Search Results - "Kase, Eili T"

Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation by Feng, Yuan Z., Lund, Jenny, Li, Yuchuan, Knabenes, Irlin K., Bakke, Siril S., Kase, Eili T., Lee, Yun K., Kimmel, Alan R., Thoresen, G. Hege, Rustan, Arild Christian, Dalen, Knut Tomas

“…Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal…”
Get full text

Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid by Løvsletten, Nils G, Bakke, Siril S, Kase, Eili T, Ouwens, D Margriet, Thoresen, G Hege, Rustan, Arild C

“…It has previously been shown that pretreatment of differentiated human skeletal muscle cells (myotubes) with eicosapentaenoic acid (EPA) promoted increased…”
Get full text

Pancreatic Cancer Cell-Conditioned, Human-Derived Primary Myotubes Display Increased Leucine Turnover, Increased Lipid Accumulation, and Reduced Glucose Uptake by Krapf, Solveig A, Lund, Jenny, Saqib, Awais Ur Rehman, Bakke, Hege G, Rustan, Arild C, Thoresen, G. Hege, Kase, Eili T

“…Metabolic alterations occurring in cancer cells have been seen to also occur in other tissues than cancerous tissue. For instance, cachexia, peripheral insulin…”
Get full text

SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation by Krapf, Solveig A., Lund, Jenny, Bakke, Hege G., Nyman, Tuula A., Bartesaghi, Stefano, Peng, Xiao-Rong, Rustan, Arild C., Thoresen, G. Hege, Kase, Eili T.

“…Adipose tissue is one of the main regulative sites for energy metabolism. Excess lipid storage and expansion of white adipose tissue (WAT) is the primary…”
Get full text

Myotubes from severely obese type 2 diabetic subjects accumulate less lipids and show higher lipolytic rate than myotubes from severely obese non-diabetic subjects by Bakke, Siril S, Feng, Yuan Z, Nikolić, Natasa, Kase, Eili T, Moro, Cedric, Stensrud, Camilla, Damlien, Lisbeth, Ludahl, Marianne O, Sandbu, Rune, Solheim, Brita Marie, Rustan, Arild C, Hjelmesæth, Jøran, Thoresen, G Hege, Aas, Vigdis

“…About 80% of patients with type 2 diabetes are classified as overweight. However, only about 1/3 of severely obese subjects have type 2 diabetes. This…”
Get full text

Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects by Lund, Jenny, S Tangen, Daniel, Wiig, Håvard, Stadheim, Hans K, Helle, Siw A, B Birk, Jesper, Ingemann-Hansen, Thorsten, Rustan, Arild C, Thoresen, G Hege, Wojtaszewski, Jørgen F P, T Kase, Eili, Jensen, Jørgen

“…We hypothesised that skeletal muscles of healthy young people have a large variation in oxidative capacity and fibre-type composition, and aimed therefore to…”
Get full text

SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells by Lund, Jenny, Krapf, Solveig A., Sistek, Medina, Bakke, Hege G., Bartesaghi, Stefano, Peng, Xiao-Rong, Rustan, Arild C., Thoresen, G. Hege, Kase, Eili T.

“…Sentrin-specific protease (SENP) 2 has been suggested as a possible novel drug target for the treatment of obesity and type 2 diabetes mellitus after…”
Get full text

Skeletal Muscle Lipid Accumulation in Type 2 Diabetes May Involve the Liver X Receptor Pathway by KASE, Eili T, WENSAAS, Andreas J, AAS, Vigdis, HØJLUND, Kurt, LEVIN, Klaus, HEGE THORESEN, G, BECK-NIELSEN, Henning, RUSTAN, Arild C, GASTER, Michael

“…Skeletal Muscle Lipid Accumulation in Type 2 Diabetes May Involve the Liver X Receptor Pathway Eili T. Kase 1 , Andreas J. Wensaas 1 , Vigdis Aas 1 , Kurt…”
Get full text

Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells by Kong, Xiang Y, Nesset, Cecilie Kasi, Damme, Markus, Løberg, Else-Marit, Lübke, Torben, Mæhlen, Jan, Andersson, Kristin B, Lorenzo, Petra I, Roos, Norbert, Thoresen, G Hege, Rustan, Arild C, Kase, Eili T, Eskild, Winnie

“…Human kidney predominant protein, NCU-G1, is a highly conserved protein with an unknown biological function. Initially described as a nuclear protein, it was…”
Get full text

Time-dependent reduction in oxidative capacity among cultured myotubes from spinal cord injured individuals by Stevanovic, Stanislava, Dalmao-Fernandez, Andrea, Mohamed, Derya, Nyman, Tuula A, Kostovski, Emil, Iversen, Per Ole, Savikj, Mladen, Nikolic, Natasa, Rustan, Arild C, Thoresen, G Hege, Kase, Eili T

“…Skeletal muscle adapts in reaction to contractile activity to efficiently utilize energy substrates, primarily glucose and free fatty acids (FA). Inactivity…”
Get full text

Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism by Løvsletten, Nils G., Vu, Helene, Skagen, Christine, Lund, Jenny, Kase, Eili T., Thoresen, G. Hege, Zammit, Victor A., Rustan, Arild C.

