Search Results - "Kasimova, Marina R"
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Preferential Interactions and the Effect of Protein PEGylation
Published in PloS one (31-07-2015)“…PEGylation is a strategy used by the pharmaceutical industry to prolong systemic circulation of protein drugs, whereas formulation excipients are used for…”
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The effect of protein PEGylation on physical stability in liquid formulation
Published in Journal of pharmaceutical sciences (01-10-2014)“…The presence of micron aggregates in protein formulations has recently attracted increased interest from regulatory authorities, industry, and academia because…”
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3
Elucidating the molecular mechanism of PAMAM–siRNA dendriplex self-assembly: Effect of dendrimer charge density
Published in International journal of pharmaceutics (20-09-2011)“…Dendrimers are attractive vehicles for nucleic acid delivery due to monodispersity and ease of chemical design. The purpose of this study was to elucidate the…”
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4
Molecular Characterization of the Interaction between siRNA and PAMAM G7 Dendrimers by SAXS, ITC, and Molecular Dynamics Simulations
Published in Biomacromolecules (13-12-2010)“…A prerequisite for the use of dendrimers as drug delivery vehicles is the detailed molecular understanding of the drug interaction. The purpose of this study…”
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5
On the Temperature Dependence of Complex Formation between Chitosan and Proteins
Published in Biomacromolecules (11-07-2011)“…Chitosan is a biocompatible easily degradable polysaccharide, which, because of its positive charge, is able to interact favorably with deprotonated carboxyl…”
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6
Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: Effects of hydrogen bonding and α-chirality in the β-peptoid residues
Published in Biochimica et biophysica acta (01-11-2012)“…Cell-penetrating peptides (CPPs) provide a promising approach for enhancing intracellular delivery of therapeutic biomacromolecules by increasing transport…”
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7
Thermal and acid denaturation of bovine lens α-crystallin
Published in Proteins, structure, function, and bioinformatics (01-06-2011)“…The chaperone‐like protein α‐crystallin is a ∼35 subunit hetero‐oligomer consisting of αA and αB subunits in a 3:1 molar ratio and has the function of…”
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Interaction of Peptidomimetics with Bilayer Membranes: Biophysical Characterization and Cellular Uptake
Published in Langmuir (20-03-2012)“…Enzymatically stable cell-penetrating α-peptide/β-peptoid peptidomimetics constitute promising drug delivery vehicles for the transport of therapeutic…”
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9
The Chaperone-like Protein α-Crystallin Dissociates Insulin Dimers and Hexamers
Published in Biochemistry (Easton) (06-10-2009)“…The protein α-crystallin, a member of the small heat shock protein family, has the ability to prevent aggregation of partially denatured proteins, an effect…”
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10
Free NADH Concentration Is Kept Constant in Plant Mitochondria under Different Metabolic Conditions
Published in The Plant cell (01-03-2006)“…The reduced coenzyme NADH plays a central role in mitochondrial respiratory metabolism. However, reports on the amount of free NADH in mitochondria are sparse…”
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Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems
Published in Biochimica et biophysica acta (01-09-2010)“…The modified ISCOMs, so-called Posintro™ nanoparticles, provide an opportunity for altering the surface charge of the particles, which influences their…”
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12
NMR Studies of the Backbone Flexibility and Structure of Human Growth Hormone: A Comparison of High and Low pH Conformations
Published in Journal of molecular biology (03-05-2002)“…15N NMR relaxation parameters and amide 1H/ 2H-exchange rates have been used to characterize the structural flexibility of human growth hormone (rhGH) at…”
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13
The conformational equilibrium of human growth hormone
Published in Journal of molecular biology (27-03-1998)“…The structural stability of recombinant human growth hormone (rhGH) has been studied by differential scanning calorimetry, circular dichroism and by following…”
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Thermodynamics of Interaction of the Fusion-Inhibiting Peptide Z-D-Phe-L-Phe-Gly with Dioleoylphosphatidylcholine Vesicles: Direct Calorimetric Determination
Published in Biochemistry (Easton) (25-07-1995)“…The binding of the fusion-inhibiting peptide Z-D-Phe-L-Phe-Gly to unilamellar lipid vesicles of dioleoylphosphatidylcholine (DOPC) was investigated by…”
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15
Thermal and acid denaturation of bovine lens [alpha]-crystallin
Published in Proteins, structure, function, and bioinformatics (01-06-2011)“…The chaperone-like protein [alpha]-crystallin is a 35 subunit hetero-oligomer consisting of [alpha]A and [alpha]B subunits in a 3:1 molar ratio and has the…”
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