Search Results - "Kasper, Jonathan"

BETTER BASELINE VISION LEADS TO BETTER OUTCOMES AFTER THE 0.19-mg FLUOCINOLONE ACETONIDE INTRAVITREAL IMPLANT IN DIABETIC MACULAR EDEMA by Gonzalez, Victor H., Luo, Caesar, Almeida, David R.P., Cutino, Antonio, Coughlin, Brandon, Kasper, Jonathan, Kiernan, Daniel F.

“…Analysis of a 3-year, Phase 4, open-label, observational study evaluating the association of baseline best-corrected visual acuity (BCVA) with visual,…”
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Quantification of Mitochondrial Oxidative Phosphorylation in Metabolic Disease: Application to Type 2 Diabetes by Lewis, Matthew T, Kasper, Jonathan D, Bazil, Jason N, Frisbee, Jefferson C, Wiseman, Robert W

“…Type 2 diabetes (T2D) is a growing health concern with nearly 400 million affected worldwide as of 2014. T2D presents with hyperglycemia and insulin resistance…”
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Effects of altered pyruvate dehydrogenase activity on contracting skeletal muscle bioenergetics by Kasper, Jonathan D, Meyer, Ronald A, Beard, Daniel A, Wiseman, Robert W

“…During aerobic exercise (>65% of maximum oxygen consumption), the primary source of acetyl-CoA to fuel oxidative ATP synthesis in muscle is the pyruvate…”
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Type 2 diabetes mellitus in the Goto-Kakizaki rat impairs microvascular function and contributes to premature skeletal muscle fatigue by Frisbee, Jefferson C, Lewis, Matthew T, Kasper, Jonathan D, Chantler, Paul D, Wiseman, Robert W

“…Despite extensive investigation into the impact of metabolic disease on vascular function and, by extension, tissue perfusion and organ function, interpreting…”
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Skeletal muscle energetics are compromised only during high-intensity contractions in the Goto-Kakizaki rat model of type 2 diabetes by Lewis, Matthew T, Kasper, Jonathan D, Bazil, Jason N, Frisbee, Jefferson C, Wiseman, Robert W

“…Type 2 diabetes (T2D) presents with hyperglycemia and insulin resistance, affecting over 30 million people in the United States alone. Previous work has…”
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A Library of Fluorinated Electrophiles for Chemical Tagging and Materials Synthesis by Kasper, Jonathan J, Hitro, Jamie E, Fitzgerald, Sabrina R, Schnitter, Joseph M, Rutowski, James J, Heck, John A, Steinbacher, Jeremy L

“…Various applications could benefit from new fluorinated molecules that offer chemical handles for quickly functionalizing reactive surfaces and molecules…”
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The 0.19-mg Fluocinolone Acetonide Intravitreal Implant Reduces Treatment Burden in Diabetic Macular Edema by Merrill, Pauline T., Holekamp, Nancy, Roth, Daniel, Kasper, Jonathan, Grigorian, Ruben

“…To assess treatment burden in patients with diabetic macular edema (DME) after the 0.19-mg fluocinolone acetonide (FAc) intravitreal implant (ILUVIEN)…”
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Corrigendum to “The 0.19-mg Fluocinolone Acetonide Intravitreal Implant Reduces Treatment Burden in Diabetic Macular Edema” [Am J Ophthalmol 2023;248;16-23] by Merrill, Pauline T., Holekamp, Nancy, Roth, Daniel, Kasper, Jonathan, Grigorian, Ruben

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WED-212 Pemvidutide treatment is associated with improvement in non-invasive tests indicating greater likelihood of histologic response in subjects with metabolic dysfunction-associated steatotic liver disease: a 24-week, randomized, double-blind, placebo-controlled trial by Alkhouri, Naim, Tomah, Shaheen, Suschak, John, Kasper, Jonathan, Roberts, M. Scot, Harris, M. Scott, Browne, Sarah, Loomba, Rohit

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Type II Diabetes Mellitus in the Goto‐Kakizaki Rat Impairs Microvascular Function and Contributes to Premature Skeletal Muscle Fatigue by Frisbee, Jefferson, Lewis, Matthew, Kasper, Jonathan, Chantler, Paul, Wiseman, Robert

“…Despite extensive investigation into the impact of metabolic disease on vascular function and, by extension, tissue perfusion and organ function, interpreting…”
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WED-219 Pemvidutide, a glucagon-like peptide 1/glucagon dual receptor agonist, improves metabolic dysfunction-associated steatohepatitis activity and fibrosis in a clinical quantitative systems pharmacology model by Harrison, Stephen A., Suschak, John, McDaniel, Matthew, Kenz, Zackary, Tomah, Shaheen, Kasper, Jonathan, Roberts, M. Scot, Siler, Scott, Harris, M. Scott, Browne, Sarah

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Better baseline vision leads to better outcomes after the 0.19-mg fluocinolone acetonide intravitreal implant in diabetic macular edema by Gonzalez, Victor H., Luo, Caesar, Almeida, David R.P., Cutino, Antonio, Coughlin, Brandon, Kasper, Jonathan, Kiernan, Daniel F.

