Search Results - "Kastenmüller, Gabi"

Plasma metabolites to profile pathways in noncommunicable disease multimorbidity by Pietzner, Maik, Stewart, Isobel D., Raffler, Johannes, Khaw, Kay-Tee, Michelotti, Gregory A., Kastenmüller, Gabi, Wareham, Nicholas J., Langenberg, Claudia

“…Multimorbidity, the simultaneous presence of multiple chronic conditions, is an increasing global health problem and research into its determinants is of high…”
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Multi-omics integration in biomedical research – A metabolomics-centric review by Wörheide, Maria A., Krumsiek, Jan, Kastenmüller, Gabi, Arnold, Matthias

“…Recent advances in high-throughput technologies have enabled the profiling of multiple layers of a biological system, including DNA sequence data (genomics),…”
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Connecting genetic risk to disease end points through the human blood plasma proteome by Suhre, Karsten, Arnold, Matthias, Bhagwat, Aditya Mukund, Cotton, Richard J., Engelke, Rudolf, Raffler, Johannes, Sarwath, Hina, Thareja, Gaurav, Wahl, Annika, DeLisle, Robert Kirk, Gold, Larry, Pezer, Marija, Lauc, Gordan, El-Din Selim, Mohammed A., Mook-Kanamori, Dennis O., Al-Dous, Eman K., Mohamoud, Yasmin A., Malek, Joel, Strauch, Konstantin, Grallert, Harald, Peters, Annette, Kastenmüller, Gabi, Gieger, Christian, Graumann, Johannes

“…Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in metabolite and protein levels, provide functional evidence to map disease…”
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SNiPA: an interactive, genetic variant-centered annotation browser by Arnold, Matthias, Raffler, Johannes, Pfeufer, Arne, Suhre, Karsten, Kastenmüller, Gabi

“…Linking genes and functional information to genetic variants identified by association studies remains difficult. Resources containing extensive genomic…”
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Integration of ‘omics’ data in aging research: from biomarkers to systems biology by Zierer, Jonas, Menni, Cristina, Kastenmüller, Gabi, Spector, Tim D.

“…Summary Age is the strongest risk factor for many diseases including neurodegenerative disorders, coronary heart disease, type 2 diabetes and cancer. Due to…”
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Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome by Arnold, Matthias, Nho, Kwangsik, Kueider-Paisley, Alexandra, Massaro, Tyler, Huynh, Kevin, Brauner, Barbara, MahmoudianDehkordi, Siamak, Louie, Gregory, Moseley, M. Arthur, Thompson, J. Will, John-Williams, Lisa St, Tenenbaum, Jessica D., Blach, Colette, Chang, Rui, Brinton, Roberta D., Baillie, Rebecca, Han, Xianlin, Trojanowski, John Q., Shaw, Leslie M., Martins, Ralph, Weiner, Michael W., Trushina, Eugenia, Toledo, Jon B., Meikle, Peter J., Bennett, David A., Krumsiek, Jan, Doraiswamy, P. Murali, Saykin, Andrew J., Kaddurah-Daouk, Rima, Kastenmüller, Gabi

“…Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors…”
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Genetic architecture of host proteins involved in SARS-CoV-2 infection by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Raffler, Johannes, Kerrison, Nicola D., Oerton, Erin, Auyeung, Victoria P. W., Luan, Jian’an, Finan, Chris, Casas, Juan P., Ostroff, Rachel, Williams, Steve A., Kastenmüller, Gabi, Ralser, Markus, Gamazon, Eric R., Wareham, Nicholas J., Hingorani, Aroon D., Langenberg, Claudia

“…Understanding the genetic architecture of host proteins interacting with SARS-CoV-2 or mediating the maladaptive host response to COVID-19 can help to identify…”
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The fecal metabolome as a functional readout of the gut microbiome by Zierer, Jonas, Jackson, Matthew A., Kastenmüller, Gabi, Mangino, Massimo, Long, Tao, Telenti, Amalio, Mohney, Robert P., Small, Kerrin S., Bell, Jordana T., Steves, Claire J., Valdes, Ana M., Spector, Tim D., Menni, Cristina

