Search Results - "Kashuba, Angela D M"

Clinical Pharmacokinetic, Pharmacodynamic and Drug-Interaction Profile of the Integrase Inhibitor Dolutegravir by Cottrell, Mackenzie L., Hadzic, Tanja, Kashuba, Angela D. M.

“…Dolutegravir is a second-generation integrase strand transfer inhibitor (INSTI) currently under review by the US Food and Drug Administration for marketing…”
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Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization by Bokhart, Mark T., Rosen, Elias, Thompson, Corbin, Sykes, Craig, Kashuba, Angela D. M., Muddiman, David C.

“…A quantitative mass spectrometry imaging (QMSI) technique using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is demonstrated…”
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Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection by Young, Isabella C., Massud, Ivana, Cottrell, Mackenzie L., Shrivastava, Roopali, Maturavongsadit, Panita, Prasher, Alka, Wong-Sam, Andres, Dinh, Chuong, Edwards, Tiancheng, Mrotz, Victoria, Mitchell, James, Seixas, Josilene Nascimento, Pallerla, Aryani, Thorson, Allison, Schauer, Amanda, Sykes, Craig, De la Cruz, Gabriela, Montgomery, Stephanie A., Kashuba, Angela D. M., Heneine, Walid, Dobard, Charles W., Kovarova, Martina, Garcia, J. Victor, Garcίa-Lerma, J. Gerardo, Benhabbour, S. Rahima

“…Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase adherence and maximize public health benefit. We report on an…”
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Mass spectrometry imaging of hair identifies daily maraviroc adherence in HPTN 069/ACTG A5305 by Rosen, Elias P, White, Nicole, Gilliland, Jr, William M, Gerona, Roy R, Gandhi, Monica, Amico, K Rivet, Mayer, Kenneth H, Gulick, Roy M, Kashuba, Angela D M

“…Objective measures of adherence for antiretrovirals used as pre-exposure prophylaxis (PrEP) are critical for improving preventative efficacy in both clinical…”
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Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection by Young, Isabella C., Massud, Ivana, Cottrell, Mackenzie L., Shrivastava, Roopali, Maturavongsadit, Panita, Prasher, Alka, Wong-Sam, Andres, Dinh, Chuong, Edwards, Tiancheng, Mrotz, Victoria, Mitchell, James, Seixas, Josilene Nascimento, Pallerla, Aryani, Thorson, Allison, Schauer, Amanda, Sykes, Craig, De la Cruz, Gabriela, Montgomery, Stephanie A., Kashuba, Angela D. M., Heneine, Walid, Dobard, Charles W., Kovarova, Martina, Garcia, J. Victor, Garcίa-Lerma, J. Gerardo, Benhabbour, S. Rahima

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Deep analysis of CD4 T cells in the rhesus CNS during SIV infection by Elizaldi, Sonny R, Verma, Anil, Ma, Zhong-Min, Ott, Sean, Rajasundaram, Dhivyaa, Hawes, Chase E, Lakshmanappa, Yashavanth Shaan, Cottrell, Mackenzie L, Kashuba, Angela D M, Ambrose, Zandrea, Lifson, Jeffrey D, Morrison, John H, Iyer, Smita S

“…Virologic suppression with antiretroviral therapy (ART) has significantly improved health outcomes for people living with HIV, yet challenges related to…”
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A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel by Schwartz, Jill L, Rountree, Wes, Kashuba, Angela D M, Brache, Vivian, Creinin, Mitchell D, Poindexter, Alfred, Kearney, Brian P

“…Tenofovir (TFV) gel is being evaluated as a microbicide with pericoital and daily regimens. To inhibit viral replication locally, an adequate concentration in…”
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Randomized Pharmacokinetic Crossover Study Comparing 2 Curcumin Preparations in Plasma and Rectal Tissue of Healthy Human Volunteers by Asher, Gary N., Xie, Ying, Moaddel, Ruin, Sanghvi, Mitesh, Dossou, Katina S. S., Kashuba, Angela D. M., Sandler, Robert S., Hawke, Roy L.

“…Curcumin is poorly absorbed, which is interest in new preparations. However, little is known about variations in its pharmacokinetics and tissue…”
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Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women by Karim, Salim S Abdool, Prof, Kashuba, Angela DM, PharmD, Werner, Lise, MSc, Karim, Quarraisha Abdool, Prof

“…[...] there is improved clarity about the threshold concentration of tenofovir that is likely to protect against HIV, the goal in future clinical trials of…”
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Mass spectrometry imaging reveals heterogeneous efavirenz distribution within putative HIV reservoirs by Thompson, Corbin G, Bokhart, Mark T, Sykes, Craig, Adamson, Lourdes, Fedoriw, Yuri, Luciw, Paul A, Muddiman, David C, Kashuba, Angela D M, Rosen, Elias P

“…Persistent HIV replication within active viral reservoirs may be caused by inadequate antiretroviral penetration. Here, we used mass spectrometry imaging with…”
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CCR5 inhibitor as novel acute graft versus host disease prophylaxis in children and young adults undergoing allogeneic stem cell transplant: results of the phase II study by Khandelwal, Pooja, Fukuda, Tsuyoshi, Teusink-Cross, Ashley, Kashuba, Angela D. M., Lane, Adam, Mehta, Parinda A., Marsh, Rebecca A., Jordan, Michael B., Grimley, Michael S., Myers, Kasiani C., Nelson, Adam S., El-Bietar, Javier, Chandra, Sharat, Bleesing, Jacob J., Krupski, Mary C., Davies, Stella M.

