Search Results - "Kassir, Suham A."

Synthesis, in vitro and in vivo evaluation of [11C]MMTP: A potential PET ligand for mGluR1 receptors by Prabhakaran, Jaya, Majo, Vattoly J., Milak, Matthew S., Kassir, Suham A., Palner, Mikael, Savenkova, Lyudmila, Mali, Pratap, Arango, Victoria, Mann, J. John, Parsey, Ramin V., Kumar, J.S. Dileep

“…Synthesis, in vitro and in vivo evaluation of [O-methyl-11C]dimethylamino-3(4-methoxyphenyl)-3H-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-one (1), a potential…”
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Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity by Underwood, Mark D., Kassir, Suham A., Bakalian, Mihran J., Galfalvy, Hanga, Dwork, Andrew J., Mann, J. John, Arango, Victoria

“…Serotonin neurotransmitter deficits are reported in suicide, major depressive disorder (MDD) and alcohol use disorder (AUD). To compare pathophysiology in…”
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Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nuclei by Chamas, Firas M, Underwood, Mark D, Arango, Victoria, Serova, Lidia, Kassir, Suham A, Mann, John J, Sabban, Esther L

“…Stress triggers adaptive and maladaptive changes in the central nervous system, including activation of the hypothalamic–pituitary–adrenal axis, and can…”
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Dysregulation of Striatal Dopamine Receptor Binding in Suicide by Fitzgerald, Megan L, Kassir, Suham A, Underwood, Mark D, Bakalian, Mihran J, Mann, J John, Arango, Victoria

“…Inconsistent evidence implicates disruptions of striatal dopaminergic indices in suicide and major depression. To determine whether there are alterations in…”
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5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression by Steinberg, Louisa J., Underwood, Mark D., Bakalian, Mihran J., Kassir, Suham A., Mann, J. John, Arango, Victoria

“…Serotonergic system abnormalities are implicated in many psychiatric disorders, including major depression. The temporal lobe receives a high density of…”
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Less NMDA Receptor Binding in Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex Associated With Reported Early-Life Adversity but Not Suicide by Underwood, Mark D, Bakalian, Mihran J, Johnson, Virginia L, Kassir, Suham A, Ellis, Steven P, Mann, J John, Arango, Victoria

“…Glutamate is an excitatory neurotransmitter binding to 3 classes of receptors, including the N-methyl, D-aspartate (NMDA) receptor. NMDA receptor binding is…”
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Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides by Vinod, K. Yaragudri, Kassir, Suham A, Hungund, Basalingappa L, Cooper, Thomas B, Mann, J. John, Arango, Victoria

“…Abstract Recent studies in rodents have suggested a role for the central endocannabinoid system in the regulation of mood and alcohol related behaviors…”
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Neuron density and serotonin receptor binding in prefrontal cortex in suicide by Underwood, Mark D., Kassir, Suham A., Bakalian, Mihran J., Galfalvy, Hanga, Mann, J. John, Arango, Victoria

“…Although serotonin receptor and cytoarchitectonic alterations are reported in prefrontal cortex (PFC) in suicide and depression, no study has considered…”
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Neuronal Tryptophan Hydroxylase mRNA Expression in the Human Dorsal and Median Raphe Nuclei: Major Depression and Suicide by BACH-MIZRACHI, Helene, UNDERWOOD, Mark D, KASSIR, Suham A, BAKALIAN, Mihran J, SIBILLE, Etienne, TAMIR, Hadassah, MANN, J. John, ARANGO, Victoria

“…Major depressive disorder (MDD) and suicide are associated with deficient serotonergic neurotransmission. Tryptophan hydroxylase (TPH) is the rate-limiting…”
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Alcoholics Have More Tryptophan Hydroxylase 2 mRNA and Protein in the Dorsal and Median Raphe Nuclei by Bach, Helene, Arango, Victoria, Kassir, Suham A., Tsaava, Tea, Dwork, Andrew J., Mann, J. John, Underwood, Mark D.

