Search Results - "Kassab, Ghassan S."

Role of shear stress and stretch in vascular mechanobiology by Lu, Deshun, Kassab, Ghassan S.

“…Blood vessels are under constant mechanical loading from blood pressure and flow which cause internal stresses (endothelial shear stress and circumferential…”
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Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease by Labarrere, Carlos A, Kassab, Ghassan S

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 19 (COVID-19) has numerous risk factors leading to severe disease…”
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Intraspecific scaling laws of vascular trees by Huo, Yunlong, Kassab, Ghassan S.

“…A fundamental physics-based derivation of intraspecific scaling laws of vascular trees has not been previously realized. Here, we provide such a theoretical…”
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Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation by Labarrere, Carlos A, Kassab, Ghassan S

“…Many local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmonary disease, atherosclerosis with…”
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Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities by Zhong, Liang, Zhang, Jun-Mei, Su, Boyang, Tan, Ru San, Allen, John C, Kassab, Ghassan S

“…The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to the challenging field of virtual design and testing of technologies in…”
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Pattern Recognition Proteins: First Line of Defense Against Coronaviruses by Labarrere, Carlos A, Kassab, Ghassan S

“…The rapid outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 in Wuhan, China, has become a worldwide pandemic affecting almost 204 million people…”
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Response: Commentary: Pattern Recognition Proteins: First Line of Defense Against Coronaviruses by Labarrere, Carlos Alberto, Kassab, Ghassan S

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Why is the subendocardium more vulnerable to ischemia? A new paradigm by Algranati, Dotan, Kassab, Ghassan S, Lanir, Yoram

“…Myocardial ischemia is transmurally heterogeneous where the subendocardium is at higher risk. Stenosis induces reduced perfusion pressure, blood flow…”
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Efficacy and Mechanisms of Gastric Volume-Restriction Bariatric Devices by Wang, Yanmin, Kassab, Ghassan S.

“…Obesity is a chronic disease that affects over 795 million people worldwide. Bariatric surgery is an effective therapy to combat the epidemic of clinically…”
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Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta by Labarrere, Carlos A., MD, DiCarlo, Hector L., MD, Bammerlin, Elaine, MA, Hardin, James W., PhD, Kim, Yeon M., MD, Chaemsaithong, Piya, MD, Haas, David M., MD, MS, Kassab, Ghassan S., PhD, Romero, Roberto, MD, DMedSci

“…Background Failure of physiologic transformation of spiral arteries has been reported in preeclampsia, fetal growth restriction, fetal death, and spontaneous…”
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Conduit design with expanding diameter for enhanced flow by Hashemi, Javad, Peeples, Hunter, Kuykendall, Riley, Raju, Seshadri, Kassab, Ghassan S.

“…Conduits are commonly used for treating lesions in arteries and veins. The conventional stents are cylindrical in shape, which increases flow resistance with…”
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Thrombogenic and Inflammatory Reactions to Biomaterials in Medical Devices by Labarrere, Carlos A, Dabiri, Ali E, Kassab, Ghassan S

“…Blood-contacting medical devices of different biomaterials are often used to treat various cardiovascular diseases. Thrombus formation is a common cause of…”
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Numerical Simulations of MitraClip Placement: Clinical Implications by Kamakoti, Ramji, Dabiri, Yaghoub, Wang, Dee Dee, Guccione, Julius, Kassab, Ghassan S.

“…Mitral regurgitation (MR) is the most common type of valvular heart disease in patients over the age of 75 in the US. Despite the prevalence of mitral…”
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The Layered Structure of Coronary Adventitia under Mechanical Load by Chen, Huan, Liu, Yi, Slipchenko, Mikhail N., Zhao, Xuefeng, Cheng, Ji-Xin, Kassab, Ghassan S.

“…The mechanical loading-deformation relation of elastin and collagen fibril bundles is fundamental to understanding the microstructural properties of tissue…”
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Scaling laws of vascular trees: of form and function by Kassab, Ghassan S

“…The branching pattern and vascular geometry of biological tree structure are complex. Here we show that the design of all vascular trees for which there exist…”
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Electrical Conductance Device for Stent Sizing by Kassab, Ghassan S

“…The minimum stent area (MSA) has been clinically established as a significant predictor of restenosis, thrombosis, and ischemia using intra-vascular ultrasound…”
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Novel temperature responsive polymer based sealant for embolization by Dabiri, Ali E, Narain, Ravin, Peng, Yi-Yang, Wang, Wenda, Itkins, Max, Kassab, Ghassan S

“…A sealant has been developed that improves upon current catheter-based treatments in the following ways: 1) Efficient delivery system, 2) No in situ…”
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Study of Coronary Atherosclerosis Using Blood Residence Time by Hashemi, Javad, Patel, Bhavesh, Chatzizisis, Yiannis S, Kassab, Ghassan S

“…Computational fluid dynamic-based modeling is commonly used in stenosed and stented coronary artery to characterize blood flow and identify hemodynamics…”
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Increased Serum Klotho With Age-Related Aortic Stiffness and Peripheral Vascular Resistance in Young and Middle-Aged Swine by Guo, Xiaomei, Kassab, Ghassan S

“…The anti-aging function of Klotho gene has been implicated in age-related diseases. The physiological importance of Klotho in the progression of arterial…”
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Roles of Gastric Emptying and Gastrointestinal Transit Following Ileal Interposition in Alleviating Diabetes in Goto-Kakizaki Rats by Wang, Yanmin, Guo, Xiaomei, Sun, Dong, Kassab, Ghassan S

“…This study aimed to determine the change of gastrointestinal (GI) emptying time after ileal interposition (IT) and elucidate the role of altered GI peristalsis…”
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