Search Results - "Kasap, Merve"

Clozapine, nimodipine and endosulfan differentially suppress behavioral defects caused by gain-of-function mutations in a two-pore domain K+ channel (UNC-58) by Kasap, Merve, Dwyer, Donard S.

“…•Directed screening of drugs to counteract locomotion deficits revealed positive hits.•Clozapine, nimodipine and loxapine effectively modulated K2P-induced…”
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Na+ leak-current channel (NALCN) at the junction of motor and neuropsychiatric symptoms in Parkinson’s disease by Kasap, Merve, Dwyer, Donard S.

“…Parkinson’s disease (PD) is a debilitating movement disorder often accompanied by neuropsychiatric symptoms that stem from the loss of dopaminergic function in…”
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Surprising conservation of schizophrenia risk genes in lower organisms reflects their essential function and the evolution of genetic liability by Kasap, Merve, Rajani, Vivek, Rajani, Jackie, Dwyer, Donard S.

“…Schizophrenia is a devastating psychiatric illness that affects approximately 1% of the population. Genetic variation in multiple genes causes elevated risk…”
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Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins by Afuwape, Olusoji A T, Chanaday, Natali L, Kasap, Merve, Monteggia, Lisa M, Kavalali, Ege T

“…Dynamins are GTPases required for pinching vesicles off the plasma membrane once a critical curvature is reached during endocytosis. Here, we probed dynamin…”
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Opioid system mediated anti-nociceptive effect of agomelatine in mice by Kasap, Merve, Can, Özgür Devrim

“…This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as…”
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How Variation in Risk Allele Output and Gene Interactions Shape the Genetic Architecture of Schizophrenia by Kasap, Merve, Dwyer, Donard S.

“…Schizophrenia is a highly heritable polygenic psychiatric disorder. Characterization of its genetic architecture may lead to a better understanding of the…”
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Akinesia and freezing caused by Na super(+) leak-current channel (NALCN) deficiency corrected by pharmacological inhibition of K super(+) channels and gap junctions by Kasap, Merve, Bonnett, Kendra, Aamodt, Eric J, Dwyer, Donard S

“…The Na super(+) leak-current channel (NALCN) regulates locomotion, respiration, and intellectual development. Previous work highlighted striking similarities…”
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Akinesia and freezing caused by Na+ leak‐current channel (NALCN) deficiency corrected by pharmacological inhibition of K+ channels and gap junctions by Kasap, Merve, Bonnett, Kendra, Aamodt, Eric J., Dwyer, Donard S.

“…The Na+ leak‐current channel (NALCN) regulates locomotion, respiration, and intellectual development. Previous work highlighted striking similarities between…”
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Novel pharmacological modulation of dystonic phenotypes caused by a gain-of-function mutation in the Na+ leak-current channel by Kasap, Merve, Aamodt, Eric J., Sagrera, Caroline E., Dwyer, Donard S.

“…The Na+ leak-current channel (NALCN) regulates the resting membrane potential in excitable cells, thus determining the likelihood of depolarization in response…”
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The Role of Neuronal Leak Channels in the Regulation of Movement by Kasap, Merve

“…The sodium and potassium leak ion channels establish the resting membrane potential in neurons. The two pore-domain potassium channels (K2Ps) are…”
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Identifying the Putative G Protein Coupled Receptor/s Candidates of Cocaine and Amphetamine Regulated Transcript (CART) Peptide by Kasap, Merve

“…Cocaine and amphetamine regulated transcript (CART) peptides are neurotransmitters and endocrine factors in the nervous system and periphery. CARTPT codes for…”
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Rutinin Analjezik Etki Mekanizmasının Araştırılması by Kasap, Merve Fatma

“…Rutin analjezik ve antiinflamatuvar etkinliği olduğu bilinen ve pek çok tıbbi bitki içerisinde yer alan bir flavonoiddir. Bu tez çalışmasında rutinin analjezik…”
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Agomelatin'In Antinosiseptif Etkinliğinin Deneysel Akut Ağrı Modelleri Ile Araştırılması by Kasap, Merve

“…Agomelatin, melatoninin MT? ve MT? reseptörlerine agonist ve serotoninin 5-HT?c reseptörlerine antagonist etki gösteren, kendine has etki mekanizmasına sahip…”
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