Search Results - "Kassab, Ghassan"

Role of shear stress and stretch in vascular mechanobiology by Lu, Deshun, Kassab, Ghassan S.

“…Blood vessels are under constant mechanical loading from blood pressure and flow which cause internal stresses (endothelial shear stress and circumferential…”
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Microstructure-based biomechanics of coronary arteries in health and disease by Chen, Huan, Kassab, Ghassan S

“…Abstract Coronary atherosclerosis is the major cause of mortality and disability in developed nations. A deeper understanding of mechanical properties of…”
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Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease by Labarrere, Carlos A, Kassab, Ghassan S

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 19 (COVID-19) has numerous risk factors leading to severe disease…”
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Intraspecific scaling laws of vascular trees by Huo, Yunlong, Kassab, Ghassan S.

“…A fundamental physics-based derivation of intraspecific scaling laws of vascular trees has not been previously realized. Here, we provide such a theoretical…”
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Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation by Labarrere, Carlos A, Kassab, Ghassan S

“…Many local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmonary disease, atherosclerosis with…”
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Scaling Laws of Coronary Circulation in Health and Disease by Huo, Yunlong, Kassab, Ghassan S

“…Abstract The heterogeneity and complexity of coronary vasculature (structure) and myocardial flow (function) have fractal-like characteristics and can be…”
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Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta by Labarrere, Carlos A., MD, DiCarlo, Hector L., MD, Bammerlin, Elaine, MA, Hardin, James W., PhD, Kim, Yeon M., MD, Chaemsaithong, Piya, MD, Haas, David M., MD, MS, Kassab, Ghassan S., PhD, Romero, Roberto, MD, DMedSci

“…Background Failure of physiologic transformation of spiral arteries has been reported in preeclampsia, fetal growth restriction, fetal death, and spontaneous…”
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Integrative model of coronary flow in anatomically based vasculature under myogenic, shear, and metabolic regulation by Namani, Ravi, Kassab, Ghassan S, Lanir, Yoram

“…Coronary blood flow is regulated to match the oxygen demand of myocytes in the heart wall. Flow regulation is essential to meet the wide range of cardiac…”
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Mechanisms of coronary sinus reducer for treatment of myocardial ischemia: in silico study by Wang, Haifeng, Fan, Lei, Choy, Jenny S, Kassab, Ghassan S, Lee, Lik Chuan

“…The coronary sinus reducer (CSR) is an emerging medical device for treating patients with refractory angina, often associated with myocardial ischemia…”
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Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities by Zhong, Liang, Zhang, Jun-Mei, Su, Boyang, Tan, Ru San, Allen, John C, Kassab, Ghassan S

“…The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to the challenging field of virtual design and testing of technologies in…”
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In vivo self-assembly of small diameter pulmonary visceral pleura artery graft by Lu, Xiao, Han, Ling, Kassab, Ghassan S.

“…[Display omitted] There is a significant clinical need for small vascular grafts <1 mm in diameter. The structure and composition of swine pulmonary visceral…”
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Pattern Recognition Proteins: First Line of Defense Against Coronaviruses by Labarrere, Carlos A, Kassab, Ghassan S

“…The rapid outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 in Wuhan, China, has become a worldwide pandemic affecting almost 204 million people…”
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Response: Commentary: Pattern Recognition Proteins: First Line of Defense Against Coronaviruses by Labarrere, Carlos Alberto, Kassab, Ghassan S

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Why is the subendocardium more vulnerable to ischemia? A new paradigm by Algranati, Dotan, Kassab, Ghassan S, Lanir, Yoram

“…Myocardial ischemia is transmurally heterogeneous where the subendocardium is at higher risk. Stenosis induces reduced perfusion pressure, blood flow…”
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Efficacy and Mechanisms of Gastric Volume-Restriction Bariatric Devices by Wang, Yanmin, Kassab, Ghassan S.

“…Obesity is a chronic disease that affects over 795 million people worldwide. Bariatric surgery is an effective therapy to combat the epidemic of clinically…”
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The Layered Structure of Coronary Adventitia under Mechanical Load by Chen, Huan, Liu, Yi, Slipchenko, Mikhail N., Zhao, Xuefeng, Cheng, Ji-Xin, Kassab, Ghassan S.

“…The mechanical loading-deformation relation of elastin and collagen fibril bundles is fundamental to understanding the microstructural properties of tissue…”
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Conduit design with expanding diameter for enhanced flow by Hashemi, Javad, Peeples, Hunter, Kuykendall, Riley, Raju, Seshadri, Kassab, Ghassan S.

“…Conduits are commonly used for treating lesions in arteries and veins. The conventional stents are cylindrical in shape, which increases flow resistance with…”
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Thrombogenic and Inflammatory Reactions to Biomaterials in Medical Devices by Labarrere, Carlos A, Dabiri, Ali E, Kassab, Ghassan S

“…Blood-contacting medical devices of different biomaterials are often used to treat various cardiovascular diseases. Thrombus formation is a common cause of…”
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Resliced image space construction for coronary artery collagen fibers by Luo, Tong, Chen, Huan, Kassab, Ghassan S

“…Collagen fibers play an important role in the biomechanics of the blood vessel wall. The objective of this study was to determine the 3D microstructure of…”
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Hemodynamics in Coronary Arterial Tree of Serial Stenoses by Chen, Xi, Gao, Yang, Lu, Bin, Jia, Xinwei, Zhong, Liang, Kassab, Ghassan S, Tan, Wenchang, Huo, Yunlong

“…Serial segmental narrowing frequently occurs in humans, which alters coronary hemodynamics and further affects atherosclerotic progression and plaque…”
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