressed Individuals Living in Rakai, Uganda
Published in Clinical infectious diseases (15-10-2017)“…Background. Human immunodeficiency virus type 1 (HIV-1) persists in latently infected resting CD4+ T cells (rCD4 cells), posing a major barrier to curing HIV-1…”
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Reduced HIV-1 latent reservoir outgrowth and distinct immune correlates among women in Rakai, Uganda
Published in JCI insight (23-07-2020)“…HIV-1 infection remains incurable owing to the persistence of a viral reservoir that harbors integrated provirus within host cellular DNA. Increasing evidence…”
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Sulfamethoxazole Levels in HIV-Exposed Uninfected Ugandan Children
Published in The American journal of tropical medicine and hygiene (01-01-2018)“…Trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis in HIV-uninfected, exposed (HUE) children variably reduces clinical malaria burden despite antifolate…”
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336. Developing a Protein Signature of Early Latent Tuberculosis Infection
Published in Open forum infectious diseases (15-12-2022)Get full text
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