A Library of Fluorinated Electrophiles for Chemical Tagging and Materials Synthesis

A Library of Fluorinated Electrophiles for Chemical Tagging and Materials Synthesis

Various applications could benefit from new fluorinated molecules that offer chemical handles for quickly functionalizing reactive surfaces and molecules. Herein, we report the synthesis of a library of fluorinated molecules that contain nonafluoro-tert-butyl groups and electrophilic handles, mostly...

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Bibliographic Details
Published in:Journal of organic chemistry Vol. 81; no. 17; pp. 8095 - 8103
Main Authors: Kasper, Jonathan J, Hitro, Jamie E, Fitzgerald, Sabrina R, Schnitter, Joseph M, Rutowski, James J, Heck, John A, Steinbacher, Jeremy L
Format: Journal Article
Language:English
Published: United States American Chemical Society 02-09-2016
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Summary:Various applications could benefit from new fluorinated molecules that offer chemical handles for quickly functionalizing reactive surfaces and molecules. Herein, we report the synthesis of a library of fluorinated molecules that contain nonafluoro-tert-butyl groups and electrophilic handles, mostly acrylates and acrylamides. Featuring a variety of hydrophobic and hydrophilic linkers, these molecules could find use in polymer chemistry, biomaterials, biomedical imaging, and protein tagging.
Bibliography:ObjectType-Article-1
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ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b01572