Search Results - "Kasprzyk, Philip G"

In Vitro Evaluation of the Potential for Drug Interactions by Salidroside by Kasprzyk, Philip G., Tremaine, Larry, Fahmi, Odette A., Weng, Jing-Ke

“…Several studies utilizing Rhodiola rosea, which contains a complex mixture of phytochemicals, reported some positive drug-drug interaction (DDI) findings based…”
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Safety of a Sustainably Produced, Bioengineered, Nature-Identical Salidroside Compound by Kasprzyk, Philip G, Vickery, Christopher, Ye, Mingli, Sewastianik, Magdalena, Gong, Wei, Ding, Sheng, Dziwenka, Margitta, Mozingo, Amy, Valm, Kaiti, Schachner, Holly, Weng, Jing-Ke

“…Bioactive phytochemicals such as salidroside have been studied to understand the beneficial effects of , an herbaceous plant used in traditional medicine to…”
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STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1)/SV40 T/t-antigen transgenic mice by Meyer-Losic, Florence, Newman, Simon P, Day, Joanna M, Reed, Michael J, Kasprzyk, Philip G, Purohit, Atul, Foster, Paul A

“…Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor pharmacological profile,…”
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IRC‐083864, a novel bis quinone inhibitor of CDC25 phosphatases active against human cancer cells by Brezak, Marie‐Christine, Valette, Annie, Quaranta, Muriel, Contour‐Galcera, Marie‐Odile, Jullien, Denis, Lavergne, Olivier, Frongia, Céline, Bigg, Dennis, Kasprzyk, Philip G., Prevost, Grégoire Pierre, Ducommun, Bernard

“…CDC25 phosphatases are key actors in cyclin‐dependent kinases activation whose role is essential at various stages of the cell cycle. CDC25 expression is…”
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Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure by Dohle, Wolfgang, Jourdan, Fabrice L, Menchon, Grégory, Prota, Andrea E, Foster, Paul A, Mannion, Pascoe, Hamel, Ernest, Thomas, Mark P, Kasprzyk, Philip G, Ferrandis, Eric, Steinmetz, Michel O, Leese, Mathew P, Potter, Barry V. L

“…Quinazolinone-based anticancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series,…”
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Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of CDC25 phosphatases by Brezak, Marie-Christine, Quaranta, Muriel, Contour-Galcera, Marie-Odile, Lavergne, Olivier, Mondesert, Odile, Auvray, Pierrïck, Kasprzyk, Philip G, Prevost, Gregoire P, Ducommun, Bernard

“…Cell cycle regulators, such as the CDC25 phosphatases, are potential targets for the development of new anticancer drugs. Here we report the identification and…”
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IRC-083927 is a new tubulin binder that inhibits growth of human tumor cells resistant to standard tubulin-binding agents by Liberatore, Anne-Marie, Coulomb, Hélène, Pons, Dominique, Dutruel, Olivier, Kasprzyk, Philip G, Carlson, Mark, Nelson, Ann Savola, Newman, Simon P, Stengel, Chloe, Auvray, Pierrïck, Hesry, Vincent, Foll, Béatrice, Narboux, Nadine, Morlais, Delphine, Le Moing, Mélissa, Bernetiere, Sonia, Dellile, Raphael, Camara, Jose, Ferrandis, Eric, Bigg, Dennis C, Prévost, Grégoire P

“…Tubulin is a validated target for antitumor drugs. However, the effectiveness of these microtubule-interacting agents is limited by the fact that they are…”
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3,17-Disubstituted 2-Alkylestra-1,3,5(10)-trien-3-ol Derivatives:  Synthesis, In Vitro and In Vivo Anticancer Activity by Bubert, Christian, Leese, Mathew P, Mahon, Mary F, Ferrandis, Eric, Regis-Lydi, Sandra, Kasprzyk, Philip G, Newman, Simon P, Ho, Yaik T, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

“…Estradiol-3,17-O,O-bis-sulfamates inhibit steroid sulfatase (STS), carbonic anhydrase (CA), and, when substituted at C-2, cancer cell proliferation and…”
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Tetrahydroisoquinolinone-Based Steroidomimetic and Chimeric Microtubule Disruptors by Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Hamel, Ernest, Ferrandis, Eric, Fiore, Ann, Kasprzyk, Philip G., Potter, Barry V. L.

“…A structure–activity relationship (SAR) translation strategy was used for the discovery of tetrahydroisoquinoline (THIQ)‐based steroidomimetic and chimeric…”
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Synthesis, Antitubulin, and Antiproliferative SAR of C3/C1-Substituted Tetrahydroisoquinolines by Dohle, Wolfgang, Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Bai, Ruoli, Hamel, Ernest, Ferrandis, Eric, Kasprzyk, Philip G., Fiore, Ann, Newman, Simon P., Purohit, Atul, Potter, Barry V. L.

