Search Results - "Kass, George E.N"

New approach methodologies in human regulatory toxicology – Not if, but how and when by Schmeisser, Sebastian, Miccoli, Andrea, von Bergen, Martin, Berggren, Elisabet, Braeuning, Albert, Busch, Wibke, Desaintes, Christian, Gourmelon, Anne, Grafström, Roland, Harrill, Joshua, Hartung, Thomas, Herzler, Matthias, Kass, George E.N., Kleinstreuer, Nicole, Leist, Marcel, Luijten, Mirjam, Marx-Stoelting, Philip, Poetz, Oliver, van Ravenzwaay, Bennard, Roggeband, Rob, Rogiers, Vera, Roth, Adrian, Sanders, Pascal, Thomas, Russell S., Marie Vinggaard, Anne, Vinken, Mathieu, van de Water, Bob, Luch, Andreas, Tralau, Tewes

“…The predominantly animal-centric approach of chemical safety assessment has increasingly come under pressure. Society is questioning overall performance,…”
Get full text

Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures by Vanhaecke, Tamara, Henkens, Tom, Kass, George E.N, Rogiers, Vera

“…Acetylation and deacetylation of histones, catalysed by histone acetyl transferases and histone deacetylases (HDAC), respectively, are known to be involved in…”
Get full text

The mitochondrial death pathway: a promising therapeutic target in diseases by Gupta, Sanjeev, Kass, George E.N., Szegezdi, Eva, Joseph, Bertrand

“…•  Introduction •  Mitochondria and cell death •  Mitochondrial outer membrane permeabilization (MOMP): point of no return ‐  MOMP by BCL‐2 family proteins ‐ …”
Get full text

[Corrigendum] What is considered cardiotoxicity of anthracyclines in animal studies by Georgiadis, Nikolaos, Tsarouhas, Konstantinos, Rezaee, Ramin, Nepka, Haritini, Kass, George E N, Dorne, Jean-Lou C M, Stagos, Dimitrios, Toutouzas, Konstantinos, Spandidos, Demetrios A, Kouretas, Dimitrios, Tsitsimpikou, Christina

“…Subsequently to the publication of this paper, the authors have realized that the name of the seventh listed author, Dimitrios Stagos, was spelt incorrectly…”
Get full text

Role of Mitochondria in Drug-Induced Cholestatic Injury by Kass, George E.N., PhD, Price, Shirley C., PhD

“…Mitochondria have multiple functions in eukaryotic cells and are organized into dynamic tubular networks that continuously undergo changes through coordinated…”
Get full text

The ionic liquid 1-octyl-3-methylimidazolium (M8OI) is an activator of the human estrogen receptor alpha by Leitch, Alistair C., Lakey, Anne F., Hotham, William E., Agius, Loranne, Kass, George E.N., Blain, Peter G., Wright, Matthew C.

“…Recent environmental sampling around a landfill site in the UK demonstrated that unidentified xenoestrogens were present at higher levels than control sites;…”
Get full text

In vitro anti-inflammatory activity of Malus × domestica var. Mela Rosa Marchigiana pulp callus extract contrasting high glucose conditions by Benayada, Leila, Gubitosa, Federica, Fraternale, Daniele, Carloni, Silvia, Cerioni, Liana, Matacchione, Giulia, Olivieri, Fabiola, Potenza, Lucia, De Bellis, Roberta, Chiarantini, Laura, Roselli, Carla, Valentini, Laura, Gobbi, Pietro, Balduini, Walter, Pappagallo, Noemi, Ventura, Natascia, Kass, George E.N., Colomba, Mariastella, Albertini, Maria Cristina

“…[Display omitted] •Mela Rosa Marchigiana pulp callus extract (MRME) reduces inflammatory response.•MRME can contrast senescence or High Glucose-induced…”
Get full text

Long-lasting bioactive compounds production from Malus x domestica Borkh var. Mela Rosa Marchigiana pulp callus culture with antioxidant activity: In vitro, ex vivo and in vivo validation by Gubitosa, Federica, Benayada, Leila, Fraternale, Daniele, De Bellis, Roberta, Carloni, Silvia, Potenza, Lucia, Chiarantini, Laura, Gorassini, Andrea, Verardo, Giancarlo, Roselli, Carla, Valentini, Laura, Gobbi, Pietro, Balduini, Walter, Ventura, Natascia, Giannaccini, Francesca, Kass, George E.N., Colomba, Mariastella, Albertini, Maria Cristina

“…•Mela Rosa Marchigiana pulp callus cultures produce long-lasting bioactive compounds.•Mela Rosa Marchigiana pulp callus extract showed in vitro antioxidant…”
Get full text

B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals by Leitch, Alistair C, Probert, Philip M.E, Shayman, James A, Meyer, Stephanie K, Kass, George E.N, Wright, Matthew C

“…Abstract Lipid dysregulation is a common hepatic adverse outcome after exposure to toxic drugs and chemicals. A donor-free rat hepatocyte-like (B-13/H) cell…”
Get full text

Advancing human health risk assessment by Lanzoni, Anna, Castoldi, Anna F, Kass, George EN, Terron, Andrea, De Seze, Guilhem, Bal‐Price, Anna, Bois, Frédéric Y, Delclos, K Barry, Doerge, Daniel R, Fritsche, Ellen, Halldorsson, Thorhallur, Kolossa‐Gehring, Marike, Hougaard Bennekou, Susanne, Koning, Frits, Lampen, Alfonso, Leist, Marcel, Mantus, Ellen, Rousselle, Christophe, Siegrist, Michael, Steinberg, Pablo, Tritscher, Angelika, Van de Water, Bob, Vineis, Paolo, Walker, Nigel, Wallace, Heather, Whelan, Maurice, Younes, Maged

