Search Results - "Kasparkova, J."

Comment on "Delivering a photosensitive transplatin prodrug to overcome cisplatin drug resistance" by H. Song, W. Li, R. Qi, L. Yan, X. Jing, M. Zheng and H. Xiao, Chem. Commun., 2015, 51, 11493 by Brabec, V, Vrana, O, Novakova, O, Kasparkova, J

“…Consistency of literature results with the transformation of trans-diamminedichloridoplatinum(ii) (transplatin) into cis-diammine-dichloridoplatinum(ii)…”
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Lichen secondary metabolites as DNA-interacting agents by Plsíkova, J., Stepankova, J., Kasparkova, J., Brabec, V., Backor, M., Kozurkova, M.

“…•Interactions of selected lichen secondary metabolites 1–4 with calf thymus DNA were studied.•Binding constants of 4.3×105–2.4×107M−1 were determined from…”
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Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity by Janockova, J, Zilecka, E, Kasparkova, J, Brabec, V, Soukup, O, Kuca, K, Kozurkova, M

“…In this paper, we describe the biochemical properties and biological activity of a series of cholinesterase reactivators (symmetrical bisquaternary…”
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Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex by Hrabina, O, Kasparkova, J, Suchankova, T, Novohradsky, V, Guo, Z, Brabec, Viktor

“…The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH ) Cl] (4,4'-methylenedianiline)} (1) play a prevalent role in its antitumor effects. Complex…”
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Sensitisation for cisplatin-induced apoptosis by isothiocyanate E-4IB leads to signalling pathways alterations by BODO, J, HUNAKOVA, L, KVASNICKA, P, JAKUBIKOVA, J, DURAJ, J, KASPARKOVA, J, SEDLAK, J

“…A new synthetic isothiocyanate (ITC) derivative, ethyl 4-isothiocyanatobutanoate (E-4IB), appeared to be an effective modulator of cellular proliferation and…”
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Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin by Kasparkova, Jana, Fojta, Miroslav, Farrell, Nicholas, Brabec, Viktor

“…The trinuclear platinum agent BBR3464, a representative of a new class of anticancer drugs, is more potent than conventional mononuclear cisplatin…”
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Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs by Brabec, Viktor, Kasparkova, Jana

“…The importance of platinum drugs in cancer chemotherapy is underscored by the clinical success of cisplatin [cis-diamminedichloroplatinum(II)] and its…”
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Double-check probing of DNA bending and unwinding by XPA-RPA: an architectural function in DNA repair by Missura, Miriam, Buterin, Tonko, Hindges, Robert, Hübscher, Ulrich, Kaspárková, Jana, Brabec, Viktor, Naegeli, Hanspeter

“…The multiprotein factor composed of XPA and replication protein A (RPA) is an essential subunit of the mammalian nucleotide excision repair system. Although…”
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DNA Modifications by a Novel Bifunctional Trinuclear Platinum Phase I Anticancer Agent by Brabec, Viktor, Kašpárková, Jana, Vrána, Oldøich, Nováková, Olga, Cox, John W, Qu, Yun, Farrell, Nicholas

“…The DNA-binding profile of a novel, trinuclear platinum Phase I clinical agent (BBR3464) is summarized. The structure of BBR3464 is best described as two…”
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Molecular aspects of resistance to antitumor platinum drugs by Brabec, Viktor, Kasparkova, Jana

“…The processes by which cells develop resistance to antitumor platinum drugs have been the subject of intense research because resistance is a major obstacle…”
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DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464. Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair by Kasparkova, Jana, Zehnulova, Jana, Farrell, Nicholas, Brabec, Viktor

“…The novel phase II antitumor polynuclear platinum drug BBR3464 ([(trans-PtCl(NH(3))(2))(2)(mu-trans-Pt(NH(3))(2)(NH(2)(CH(2))(6)NH(2))(2))](NO(3))(4)) forms…”
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Site-Specific d(GpG) Intrastrand Cross-Links Formed by Dinuclear Platinum Complexes. Bending and NMR Studies by Kašpárková, J, Mellish, K. J, Qu, Y, Brabec, V, Farrell, N

