Search Results - "Kastan, Jonathan P."

Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling by Brown, Michael C., Mosaheb, Mubeen M., Mohme, Malte, McKay, Zachary P., Holl, Eda K., Kastan, Jonathan P., Yang, Yuanfan, Beasley, Georgia M., Hwang, E. Shelley, Ashley, David M., Bigner, Darell D., Nair, Smita K., Gromeier, Matthias

“…Activating intra-tumor innate immunity might enhance tumor immune surveillance. Virotherapy is proposed to achieve tumor cell killing, while indirectly…”
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PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling by Dobrikov, Mikhail I, Dobrikova, Elena Y, McKay, Zachary P, Kastan, Jonathan P, Brown, Michael C, Gromeier, Matthias

“…For RNA virus families except , viral RNA sensing includes Toll-like receptors and/or RIG-I. Picornavirus RNAs, whose 5' termini are shielded by a…”
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Enterovirus 2A pro Cleavage of the YTHDF m 6 A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling by Kastan, Jonathan P, Tremblay, Martine W, Brown, Michael C, Trimarco, Joseph D, Dobrikova, Elena Y, Dobrikov, Mikhail I, Gromeier, Matthias

“…Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host cell manipulation. Here, we report that EV 2A proteases cleave all…”
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CReP mediates selective translation initiation at the endoplasmic reticulum by Kastan, Jonathan P, Dobrikova, Elena Y, Bryant, Jeffrey D, Gromeier, Matthias

“…Eukaryotic protein synthesis control at multiple levels allows for dynamic, selective responses to diverse conditions, but spatial organization of translation…”
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Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling by Kastan, Jonathan P, Tremblay, Martine W, Brown, Michael C, Trimarco, Joseph D, Dobrikova, Elena Y, Dobrikov, Mikhail I, Gromeier, Matthias

“…Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host cell manipulation. Here, we report that EV 2A proteases cleave all…”
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Abstract B008: Secretome labeling identifies gelsolin as a potential pro-tumorigenic PDAC biomarker by Kastan, Jonathan P., Standring, Oliver, Cifani, Paolo, Gaeth, Victoria, Jensen, Amanda, Park, Youngkyu, Tuveson, David

“…Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is a highly lethal malignancy with a 5-year survival rate around 10% due to late detection and therapeutic…”
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Abstract 2974: A complex of tumor-suppressor NF1 and SPRED2 promotes pancreatic cancer tumorigenesis by Kim, Sunny, Kastan, Jonathan P., Ting, Hsiu-Chi, Park, Youngkyu, Tuveson, Dave

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with poor prognosis due to late detection and lack of effective therapeutic…”
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