“…The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current…”
Get full text

TKPlate 1.0: An Open‐access platform for toxicokinetic and toxicodynamic modelling of chemicals to implement new approach methodologies in chemical risk assessment by Dorne, Jean Lou C. M., Cortiñas‐Abrahantes, José, Spyropoulos, Fotis, Darney, Keyvin, Lautz, Leonie, Louisse, Jochem, Kass, George E. N., Carnesecchi, Edoardo, Liem, A. K. Djien, Tarazona, José V., Billat, Pierre‐André, Beaudoin, Rémy, Zeman, Florence, Bodin, Cléo, Smith, Anthony, Nathanail, Alexis, Di Nicola, Matteo R., Kleiner, Juliane, Terron, Andrea, Parra‐Morte, Juan Manuel, Verloo, Didier, Robinson, Tobin

“…This publication is linked to the following EFSA Supporting Publications articles: http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2023.EN-8441/full,…”
Get full text

Effect of dietary copper supplementation on cell composition and apoptosis in atherosclerotic lesions of cholesterol-fed rabbits by Lamb, David J, Avades, Tony Y, Allen, Michael D, Anwar, Khurshid, Kass, George E.N, Ferns, Gordon A.A

“…We have previously shown that dietary copper supplementation modulates the formation of atherosclerotic lesions in the cholesterol-fed rabbit. In the present…”
Get full text

Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: Roles of cytochrome c, Bax, Bid, and caspases by El-Hassan, Hasan, Anwar, Khurshid, Macanas-Pirard, Patricia, Crabtree, Mark, Chow, Sek C, Johnson, Victoria L, Lee, Pauline C, Hinton, Richard H, Price, Shirley C, Kass, George E.N

“…The role of apoptosis in acetaminophen (AAP)-induced hepatic injury was investigated. Six hours after AAP administration to BALB/c mice, a significant loss of…”
Get full text

Live cell detection of caspase-3 activation by a Discosoma-red-fluorescent-protein-based fluorescence resonance energy transfer construct by Elphick, Lucy M., Meinander, Annika, Mikhailov, Andrey, Richard, Morgiane, Toms, Nick J., Eriksson, John E., Kass, George E.N.

“…A probe consisting of Discosoma red fluorescent protein (DsRed) and enhanced yellow fluorescent protein (EYFP) linked by a 19-amino-acid chain containing the…”
Get full text

Opposing roles for caspase and calpain death proteases in l -glutamate-induced oxidative neurotoxicity by Hawat, Mohammad, Kaksonen, Elina, Elphick, Lucy M, Toms, Nick J, Eriksson, John E, Kass, George E.N

Get full text

Dielectrophoresis: A new in vitro approach to measure drug-induced cytotoxicity by Hübner, Yvonne, Mulhall, Hayley, Hoettges, Kai F, Kass, George E.N, Ogin, Stephen L, Hughes, Michael P

Get full text

Vipers of Major clinical relevance in Europe: Taxonomy, venom composition, toxicology and clinical management of human bites by Di Nicola, Matteo R., Pontara, Andrea, Kass, George E.N., Kramer, Nynke I., Avella, Ignazio, Pampena, Riccardo, Mercuri, Santo Raffaele, Dorne, Jean Lou C.M., Paolino, Giovanni

“…•Taxonomic keys for identification of viper species.•Venom composition, mode of action of viper toxins.•Protocol for the clinical management of viper…”
Get full text

Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop by Westmoreland, Carl, Bender, Hans J., Doe, John E., Jacobs, Miriam N., Kass, George E.N., Madia, Federica, Mahony, Catherine, Manou, Irene, Maxwell, Gavin, Prieto, Pilar, Roggeband, Rob, Sobanski, Tomasz, Schütte, Katrin, Worth, Andrew P., Zvonar, Zvonimir, Cronin, Mark T.D.

“…New Approach Methodologies (NAMs) are considered to include any in vitro, in silico or chemistry-based method, as well as the strategies to implement them,…”
Get full text

Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals by More, Simon John, Bampidis, Vasileios, Benford, Diane, Bennekou, Susanne Hougaard, Bragard, Claude, Halldorsson, Thorhallur Ingi, Hernández‐Jerez, Antonio F, Koutsoumanis, Konstantinos, Naegeli, Hanspeter, Schlatter, Josef R, Silano, Vittorio, Nielsen, Søren Saxmose, Schrenk, Dieter, Turck, Dominique, Younes, Maged, Benfenati, Emilio, Castle, Laurence, Cedergreen, Nina, Hardy, Anthony, Laskowski, Ryszard, Leblanc, Jean Charles, Kortenkamp, Andreas, Ragas, Ad, Posthuma, Leo, Svendsen, Claus, Solecki, Roland, Testai, Emanuela, Dujardin, Bruno, Kass, George EN, Manini, Paola, Jeddi, Maryam Zare, Dorne, Jean‐Lou CM, Hogstrand, Christer

“…This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals for all relevant areas within EFSA's…”
Get full text

Implementing New Approach Methodologies (NAMs) in food safety assessments: Strategic objectives and actions taken by the European Food Safety Authority by Cattaneo, Irene, Astuto, Maria Chiara, Binaglia, Marco, Devos, Yann, Dorne, Jean Lou C.M., Fernandez Agudo, Ana, Fernandez Dumont, Antonio, Garcia-Vello, Pilar, Kass, George E.N., Lanzoni, Anna, Liem, A.K. Djien, Panzarea, Martina, Paraskevopulos, Konstantinos, Parra Morte, Juan Manuel, Tarazona, Jose V., Terron, Andrea

“…New Approach Methodologies (NAMs) comprise in silico and in vitro methods applied as alternative to animal testing. Even though NAMs are already fully…”
Get full text