Search Results - "Kashi Raj Bhattarai"

The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling by Bhattarai, Kashi Raj, Riaz, Thoufiqul Alam, Kim, Hyung-Ryong, Chae, Han-Jung

“…The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main functions include protein synthesis, proper protein folding, protein…”
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IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases by Junjappa, Raghu Patil, Patil, Prakash, Bhattarai, Kashi Raj, Kim, Hyung-Ryong, Chae, Han-Jung

“…Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane…”
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TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation by Kim, Hyun-Kyoung, Bhattarai, Kashi Raj, Junjappa, Raghu Patil, Ahn, Jin Hee, Pagire, Suvarna H., Yoo, Hyun Ju, Han, Jaeseok, Lee, Duckgue, Kim, Kyung-Woon, Kim, Hyung-Ryong, Chae, Han-Jung

“…Transmembrane B cell lymphoma 2-associated X protein inhibitor motif-containing (TMBIM) 6, a Ca 2+ channel-like protein, is highly up-regulated in several…”
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Author Correction: Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion by Lee, Hwa Young, Lee, Geum-Hwa, Bhattarai, Kashi Raj, Park, Byung-Hyun, Koo, Seung-Hoi, Kim, Hyung-Ryong, Chae, Han Jung

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Polyphenolic Extract of Euphorbia supina Attenuates Manganese-Induced Neurotoxicity by Enhancing Antioxidant Activity through Regulation of ER Stress and ER Stress-Mediated Apoptosis by Bahar, Entaz, Lee, Geum-Hwa, Bhattarai, Kashi Raj, Lee, Hwa-Young, Choi, Min-Kyung, Rashid, Harun-Or, Kim, Ji-Ye, Chae, Han-Jung, Yoon, Hyonok

“…Manganese (Mn) is an important trace element present in human body, which acts as an enzyme co-factor or activator in various metabolic reactions. While…”
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Ixeris dentata Extract Increases Salivary Secretion through the Regulation of Endoplasmic Reticulum Stress in a Diabetes-Induced Xerostomia Rat Model by Bhattarai, Kashi Raj, Lee, Hwa-Young, Kim, Seung-Hyun, Kim, Hyung-Ryong, Chae, Han-Jung

“…This study aimed to investigate the molecular mechanism of diabetes mellitus (DM)-induced dry mouth and an application of natural products from (IXD), a…”
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Chalcone suppresses tumor growth through NOX4-IRE1α sulfonation-RIDD-miR-23b axis by Kim, Hyun-Kyoung, Lee, Hwa-Young, Riaz, Thoufiqul Alam, Bhattarai, Kashi Raj, Chaudhary, Manoj, Ahn, Jin Hee, Jeong, Jieun, Kim, Hyung-Ryung, Chae, Han-Jung

“…Chalcone is a polyphenolic compound found abundantly in natural plant components. They have been acclaimed as potential antitumor compounds in multiple tumor…”
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TMBIM6 regulates redox-associated posttranslational modifications of IRE1α and ER stress response failure in aging mice and humans by Bhattarai, Kashi Raj, Kim, Hyun-Kyoung, Chaudhary, Manoj, Ur Rashid, Mohammad Mamun, Kim, Jisun, Kim, Hyung-Ryong, Chae, Han-Jung

“…Age-associated persistent ER stress is the result of declining chaperone systems of the ER that reduces cellular functions, induces apoptosis, and leads to…”
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Potential Application of Ixeris dentata in the Prevention and Treatment of Aging-Induced Dry Mouth by Bhattarai, Kashi Raj, Lee, Hwa-Young, Kim, Seung-Hyun, Park, Jong-Sug, Kim, Hyung-Ryong, Chae, Han-Jung

“…Dry mouth is a common complaint among the elderly population. The aim of this study was to investigate the effect of Ixeris dentata (IXD) extract on…”
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Bax Inhibitor-1 regulates hepatic lipid accumulation via ApoB secretion by Lee, Hwa Young, Lee, Geum-Hwa, Bhattarai, Kashi Raj, Park, Byung-Hyun, Koo, Seung-Hoi, Kim, Hyung-Ryong, Chae, Han Jung

“…In this study, we explored the effects of Bax Inhibitor-1 (BI-1) on ApoB aggregation in high-fat diet (HFD)-induced hepatic lipid accumulation. After 1 week on…”
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β-Cell protection and antidiabetic activities of Crassocephalum crepidioides (Asteraceae) Benth. S. Moore extract against alloxan-induced oxidative stress via regulation of apoptosis and reactive oxygen species (ROS) by Bahar, Entaz, Akter, Kazi-Marjahan, Lee, Geum-Hwa, Lee, Hwa-Young, Rashid, Harun-Or, Choi, Min-Kyung, Bhattarai, Kashi Raj, Hossain, Mir Mohammad Monir, Ara, Joushan, Mazumder, Kishor, Raihan, Obayed, Chae, Han-Jung, Yoon, Hyonok