“…The human gut microbiome plays a key role in human health 1 , but 16S characterization lacks quantitative functional annotation 2 . The fecal metabolome…”
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Mapping the proteo-genomic convergence of human diseases by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Cortes, Adrian, Koprulu, Mine, Wörheide, Maria A, Oerton, Erin, Cook, James, Stewart, Isobel D, Kerrison, Nicola D, Luan, Jian'an, Raffler, Johannes, Arnold, Matthias, Arlt, Wiebke, O'Rahilly, Stephen, Kastenmüller, Gabi, Gamazon, Eric R, Hingorani, Aroon D, Scott, Robert A, Wareham, Nicholas J, Langenberg, Claudia

“…Characterization of the genetic regulation of proteins is essential for understanding disease etiology and developing therapies. We identified 10,674 genetic…”
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Comprehensive metabolic profiling of chronic low-grade inflammation among generally healthy individuals by Pietzner, Maik, Kaul, Anne, Henning, Ann-Kristin, Kastenmüller, Gabi, Artati, Anna, Lerch, Markus M, Adamski, Jerzy, Nauck, Matthias, Friedrich, Nele

“…Inflammation occurs as an immediate protective response of the immune system to a harmful stimulus, whether locally confined or systemic. In contrast, a…”
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Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach by MENNI, Cristina, FAUMAN, Eric, WEI YUAN, MILBURN, Mike, PALMER, Colin N. A, FRAYLING, Timothy M, TRIMMER, Jeff, BELL, Jordana T, GIEGER, Christian, MOHNEY, Rob P, BROSNAN, Mary Julia, SUHRE, Karsten, ERTE, Idil, SORANZO, Nicole, SPECTOR, Tim D, PERRY, John R. B, KASTENMÜLLER, Gabi, SHIN, So-Youn, PETERSEN, Ann-Kristin, HYDE, Craig, PSATHA, Maria, WARD, Kirsten J

“…Using a nontargeted metabolomics approach of 447 fasting plasma metabolites, we searched for novel molecular markers that arise before and after hyperglycemia…”
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Metabolomic and inflammatory signatures of symptom dimensions in major depression by Brydges, Christopher R., Bhattacharyya, Sudeepa, Dehkordi, Siamak Mahmoudian, Milaneschi, Yuri, Penninx, Brenda, Jansen, Rick, Kristal, Bruce S., Han, Xianlin, Arnold, Matthias, Kastenmüller, Gabi, Bekhbat, Mandakh, Mayberg, Helen S, Craighead, W. Edward, Rush, A John, Fiehn, Oliver, Dunlop, Boadie W, Kaddurah-Daouk, Rima

“…•Major depressive disorder (MDD) can be theorized as a series of symptom dimensions.•We examined metabolic associations of three MDD symptom…”
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Genetic diagnosis of Mendelian disorders via RNA sequencing by Kremer, Laura S., Bader, Daniel M., Mertes, Christian, Kopajtich, Robert, Pichler, Garwin, Iuso, Arcangela, Haack, Tobias B., Graf, Elisabeth, Schwarzmayr, Thomas, Terrile, Caterina, Koňaříková, Eliška, Repp, Birgit, Kastenmüller, Gabi, Adamski, Jerzy, Lichtner, Peter, Leonhardt, Christoph, Funalot, Benoit, Donati, Alice, Tiranti, Valeria, Lombes, Anne, Jardel, Claude, Gläser, Dieter, Taylor, Robert W., Ghezzi, Daniele, Mayr, Johannes A., Rötig, Agnes, Freisinger, Peter, Distelmaier, Felix, Strom, Tim M., Meitinger, Thomas, Gagneur, Julien, Prokisch, Holger

“…Across a variety of Mendelian disorders, ∼50–75% of patients do not receive a genetic diagnosis by exome sequencing indicating disease-causing variants in…”
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A genome-wide perspective of genetic variation in human metabolism by Suhre, Karsten, Illig, Thomas, Gieger, Christian, Zhai, Guangju, Römisch-Margl, Werner, Wang-Sattler, Rui, Prehn, Cornelia, Altmaier, Elisabeth, Kastenmüller, Gabi, Kato, Bernet S, Mewes, Hans-Werner, Meitinger, Thomas, de Angelis, Martin Hrabé, Kronenberg, Florian, Soranzo, Nicole, Wichmann, H-Erich, Spector, Tim D, Adamski, Jerzy