“…We report results of a phase II study of maraviroc to prevent acute graft versus host disease (GVHD) in children undergoing allogeneic hematopoietic stem cell…”
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Analysis of Antiretrovirals in Single Hair Strands for Evaluation of Drug Adherence with Infrared-Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging by Rosen, Elias P, Thompson, Corbin G, Bokhart, Mark T, Prince, Heather M. A, Sykes, Craig, Muddiman, David C, Kashuba, Angela D. M

“…Adherence to a drug regimen can be a strong predictor of health outcomes, and validated measures of adherence are necessary at all stages of therapy from drug…”
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Application of a Scavenger Receptor A1-Targeted Polymeric Prodrug Platform for Lymphatic Drug Delivery in HIV by Stevens, David M, Adiseshaiah, Pavan, Dasa, Siva S. K, Potter, Tim M, Skoczen, Sarah L, Snapp, Kelsie S, Cedrone, Edward, Patel, Nimit, Busman-Sahay, Kathleen, Rosen, Elias P, Sykes, Craig, Cottrell, Mackenzie, Dobrovolskaia, Marina A, Estes, Jacob D, Kashuba, Angela D. M, Stern, Stephan T

“…We have developed a macromolecular prodrug platform based on poly­(l-lysine succinylated) (PLS) that targets scavenger receptor A1 (SR-A1), a receptor…”
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Accuracy of Self-Report and Pill-Count Measures of Adherence in the FEM-PrEP Clinical Trial: Implications for Future HIV-Prevention Trials by Agot, Kawango, Taylor, Douglas, Corneli, Amy L., Wang, Meng, Ambia, Julie, Kashuba, Angela D. M., Parker, Caleb, Lemons, Ansley, Malahleha, Mookho, Lombaard, Johan, Van Damme, Lut

“…Oral emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) has been evaluated as pre-exposure prophylaxis (PrEP). We describe the accuracy of self-reported…”
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A spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host by Feder, Alison F, Kline, Christopher, Polacino, Patricia, Cottrell, Mackenzie, Kashuba, Angela D M, Keele, Brandon F, Hu, Shiu-Lok, Petrov, Dmitri A, Pennings, Pleuni S, Ambrose, Zandrea

“…The process by which drug-resistant HIV-1 arises and spreads spatially within an infected individual is poorly understood. Studies have found variable results…”
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Variability in drug metabolizing enzyme activity in HIV-infected patients by Jones, Amanda E, Brown, Kevin C, Werner, Rebecca E, Gotzkowsky, Karl, Gaedigk, Andrea, Blake, Mike, Hein, David W, van der Horst, Charles, Kashuba, Angela D. M

“…Aims To evaluate variability in cytochrome P450 (CYP) 1A2, CYP2D6, CYP3A, N-acetyltransferase 2 (NAT2), and xanthine oxidase (XO) activity in HIV-infected…”
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Population Pharmacokinetics of Metronidazole Evaluated Using Scavenged Samples from Preterm Infants by COHEN-WOLKOWIEZ, Michael, OUELLET, Daniele, KASHUBA, Angela D. M, BENJAMIN, Daniel K, BRIAN SMITH, P, JAMES, Laura P, ROSS, Ashley, SULLIVAN, Janice E, WALSH, Michele C, ZADELL, Arlene, NEWMAN, Nancy, WHITE, Nicole R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Maraviroc Concentrates in the Cervicovaginal Fluid and Vaginal Tissue of HIV-Negative Women by DUMOND, Julie B, PATTERSON, Kristine B, PECHA, Allison L, WERNER, Rebecca E, ANDREWS, Emma, DAMLE, Bharat, TRESSLER, Randall, WORSLEY, Jochen, KASHUBA, Angela D. M

“…To compare single- and multiple-dose maraviroc exposures in cervicovaginal fluid (CVF) and vaginal tissue (VT) with blood plasma (BP) and quantify maraviroc…”
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Sex hormones regulate tenofovir-diphosphate in female reproductive tract cells in culture by Shen, Zheng, Fahey, John V, Bodwell, Jack E, Rodriguez-Garcia, Marta, Kashuba, Angela D M, Wira, Charles R

“…The conflicting results of recent pre-exposure prophylaxis (PrEP) trials utilizing tenofovir (TFV) to prevent HIV infection in women led us to evaluate the…”
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Dose-Ranging Plasma and Genital Tissue Pharmacokinetics and Biodegradation of Ultra-Long-Acting Cabotegravir In Situ Forming Implant by Young, Isabella C, Thorson, Allison L, Shrivastava, Roopali, Sykes, Craig, Schauer, Amanda P, Cottrell, Mackenzie L, Kashuba, Angela D M, Benhabbour, Soumya Rahima

“…HIV continues to affect millions of men and women worldwide. The development of long-acting injectables for HIV prevention can overcome adherence challenges…”
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