“…Diacylglycerol acyltransferases (DGAT) 1 and 2 catalyse the final step in triacylglycerol (TAG) synthesis, the esterification of fatty acyl-CoA to…”
Get full text

Higher lipid turnover and oxidation in cultured human myotubes from athletic versus sedentary young male subjects by Lund, Jenny, Helle, Siw A., Li, Yuchuan, Løvsletten, Nils G., Stadheim, Hans K., Jensen, Jørgen, Kase, Eili T., Thoresen, G. Hege, Rustan, Arild C.

“…In this study we compared fatty acid (FA) metabolism in myotubes established from athletic and sedentary young subjects. Six healthy sedentary (maximal oxygen…”
Get full text

Pancreatic cancer cells show lower oleic acid oxidation and their conditioned medium inhibits oleic acid oxidation in human myotubes by Krapf, Solveig A., Lund, Jenny, Lundkvist, Malin, Dale, Marianne G., Nyman, Tuula A., Thoresen, G. Hege, Kase, Eili T.

“…/Objectives: We aimed to metabolically compare healthy primary human pancreatic epithelial cells (hPEC) to a pancreatic cancer cell line (PANC-1) and explore…”
Get full text

Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise by Feng, Yuan Z, Nikolić, Nataša, Bakke, Siril S, Kase, Eili T, Guderud, Kari, Hjelmesæth, Jøran, Aas, Vigdis, Rustan, Arild C, Thoresen, G Hege

“…Exercise improves insulin sensitivity and oxidative capacity in skeletal muscles. However, the effect of exercise on substrate oxidation is less clear in obese…”
Get more information

Primary defects in lipolysis and insulin action in skeletal muscle cells from type 2 diabetic individuals by Kase, Eili T., Feng, Yuan Z., Badin, Pierre-Marie, Bakke, Siril S., Laurens, Claire, Coue, Marine, Langin, Dominique, Gaster, Michael, Thoresen, G. Hege, Rustan, Arild C., Moro, Cedric

“…A decrease in skeletal muscle lipolysis and hormone sensitive-lipase (HSL) expression has been linked to insulin resistance in obesity. The purpose of this…”
Get full text

Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism by Lund, Jenny, Rustan, Arild C, Løvsletten, Nils G, Mudry, Jonathan M, Langleite, Torgrim M, Feng, Yuan Z, Stensrud, Camilla, Brubak, Mari G, Drevon, Christian A, Birkeland, Kåre I, Kolnes, Kristoffer J, Johansen, Egil I, Tangen, Daniel S, Stadheim, Hans K, Gulseth, Hanne L, Krook, Anna, Kase, Eili T, Jensen, Jørgen, Thoresen, G Hege

“…Physical activity has preventive as well as therapeutic benefits for overweight subjects. In this study we aimed to examine effects of in vivo exercise on in…”
Get full text

LXR antagonists induce ABCD2 expression by Gondcaille, Catherine, Genin, Emmanuelle C., Lopez, Tatiana E., Dias, Alexandre M.M., Geillon, Flore, Andreoletti, Pierre, Cherkaoui-Malki, Mustapha, Nury, Thomas, Lizard, Gérard, Weinhofer, Isabelle, Berger, Johannes, Kase, Eili T., Trompier, Doriane, Savary, Stéphane

“…X-linked adrenoleukodystrophy (X-ALD) is a rare neurodegenerative disorder characterized by the accumulation of very-long-chain fatty acids resulting from a…”
Get full text

Increased glucose utilization and decreased fatty acid metabolism in myotubes from Glmp(gt/gt) mice by Kong, Xiang Yi, Feng, Yuan Zeng, Eftestøl, Einar, Kase, Eili T, Haugum, Hanne, Eskild, Winnie, Rustan, Arild C, Thoresen, G Hege

“…Glycosylated lysosomal membrane protein (GLMP) has been reported to enhance the expression from a peroxisome proliferator-activated receptor alpha (PPARα)…”
Get full text

PPARδ activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference by Feng, Yuan Z., Nikoli, Nataša, Bakke, Siril S., Boekschoten, Mark V., Kersten, Sander, Kase, Eili T., Rustan, Arild C., Thoresen, G. Hege

“…Abstract The role of peroxisome proliferator-activated receptor δ (PPARδ) activation on global gene expression and mitochondrial fuel utilization were…”
Get full text

Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol by Åstrand, O. Alexander H., Sandberg, Marcel, Sylte, Ingebrigt, Görbitz, Carl Henrik, Thoresen, G. Hege, Kase, Eili T., Rongved, Pål

“…The generic, synthetic oxysterol 22(S)-hydroxycholesterol (22SHC) has shown antagonistic effects towards liver X receptor (LXR) in vitro and promising effects…”
Get full text