Search Results - "Kastan, M"

The ATM-dependent DNA damage signaling pathway by Kitagawa, R, Kastan, M B

“…Many of the insights that we have gained into the mechanisms involved in cellular DNA damage response pathways have come from studies of human cancer…”
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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway by Kastan, Michael B, Lim, Dae-Sik, Kim, Seong-Tae, Xu, Bo, Maser, Richard S, Lin, Junyu, Petrini, John H.J

“…The rare diseases ataxia-telangiectasia (AT), caused by mutations in the ATM gene, and Nijmegen breakage syndrome (NBS), with mutations in the p95/nbs1 gene,…”
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Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53 by Canman, Christine E., Lim, Dae-Sik, Cimprich, Karlene A., Taya, Yoichi, Tamai, Katsuyuki, Sakaguchi, Kazuyasu, Appella, Ettore, Kastan, Michael B., Siliciano, Janet D.

“…The p53 tumor suppressor protein is activated and phosphorylated on serine-15 in response to various DNA damaging agents. The gene product mutated in ataxia…”
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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation by Baskaran, R, Wood, L. D, Whitaker, L. L, Canman, C. E, Morgan, S. E, Xu, Y, Barlow, C, Baltimore, D, Wynshaw-Boris, A, Kastan, M. B, Wang, J. Y. J

“…Ataxia telangiectasia (AT) is a rare human autosomal recessive disorder with pleiotropic phenotypes, including neuronal degeneration, immune dysfunction,…”
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Tumor-suppressor p53: implications for tumor development and prognosis by Kirsch, D G, Kastan, M B

“…The p53 protein plays a central role in modulating cellular responses to cytotoxic stresses by contributing to both cell-cycle arrest and programmed cell…”
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Cell Cycle Control and Cancer by Hartwell, Leland H., Kastan, Michael B.

“…Multiple genetic changes occur during the evolution of normal cells into cancer cells. This evolution is facilitated in cancer cells by loss of fidelity in the…”
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Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies by Sandlund, J.T., Hudson, M.M., Kennedy, W., Onciu, M., Kastan, M.B.

“…Children with ataxia–telangiectasia (A–T) and cancer have a poorer prognosis due in part to increased treatment‐related toxicity. We piloted a curative intent…”
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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation by Kastan, Michael B, Bakkenist, Christopher J

“…The ATM protein kinase, mutations of which are associated with the human disease ataxia-telangiectasia, mediates responses to ionizing radiation in mammalian…”
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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways by NELSON, W. G, KASTAN, M. B

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Initiating Cellular Stress Responses by Bakkenist, Christopher J, Kastan, Michael B

“…The phosphoinositide 3-kinase related kinases (PIKKs) mediate responses to diverse stresses, including DNA double-strand breaks (DSBs), abnormal replication…”
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Abeloff's clinical oncology by Niederhuber, John E, Armitage, James O, Doroshow, James H, Kastan, Michael B, Tepper, Joel E

“…This reference synthesises modern oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology,…”
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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation by Xu, B, Kim St, Kastan, M B

“…Cell cycle arrests in the G(1), S, and G(2) phases occur in mammalian cells after ionizing irradiation and appear to protect cells from permanent genetic…”
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Conversion of Bcl-2 to a bax-like death effector by caspases by CHENG, E. H.-Y, KIRSCH, D. G, CLEM, R. J, RAVI, R, KASTAN, M. B, BEDI, A, UENO, K, HARDWICK, J. M

“…Caspases are a family of cysteine proteases implicated in the biochemical and morphological changes that occur during apoptosis (programmed cell death). The…”
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11 Unexpected New Insights Into ATM and p53 by Kastan, M, Valentin-Vega, Y, Chen, J

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Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks by Wang, Qinhong, Goldstein, Michael, Alexander, Peter, Wakeman, Timothy P, Sun, Tao, Feng, Junjie, Lou, Zhenkun, Kastan, Michael B, Wang, Xiao-Fan

“…The MRE11‐RAD50‐NBS1 (MRN) complex is essential for the detection of DNA double‐strand breaks (DSBs) and initiation of DNA damage signaling. Here, we show that…”
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Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation by Koumenis, Constantinos, Alarcon, Rodolfo, Hammond, Ester, Sutphin, Patrick, Hoffman, William, Murphy, Maureen, Derr, Jennifer, Taya, Yoichi, Lowe, Scott W., Kastan, Michael, Giaccia, Amato

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The many substrates and functions of ATM by Kastan, Michael B, Lim, Dae-sik

“…As its name suggests, the ATM--'ataxia-telangiectasia, mutated'--gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various…”
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Wild-Type p53 is a Cell Cycle Checkpoint Determinant Following Irradiation by Kuerbitz, Steven J., Plunkett, Beverly S., Walsh, William V., Kastan, Michael B.

“…Cell cycle checkpoints appear to contribute to an increase in cell survival and a decrease in abnormal heritable genetic changes following exposure to DNA…”
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Participation of p53 protein in the cellular response to DNA damage by KASTAN, M. B, ONYEKWERE, O, SIDRANSKY, D, VOGELSTEIN, B, CRAIG, R. W

“…The inhibition of replicative DNA synthesis that follows DNA damage may be critical for avoiding genetic lesions that could contribute to cellular…”
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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway by Kitagawa, Risa, Bakkenist, Christopher J, McKinnon, Peter J, Kastan, Michael B

“…The ATM protein kinase is activated by intermolecular autophosphorylation in response to DNA damage and initiates cellular signaling pathways that facilitate…”
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