“…Background Chronic alcohol use depletes brain serotonin (5‐hydroxytryptamine [5‐HT]), yet we previously found more tryptophan hydroxylase 2 (TPH2), the…”
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5-HT 1A receptor, 5-HT 2A receptor and serotonin transporter binding in the human auditory cortex in depression by Steinberg, Louisa J., MD, PhD, Underwood, Mark D., PhD, Bakalian, Mihran J., BA, Kassir, Suham A., BSc, Mann, J. John, MD, Arango, Victoria, PhD

“…ABSTRACTBackgroundSerotonergic system abnormalities are implicated in many psychiatric disorders, including major depression. The temporal lobe receives a high…”
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Synthesis and in vitro evaluation of [18F]FECIMBI-36: A potential agonist PET ligand for 5-HT2A/2C receptors by Prabhakaran, Jaya, Underwood, Mark D., Kumar, J.S. Dileep, Simpson, Norman R., Kassir, Suham A., Bakalian, Mihran J., Mann, J. John, Arango, Victoria

“…[Display omitted] Radiosynthesis and in vitro evaluation of [18F]-2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-(2-fluoroethoxy)benzyl)ethanamine, ([18F]FECIMBI-36) or…”
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Elevated levels of endocannabinoids and CB1 receptor-mediated G-protein signaling in the prefrontal cortex of alcoholic suicide victims by YARAGUDRI VINOD, K, ARANGO, Victoria, SHAN XIE, KASSIR, Suham A, MANN, J. John, COOPER, Thomas B, HUNGUND, Basalingappa L

“…Alcoholism is often comorbid with mood disorders and suicide. We recently reported an upregulation of CB(1) receptor-mediated signaling in the dorsolateral…”
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Serotonin 1A Receptors, Serotonin Transporter Binding and Serotonin Transporter mRNA Expression in the Brainstem of Depressed Suicide Victims by Arango, Victoria, Underwood, Mark D, Boldrini, Maura, Tamir, Hadassah, Kassir, Suham A, Hsiung, Shu-chi, Chen, Jason J.-X, Mann, J.John

“…Suicide and depression are associated with reduced serotonergic neurotransmission. In suicides, there is a reduction in serotonin transporter (SERT) sites and…”
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Synthesis of [O-methyl-11C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide: a potential PET ligand for CB1 receptors by Kumar, J S Dileep, Prabhakaran, Jaya, Arango, Victoria, Parsey, Ramin V, Underwood, Mark D, Simpson, Norman R, Kassir, Suham A, Majo, Vattoly J, Van Heertum, Ronald L, Mann, J John

“…Synthesis and in vitro evaluation of [O-methyl-(11)C]1-(2-chlorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide…”
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Cigarette Smoking and Tryptophan Hydroxylase 2 mRNA in the Dorsal Raphe Nucleus in Suicides by Bach, Helene, Arango, Victoria, Kassir, Suham A., Dwork, Andrew J., Mann, J. John, Underwood, Mark D.

“…Cigarette smoking is associated with suicide and mood disorders and stimulates serotonin release. Tryptophan hydroxylase (TPH2) synthesizes serotonin and is…”
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Higher postmortem prefrontal 5-HT2A receptor binding correlates with lifetime aggression in suicide by OQUENDO, Maria A, RUSSO, Stefani A, UNDERWOOD, Mark D, KASSIR, Suham A, ELLIS, Steven P, MANN, J. John, ARANGO, Victoria

“…In vivo studies find altered serotonin function associated with aggressive and suicidal behaviors. Postmortem studies also reveal serotonergic alterations in…”
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Synthesis and in vitro evaluation of [18F]BMS-754807: A potential PET ligand for IGF-1R by Majo, Vattoly J., Arango, Victoria, Simpson, Norman R., Prabhakaran, Jaya, Kassir, Suham A., Underwood, Mark D., Bakalian, Mihran, Canoll, Peter, John Mann, J., Dileep Kumar, J.S.

“…Radiosynthesis and in vitro evaluation of…”
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Autoradiographic evaluation of [3H]CUMI-101, a novel, selective 5-HT1AR ligand in human and baboon brain by Kumar, J.S. Dileep, Parsey, Ramin V., Kassir, Suham A., Majo, Vattoly J., Milak, Matthew S., Prabhakaran, Jaya, Simpson, Norman R., Underwood, Mark D., Mann, J. John, Arango, Victoria

“…[11C]CUMI-101 is the first selective serotonin receptor (5-HT1AR) partial agonist radiotracer for positron emission tomography (PET) tested in vivo in nonhuman…”
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Autoradiographic Evaluation of [18F]FECUMI-101, a High Affinity 5‑HT1AR Ligand in Human Brain by Kumar, J. S. Dileep, Underwood, Mark D, Simpson, Norman R, Kassir, Suham A, Prabhakaran, Jaya, Majo, Vattoly J, Bakalian, Mihran J, Parsey, Ramin V, Mann, J. John, Arango, Victoria

“…[18F]­FECUMI-101 ([18F]1) is a 5HT1AR ligand demonstrating specific binding in brain regions corresponding to the distribution of 5-HT1AR in baboons. However,…”
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