“…The syntheses and antiproliferative activities of novel substituted tetrahydroisoquinoline derivatives and their sulfamates are discussed. Biasing of…”
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Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric G alpha /G beta gamma Protein Complex by Prevost, Gregoire P, Lonchampt, Marie O, Holbeck, Susan, Attoub, Samir, Zaharevitz, Daniel, Alley, Mike, Wright, John, Brezak, Marie C, Coulomb, Helene, Savola, Ann, Huchet, Marion, Chaumeron, Sophie, Nguyen, Quang-De, gez, Patricia, Bruyneel, Erik, Bracke, Mark, Ferrandis, Eric, Roubert, Pierre, Demarquay, Daniele, Gespach, Christian, Kasprzyk, Philip G

“…A large number of hormones and local agonists activating guanine-binding protein-coupled receptors (GPCR) play a major role in cancer progression. Here, we…”
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Membrane structure modulation, protein kinase C alpha activation, and anticancer activity of minerval by Martínez, Jordi, Vögler, Oliver, Casas, Jesús, Barceló, Francisca, Alemany, Regina, Prades, Jesús, Nagy, Tünde, Baamonde, Carmela, Kasprzyk, Philip G, Terés, Silvia, Saus, Carlos, Escribá, Pablo V

“…Most drugs currently used for human therapy interact with proteins, altering their activity to modulate the pathological cell physiology. In contrast,…”
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Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Gα/Gβγ protein complex by PREVOST, Grégoire P, LONCHAMPT, Marie O, HUCHET, Marion, CHAUMERON, Sophie, NGUYEN, Quang-Dé, FORGEZ, Patricia, BRUYNEEL, Erik, BRACKE, Mark, FERRANDIS, Eric, ROUBERT, Pierre, DEMARQUAY, Danièle, GESPACH, Christian, HOLBECK, Susan, KASPRZYK, Philip G, ATTOUB, Samir, ZAHAREVITZ, Daniel, ALLEY, Mike, WRIGHT, John, BREZAK, Marie C, COULOMB, Hélène, SAVOLA, Ann

“…A large number of hormones and local agonists activating guanine-binding protein-coupled receptors (GPCR) play a major role in cancer progression. Here, we…”
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Cover Picture: Tetrahydroisoquinolinone-Based Steroidomimetic and Chimeric Microtubule Disruptors (ChemMedChem 1/2014) by Leese, Mathew P., Jourdan, Fabrice L., Major, Meriel R., Dohle, Wolfgang, Hamel, Ernest, Ferrandis, Eric, Fiore, Ann, Kasprzyk, Philip G., Potter, Barry V. L.

“…A structure-activity relationship (SAR) translation strategy was used for the discovery of tetrahydroisoquinoline (THIQ)-based steroidomimetic and chimeric…”
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2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique by Foster, Paul A., Ho, Yaik T., Newman, Simon P., Kasprzyk, Philip G., Leese, Mathew P., Potter, Barry V. L., Reed, Michael J., Purohit, Atul

“…Breast cancer is the leading cause of cancer deaths among women worldwide. The theory of targeting both cancer cells directly and their blood supply has…”
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A novel synthetic inhibitor of CDC25 phosphatases: BN82002 by BREZAK, Marie-Christine, QUARANTA, Muriel, LANCO, Christophe, KASPRZYK, Philip G, PREVOST, Gregoire P, DUCOMMUN, Bernard, MONDESERT, Odile, GALCERA, Marie-Odile, LAVERGNE, Olivier, ALBY, Frédéric, CAZALES, Martine, BALDIN, Véronique, THURIEAU, Christophe, HARNETT, Jeremiath

“…CDC25 dual-specificity phosphatases are essential regulators that dephosphorylate and activate cyclin-dependent kinase/cyclin complexes at key transitions of…”
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Homocamptothecins:  Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues by Lavergne, Olivier, Lesueur-Ginot, Laurence, Pla Rodas, Francesc, Kasprzyk, Philip G, Pommier, Jacques, Demarquay, Danièle, Prévost, Grégoire, Ulibarri, Gérard, Rolland, Alain, Schiano-Liberatore, Anne-Marie, Harnett, Jeremiah, Pons, Dominique, Camara, José, Bigg, Dennis C. H

“…Homocamptothecin (hCPT), a camptothecin (CPT) analogue with a seven membered β-hydroxylactone which combines enhanced plasma stability and potent topoisomerase…”
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AR36A36.11.1, a monoclonal antibody targeting CD59, enhances complement activity and exhibits potent in vivo efficacy in multiple human cancer models by Mak, Baldwin C., McConkey, Fortunata, Feng, Ningping, O’Reilly, Kevin, Rubinstein, Daniel, Kasprzyk, Philip G., Hahn, Susan E., Pereira, Daniel S., Findlay, Helen, Young, David S.

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IIn Vitro/I Evaluation of the Potential for Drug Interactions by Salidroside by Kasprzyk, Philip G, Tremaine, Larry, Fahmi, Odette A, Weng, Jing-Ke

“…Several studies utilizing Rhodiola rosea, which contains a complex mixture of phytochemicals, reported some positive drug-drug interaction (DDI) findings based…”
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Recombinant Anti-ErbB2 Immunotoxins Containing Pseudomonas Exotoxin by Batra, Janendra K., Kasprzyk, Philip G., Bird, Robert E., Pastan, Ira, King, C. Richter

“…Immunotoxins were made using five different murine monoclonal antibodies to the human erbB2 gene product and LysPE40, a 40-kDa recombinant form of Pseudomonas…”
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