“…Serum metabolite concentrations provide a direct readout of biological processes in the human body, and they are associated with disorders such as…”
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An atlas of genetic influences on human blood metabolites by Shin, So-Youn, Fauman, Eric B, Petersen, Ann-Kristin, Krumsiek, Jan, Santos, Rita, Huang, Jie, Arnold, Matthias, Erte, Idil, Forgetta, Vincenzo, Yang, Tsun-Po, Walter, Klaudia, Menni, Cristina, Chen, Lu, Vasquez, Louella, Valdes, Ana M, Hyde, Craig L, Wang, Vicky, Ziemek, Daniel, Roberts, Phoebe, Xi, Li, Grundberg, Elin, Waldenberger, Melanie, Richards, J Brent, Mohney, Robert P, Milburn, Michael V, John, Sally L, Trimmer, Jeff, Theis, Fabian J, Overington, John P, Suhre, Karsten, Brosnan, M Julia, Gieger, Christian, Kastenmüller, Gabi, Spector, Tim D, Soranzo, Nicole

“…Nicole Soranzo, Tim Spector, Gabi Kastenmüller and colleagues report a large-scale analysis of genetic variants influencing human blood metabolite levels. They…”
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A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals by Deelen, Joris, Kettunen, Johannes, Fischer, Krista, van der Spek, Ashley, Trompet, Stella, Kastenmüller, Gabi, Boyd, Andy, Zierer, Jonas, van den Akker, Erik B., Ala-Korpela, Mika, Amin, Najaf, Demirkan, Ayse, Ghanbari, Mohsen, van Heemst, Diana, Ikram, M. Arfan, van Klinken, Jan Bert, Mooijaart, Simon P., Peters, Annette, Salomaa, Veikko, Sattar, Naveed, Spector, Tim D., Tiemeier, Henning, Verhoeven, Aswin, Waldenberger, Melanie, Würtz, Peter, Davey Smith, George, Metspalu, Andres, Perola, Markus, Menni, Cristina, Geleijnse, Johanna M., Drenos, Fotios, Beekman, Marian, Jukema, J. Wouter, van Duijn, Cornelia M., Slagboom, P. Eline

“…Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics…”
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Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance by FERRANNINI, Ele, NATALI, Andrea, LYSSENKO, Valeriya, GROOP, Leif, GALL, Walter E, CAMASTRA, Stefania, NANNIPIERI, Monica, MARI, Andrea, ADAM, Klaus-Peter, MILBURN, Michael V, KASTENMÜLLER, Gabi, ADAMSKI, Jerzy, TUOMI, Tiinamaija

“…Metabolomic screening of fasting plasma from nondiabetic subjects identified α-hydroxybutyrate (α-HB) and linoleoyl-glycerophosphocholine (L-GPC) as joint…”
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Metabolite Concentration Changes in Humans After a Bout of Exercise: a Systematic Review of Exercise Metabolomics Studies by Schranner, Daniela, Kastenmüller, Gabi, Schönfelder, Martin, Römisch-Margl, Werner, Wackerhage, Henning

“…Background Exercise changes the concentrations of many metabolites, which are small molecules (< 1.5 kDa) metabolized by the reactions of human metabolism. In…”
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Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information by Krumsiek, Jan, Suhre, Karsten, Evans, Anne M, Mitchell, Matthew W, Mohney, Robert P, Milburn, Michael V, Wägele, Brigitte, Römisch-Margl, Werner, Illig, Thomas, Adamski, Jerzy, Gieger, Christian, Theis, Fabian J, Kastenmüller, Gabi

“…Recent genome-wide association studies (GWAS) with metabolomics data linked genetic variation in the human genome to differences in individual metabolite…”
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Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies by Do, Kieu Trinh, Wahl, Simone, Raffler, Johannes, Molnos, Sophie, Laimighofer, Michael, Adamski, Jerzy, Suhre, Karsten, Strauch, Konstantin, Peters, Annette, Gieger, Christian, Langenberg, Claudia, Stewart, Isobel D., Theis, Fabian J., Grallert, Harald, Kastenmüller, Gabi, Krumsiek, Jan

“…Background Untargeted mass spectrometry (MS)-based metabolomics data often contain missing values that reduce statistical power and can introduce bias in…”
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