Aloe juvenna Brandham & S.Carter as α‐Amylase Inhibitor and Hypoglycaemic Agent with Anti‐inflammatory Properties for Diabetes Management

Despite Aloe’s traditional use, Aloe juvenna Brandham & S.Carter is poorly characterized. Other Aloes are known for their antidiabetic activity. This study describes the antidiabetic potentials and phytoconstituents of the A. juvenna leaves methanolic extract (AJME). Twenty‐six phytoconstituents...

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Bibliographic Details
Published in:	Chemistry & biodiversity Vol. 21; no. 5; pp. e202400245 - n/a
Main Authors:	El‐Mouty Raslan, Mona Abd, Kassem, Iman AbdelKhalek AbdelKhalek, Ghaly, Neveen Sabry, El‐Manawaty, May Aly, Melek, Farouk Rasmy, Nabil, Marian
Format:	Journal Article
Language:	English
Published:	Switzerland Wiley Subscription Services, Inc 01-05-2024
Subjects:	Aloe Aloe - chemistry Aloe juvenna alpha-Amylases - antagonists & inhibitors alpha-Amylases - metabolism Amylases Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology antidiabetic activity Column chromatography Diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diet Diet, High-Fat Dose-Response Relationship, Drug Glucosidase Glycoside Hydrolase Inhibitors - chemistry Glycoside Hydrolase Inhibitors - isolation & purification Glycoside Hydrolase Inhibitors - pharmacology High fat diet High performance liquid chromatography Hyperglycemia Hypoglycemic Agents - chemistry Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology In vivo methods and tests Inflammation Interleukin 6 Liquid chromatography Male Matrix metalloproteinase Matrix metalloproteinases Metalloproteinase natural products Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves - chemistry Rats Rats, Sprague-Dawley Streptozocin Xanthorrhoeaceae α-Amylase natural products liquid chromatography Aloe juvenna Xanthorrhoeaceae antidiabetic activity
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Summary:	Despite Aloe’s traditional use, Aloe juvenna Brandham & S.Carter is poorly characterized. Other Aloes are known for their antidiabetic activity. This study describes the antidiabetic potentials and phytoconstituents of the A. juvenna leaves methanolic extract (AJME). Twenty‐six phytoconstituents of AJME were described using HPLC/MS‐MS. Lupeol and vitexin were isolated using column chromatography. The antidiabetic activity of AJME was investigated using an in vivo high‐fat diet/streptozotocin‐induced diabetic rat model and in vitro α‐glucosidase and α‐amylase inhibitory activity assays. AJME demonstrated its α‐amylase inhibitory activity (IC50=313±39.9 ppm) with no effect on α‐glucosidase. In vivo, AJME dose‐dependently improved hyperglycaemia in a high‐fat diet/streptozotocin‐induced diabetic rat model. Notably, the higher dose (1600 mg/kg) of AJME significantly downregulated serum interleukin‐6, tumor necrosis factor‐α, and matrix metalloproteinase‐1 genes, suggesting its anti‐inflammatory effect. These findings indicate AJME′s potential as a significant antidiabetic agent through its α‐amylase inhibition, hypoglycaemic, and anti‐inflammatory properties.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1612-1872 1612-1880
DOI:	10.1002/cbdv.202400245