Search Results - "Kassardjian, Audrey"

Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses by Kassardjian, Audrey, Sun, Eric, Sookhoo, Jamie, Muthuraman, Krithika, Boligan, Kayluz Frias, Kucharska, Iga, Rujas, Edurne, Jetha, Arif, Branch, Donald R., Babiuk, Shawn, Barber, Brian, Julien, Jean-Philippe

“…Subunit vaccines typically require co-administration with an adjuvant to elicit protective immunity, adding development hurdles that can impede rapid pandemic…”
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Humanization of Pan-HLA-DR mAb 44H10 Hinges on Critical Residues in the Antibody Framework by Kassardjian, Audrey, Ivanochko, Danton, Barber, Brian, Jetha, Arif, Julien, Jean-Philippe

“…Reducing the immunogenicity of animal-derived monoclonal antibodies (mAbs) for use in humans is critical to maximize therapeutic effectiveness and preclude…”
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Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein by Thai, Elaine, Murugan, Rajagopal, Binter, Špela, Burn Aschner, Clare, Prieto, Katherine, Kassardjian, Audrey, Obraztsova, Anna S., Kang, Ryu Won, Flores-Garcia, Yevel, Mathis-Torres, Shamika, Li, Kan, Horn, Gillian Q., Huntwork, Richard H.C., Bolscher, Judith M., de Bruijni, Marloes H.C., Sauerwein, Robert, Dennison, S. Moses, Tomaras, Georgia D., Zavala, Fidel, Kellam, Paul, Wardemann, Hedda, Julien, Jean-Philippe

“…IGHV3-33-encoded antibodies are prevalent in the human humoral response against the Plasmodium falciparum circumsporozoite protein (PfCSP). Among VH3-33…”
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B cell targeting by molecular adjuvants for enhanced immunogenicity by Sicard, Taylor, Kassardjian, Audrey, Julien, Jean-Philippe

“…Adjuvants are critical components of vaccines to improve the quality and durability of immune responses. Molecular adjuvants are a specific subclass of…”
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Vaccination against Clostridium difficile by Use of an Attenuated Salmonella enterica Serovar Typhimurium Vector (YS1646) Protects Mice from Lethal Challenge by Winter, Kaitlin, Xing, Li, Kassardjian, Audrey, Ward, Brian J

“…disease is mediated primarily by toxins A and B (TcdA and TcdB, respectively). The receptor binding domains (RBD) of TcdA and TcdB are immunogenic, and…”
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Antibody-Based Platform for Targeted Delivery to Antigen-Presenting Cells by Kassardjian, Audrey Marielle

“…Despite remarkable scientific advances in the development of effective vaccines against a myriad of pathogens, the elusiveness of vaccines against certain…”
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