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Metabolic Demand Dictates Muscle Blood Flow and the Hyperemic Response to Low Intensity Exercise by Tonson, Anne, Kasper, Jonathan, Tanbakuchi, Daniel, Meyer, Ronald, Wiseman, Robert

“…This study aimed to 1) quantitatively resolve in vivo muscle blood flow dynamics in response to contractile activity and 2) characterize the relationship…”
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262-OR: Pemvidutide, a GLP-1/Glucagon Dual Receptor Agonist, in Subjects with Overweight or Obesity—A 48-Week, Placebo-Controlled, Phase 2 (MOMENTUM) Trial by ARONNE, LOUIS, SCOTT HARRIS, M., ROBERTS, M S., SUSCHAK, JOHN J., TOMAH, SHAHEEN, KASPER, JONATHAN, HE, LIANG, YANG, JAY, FRIAS, JUAN P., BROWNE, SARAH K.

“…Introduction & Objective: Pemvidutide is a GLP-1/glucagon dual receptor agonist in development for treatment of obesity. Methods: MOMENTUM was a Phase 2,…”
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Skeletal Muscle Mitochondrial Function in Goto‐Kakizaki Rat Model of Type 2 Diabetes by Lewis, Matthew T, Kasper, Jonathan D, Bazil, Jason N, Frisbee, Jefferson C, Meyer, Ronald A, Wiseman, Robert W

“…Type 2 diabetes (T2D) presents with significant comorbidities and reported exercise intolerance affecting over 30 million people in the US alone. Aerobic…”
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Ocular, Visual, and Anatomical Outcomes in Eyes Requiring Incisional Intraocular Pressure-Lowering Surgery Following the 0.19-mg Fluocinolone Acetonide Intravitreal Implant by Eichenbaum, David, Gonzalez, Victor H, Roth, Daniel, Fortun, Jorge, Radcliffe, Nathan M, Cutino, Antonio, Kasper, Jonathan, Coughlin, Brandon A, Arevalo, J Fernando

“…To assess ocular, visual, and anatomical outcomes following the 0.19-mg fluocinolone acetonide (FAc) intravitreal implant (ILUVIEN®) and incisional intraocular…”
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Pyruvate Dehydrogenase Activity in Red and Superficial White Gastrocnemius Muscles of the Rat during Contraction by Kasper, Jonathan D, Lewis, Matthew T, Gudziak, Gregory L, Meyer, Ronald A, Wiseman, Robert W

“…Abstract only The increase in glucose oxidation during exercise is dependent upon the mitochondrial enzyme pyruvate dehydrogenase (PDH) which is allosterically…”
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Skeletal Muscle Pyruvate Dehydrogenase Activity Follows the Cellular Energetic Status during Contraction by Kasper, Jonathan D, Lewis, Matthew T, Gudziak, Gregory L, Meyer, Ronald A, Wiseman, Robert W

“…Abstract only Pyruvate dehydrogenase (PDH) is a mitochondrial matrix enzyme that regulates glucose oxidation in skeletal muscle. The activation status of PDH…”
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Mathematical Modeling of Oxidative Phosphorylation Predicts in vivo Phosphorus Kinetics by Lewis, Matthew T, Kasper, Jonathan D, Bazil, Jason N, Meyer, Ronald A, Wiseman, Robert W

“…Abstract only Mitochondrial density is a key contributor to exercise capacity. Diseases such as diabetes and age related illnesses lower mitochondrial…”
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Long-Term Control of Retinal Thickness Variability and Vision Following the 0.19 mg Fluocinolone Acetonide Implant by Sheth, Veeral S., Singer, Michael, MacCumber, Mathew, Cutino, Antonio, Kasper, Jonathan, Coughlin, Brandon A., Riemann, Christopher D.

“…Purpose: To assess the impact of retinal thickness variability (RTV) control on visual and treatment burden outcomes in patients with diabetic macular edema…”
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