“…The novel platinum drugs [{trans-PtCl(NH3)2}2H2N(CH2)nNH2]2+ (1,1/t,t) are currently undergoing preclinical development. The bifunctional DNA binding of these…”
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Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complexElectronic supplementary information (ESI) available. See DOI: 10.1039/c7mt00052a by Hrabina, O, Kasparkova, J, Suchankova, T, Novohradsky, V, Guo, Z, Brabec, Viktor

“…The DNA interstrand cross-links of the antitumor drug {[ cis -Pt(NH 3 ) 2 Cl] 2 (4,4′-methylenedianiline)} 2+ ( 1 ) play a prevalent role in its antitumor…”
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DNA Binding Mode of the Cis and Trans Geometries of New Antitumor Nonclassical Platinum Complexes Containing Piperidine, Piperazine, or 4-Picoline Ligand in Cell-Free Media. Relations to Their Activity in Cancer Cell Lines by Kasparkova, Jana, Marini, Victoria, Najajreh, Yousef, Gibson, Dan, Brabec, Viktor

“…The global modification of mammalian and plasmid DNAs by novel platinum compounds, cis- or trans-[PtCl2(NH3)(Am)], where Am = NH3, nonplanar heterocycle…”
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Transplatin Is Cytotoxic When Photoactivated:  Enhanced Formation of DNA Cross-Links by Heringova, Pavla, Woods, Julie, Mackay, Fiona S, Kasparkova, Jana, Sadler, Peter J, Brabec, Viktor

“…It is well-known that although cisplatin, [cis-[PtCl2(NH3)2], is an anticancer drug, its isomer transplatin is not cytotoxic. Here we show that transplatin is…”
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Correlation between Cytotoxicity and DNA Binding of Polypyridyl Ruthenium Complexes by Novakova, Olga, Kasparkova, Jana, Vrana, Oldrich, van Vliet, Paul M, Reedijk, Jan, Brabec, Viktor

“…The cytotoxicity of chloropolypyridyl ruthenium complexes of structural formulas [Ru(terpy)-(bpy)Cl]Cl, cis-[Ru(bpy)2Cl2], and mer-[Ru(terpy)Cl3] (terpy =…”
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DNA–protein cross‐linking by trans‐[PtCl2(E‐iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes by Novakova, Olga, Kasparkova, Jana, Malina, Jaroslav, Natile, Giovanni, Brabec, Viktor

“…The structure–pharmacological activity relationships generally accepted for antitumor platinum compounds stressed the necessity for the cis‐[PtX2(amine)2]…”
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Effect of Geometric Isomerism in Dinuclear Platinum Antitumor Complexes on DNA Interstrand Cross-Linking by Kašpárková, Jana, Nováková, Olga, Vrána, Oldřich, Farrell, Nicholas, Brabec, Viktor

“…The requirement for novel platinum antitumor drugs led to the synthesis of dinuclear bisplatinum complexes. To understand the molecular mechanisms underlying…”
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DNA Binding by Antitumor trans-[PtCl2(NH3)(thiazole)]. Protein Recognition and Nucleotide Excision Repair of Monofunctional Adducts by Kasparkova, Jana, Novakova, Olga, Farrell, Nicholas, Brabec, Viktor

“…Antitumor effects of cis-diamminedichloroplatinum(II) (cisplatin) and the clinical inactivity of its trans isomer (transplatin) have been considered a paradigm…”
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Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding by Kasparkova, Jana, Vrana, Oldrich, Farrell, Nicholas, Brabec, Viktor

“…Polynuclear platinum compounds comprise a unique class of anticancer agents with chemical and biological properties different from mononuclear platinum drugs…”
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