The Metabolic Syndrome and Male Infertility

The Metabolic Syndrome and Male Infertility

Metabolic syndrome (MetS) is highly prevalent, affecting more than 47 million US residents. This condition is also multifaceted, potentially leading to significant disturbance of numerous physiologic processes. This review article evaluates the literature regarding metabolic syndrome and male reprod...

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Bibliographic Details
Published in:Journal of andrology Vol. 29; no. 3; pp. 251 - 259
Main Authors: Kasturi, Sanjay S, Tannir, Justin, Brannigan, Robert E
Format: Journal Article
Language:English
Published: Oxford, UK Am Soc Andrology 01-05-2008
Blackwell Publishing Ltd
American Society of Andrology
Subjects:
Biological and medical sciences
Birth control
Diabetes Mellitus, Type 2 - complications
Fundamental and applied biological sciences. Psychology
Gynecology. Andrology. Obstetrics
Humans
Infertility, Male - etiology
Male
Male genital diseases
Mammalian male genital system
Medical sciences
Metabolic diseases
Metabolic Syndrome - complications
Miscellaneous
Obesity - complications
Other metabolic disorders
Sterility. Assisted procreation
Vertebrates: reproduction
Endocrinopathy
Reproduction
Metabolic diseases
Cardiovascular disease
Male sterility
Metabolic syndrome
Male genital diseases
Male genital system
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Summary:Metabolic syndrome (MetS) is highly prevalent, affecting more than 47 million US residents. This condition is also multifaceted, potentially leading to significant disturbance of numerous physiologic processes. This review article evaluates the literature regarding metabolic syndrome and male reproductive health. Links between obesity, dyslipidemia, hypertension, and insulin resistance are each examined with regard to their associated detrimental effects on male fertility. At the end of this manuscript, we propose a new MetS/male infertility paradigm. Additional studies specifically addressing the components of MetS and their impact on male reproduction will enhance our understanding of the underlying pathophysiology. These studies may also help clarify the role for therapeutic intervention.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0196-3635
1939-4640
DOI:10.2164/jandrol.107.003731