“…Medicinal plants are becoming more popular in the treatment of various diseases because of the adverse effects of the current therapy, especially antioxidant…”
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Endoplasmic Reticulum (ER) Stress Response Failure in Diseases by Bhattarai, Kashi Raj, Chaudhary, Manoj, Kim, Hyung-Ryong, Chae, Han-Jung

“…Recent work provides evidence for the new terminology, ‘endoplasmic reticulum (ER) stress response or sensing failure’, in relation to metabolic disease. We…”
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TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium by Kim, Hyun-Kyoung, Lee, Geum-Hwa, Bhattarai, Kashi Raj, Lee, Myung-Shik, Back, Sung Hoon, Kim, Hyung-Ryong, Chae, Han-Jung

“…Lysosomal Ca 2+ contributes to macroautophagy/autophagy, an intracellular process for the degradation of cytoplasmic material and organelles in the lysosomes…”
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The imprint of salivary secretion in autoimmune disorders and related pathological conditions by Bhattarai, Kashi Raj, Junjappa, Raghupatil, Handigund, Mallikarjun, Kim, Hyung-Ryong, Chae, Han-Jung

“…Xerostomia is a state of oral dryness associated with salivary gland dysfunction and is induced by stress, radiation and chemical therapy, various systemic and…”
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Novel fluorescent C2-symmetric sequential on-off-on switch for Cu2+ and pyrophosphate and its application in monitoring of endogenous alkaline phosphatase activity by Pandith, Anup, Bhattarai, Kashi Raj, Guralamatta Siddappa, Ravi Kumara, Chae, Han-Jung, Seo, Young Jun

“…[Display omitted] •Novel and highly sensitive colorimetric and fluorimetric probe FLRHYDDFP designed and synthesized to identify the Cu2+ and PPi ions in…”
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Stepwise and site-selective enzymatic introduction of multiple functional groups to turn-on multiple fluorescence in long DNA strands by Nguyen, Van-Thang, Kumara, Guralamatta Siddappa Ravi, Bhattarai, Kashi Raj, Chae, Han–Jung, Seo, Young Jun

“…We have developed a stepwise and site-specific method, employing DNA polymerase, for the introduction of many functional groups into long DNA strands. With…”
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Epigenetic Fine Mapping and Functional Dissection of Inherited Non-Coding Variation Impacting the Pharmacogenomics of Acute Lymphoblastic Leukemia Treatment by Bhattarai, Kashi Raj, Barnett, Kelly R., Mobley, Robert J., Ferguson, Daniel C., Diedrich, Jonathan D., Bergeron, Brennan P., Yang, Wenjian, Crews, Kristine R., Stock, Wendy, Paietta, Elisabeth, Kornblau, Steven M., Inaba, Hiroto, Jeha, Sima, Pui, Ching-Hon, Cheng, Cheng, Relling, Mary V., Evans, William E., Yang, Jun J.J., Savic, Daniel

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Transmembrane BAX Inhibitor Motif-6 (TMBIM6) protects against cisplatin-induced testicular toxicity by Kim, Hyun-Kyoung, Yadav, Raj Kumar, Bhattarai, Kashi Raj, Jung, Han-Wool, Kim, Hyung-Ryong, Chae, Han-Jung

“…Abstract STUDY QUESTION Is the Transmembrane BAX Inhibitor Motif-6 (TMBIM6) involved in the molecular mechanism by which cisplatin causes reproductive…”
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Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment by Bhattarai, Kashi Raj, Mobley, Robert J., Barnett, Kelly R., Ferguson, Daniel C., Hansen, Baranda S., Diedrich, Jonathan D., Bergeron, Brennan P., Yoshimura, Satoshi, Yang, Wenjian, Crews, Kristine R., Manring, Christopher S., Jabbour, Elias, Paietta, Elisabeth, Litzow, Mark R., Kornblau, Steven M., Stock, Wendy, Inaba, Hiroto, Jeha, Sima, Pui, Ching-Hon, Cheng, Cheng, Pruett-Miller, Shondra M., Relling, Mary V., Yang, Jun J., Evans, William E., Savic, Daniel

“…Defining genetic factors impacting chemotherapy failure can help to better predict response and identify drug resistance mechanisms. However, there is limited…”
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PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD–RIG-I–NF-κB axis by Kim, Hyun-Kyoung, Lee, Geum-Hwa, Bhattarai, Kashi Raj, Junjappa, Raghu Patil, Lee, Hwa-Young, Handigund, Mallikarjun, Marahatta, Anu, Bhandary, Bidur, Baek, In-Hwan, Pyo, Jae Sung, Kim, Hye-Kyung, Chai, Ok Hee, Kim, Hyung-Ryong, Lee, Yong-Chul, Chae, Han-Jung

“…Hyperactivation of phosphoinositol 3-kinase (PI3K) has been suggested to be a potential mechanism for endoplasmic reticulum (ER) stress-enhanced airway…”
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