Search Results - "Kas, M J"

Social isolation stress reduces hippocampal long-term potentiation: Effect of animal strain and involvement of glucocorticoid receptors by Kamal, A, Ramakers, G.M.J, Altinbilek, B, Kas, M.J.H

“…Highlights • Long-term potentiation was measured in hippocampal slices from two mouse strains. • The level of long-term potentiation is different in one strain…”
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The MC4 receptor and control of appetite by Adan, R A H, Tiesjema, B, Hillebrand, J J G, Fleur, S E, Kas, M J H, Krom, M

“…Mutations in the human melanocortin (MC)4 receptor have been associated with obesity, which underscores the relevance of this receptor as a drug target to…”
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Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men by KAS, M. J. H, FERNANDES, C, SCHALKWYK, L. C, COLLIER, D. A

“…Family and twin studies have revealed that genetic factors play a major role in psychiatric disorders, however, attempts to find susceptibility genes for these…”
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The use of mouse models to unravel genetic architecture of physical activity: a review by Kostrzewa, E., Kas, M. J.

“…The discovery of genetic variants that underlie a complex phenotype is challenging. One possible approach to facilitate this endeavor is to identify…”
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NPY receptor subtype specification for behavioral adaptive strategies during limited food access by Pjetri, E., Adan, R. A., Herzog, H., de Haas, R., Oppelaar, H., Spierenburg, H. A., Olivier, B., Kas, M. J.

“…The neuropeptide Y (NPY) system in the brain regulates a wide variety of behavioral, metabolic and hormonal homeostatic processes required for energy balance…”
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Cross‐species genetics converge to TLL2 for mouse avoidance behavior and human bipolar disorder by de Mooij‐van Malsen, J.G., van Lith, H.A., Laarakker, M.C., Brandys, M.K., Oppelaar, H., Collier, D.A., Olivier, B., Breen, G., Kas, M.J.

“…Interspecies genetic analysis of neurobehavioral traits is critical for identifying neurobiological mechanisms underlying psychiatric disorders, and for…”
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Agouti-related protein prevents self-starvation by KAS, M. J. H, VAN DIJK, G, SCHEURINK, A. J. W, ADAN, R. A. H

“…Food restriction leads to a paradoxical increase in physical activity and further suppression of food intake, such as observed in anorexia nervosa.(1,2) To…”
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Leptin's effect on hyperactivity: Potential downstream effector mechanisms by Hillebrand, J.J.G, Kas, M.J.H, van Elburg, A.A, Hoek, H.W, Adan, R.A.H

“…Abstract Up to 80% of patients with Anorexia Nervosa (AN) demonstrate hyperactivity. Hyperactivity counteracts weight gain during treatment and is associated…”
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Evidence for Epigenetic Interactions for Loci on Mouse Chromosome 1 Regulating Open Field Activity by de Mooij-van Malsen, J. G., van Lith, H. A., Oppelaar, H., Olivier, B., Kas, M. J. H.

“…The expression of motor activity levels in response to novel situations is under complex genetic and environmental control. Several genetic loci have been…”
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Variations in ventral root axon morphology and locomotor behavior components across different inbred strains of mice by de Mooij-van Malsen, J.G, Yu, K.L, Veldman, H, Oppelaar, H, van den Berg, L.H, Olivier, B, Kas, M.J.H

“…Abstract Locomotion is a complex behavior affected by many different brain- and spinal cord systems, as well as by variations in the peripheral nervous system…”
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Theory of Mind and social functioning among neuropsychiatric disorders: A transdiagnostic study by Braak, S., Su, T., Krudop, W., Pijnenburg, Y.A.L., Reus, L.M., van der Wee, N., Bilderbeck, A.C., Dawson, G.R., van Rossum, I. Winter, Campos, A. Vieira, Arango, C., Saris, I.M.J., Kas, M.J., Penninx, B.W.J.H.

“…•Theory of Mind deficits are present in schizophrenia and Alzheimer's disease patients.•Theory of Mind deficits are transdiagnostically associated with social…”
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High‐resolution genetic mapping of mammalian motor activity levels in mice by Kas, M. J. H., De Mooij‐van Malsen, J. G., De Krom, M., Van Gassen, K. L. I., Van Lith, H. A., Olivier, B., Oppelaar, H., Hendriks, J., De Wit, M., Groot Koerkamp, M. J. A., Holstege, F. C. P., Van Oost, B. A., De Graan, P. N. E.

“…The generation of motor activity levels is under tight neural control to execute essential behaviors, such as movement toward food or for social interaction…”
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Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility by Hessel, E. V. S., Van Gassen, K. L. I., Wolterink‐Donselaar, I. G., Stienen, P. J., Fernandes, C., Brakkee, J. H., Kas, M. J. H., De Graan, P. N. E.

“…Febrile seizures (FS) are the most common seizure type in children and recurrent FS are a risk factor for developing temporal lobe epilepsy. Although the…”
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Novel approach to the behavioural characterization of inbred mice: automated home cage observations by De Visser, L., Van Den Bos, R., Kuurman, W. W., Kas, M. J. H., Spruijt, B. M.

“…Here we present a newly developed tool for continuous recordings and analysis of novelty‐induced and baseline behaviour of mice in a home cage‐like…”
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A candidate syntenic genetic locus is associated with voluntary exercise levels in mice and humans by Kostrzewa, E, Brandys, M K, van Lith, H A, Kas, M J H

“…Individual levels of physical activity, and especially of voluntary physical exercise, highly contribute to the susceptibility for developing metabolic,…”
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Dopaminergic and brain‐derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule by Gelegen, C., Van Den Heuvel, J., Collier, D. A., Campbell, I. C., Oppelaar, H., Hessel, E., Kas, M. J. H.

“…Increased physical activity and decreased motivation to eat are common features in anorexia nervosa. We investigated the development of these features and the…”
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Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule by Gelegen, C, Pjetri, E, Campbell, I.C, Collier, D.A, Oppelaar, H, Kas, M.J.H

“…Abstract Excessive physical activity plays an important role in the progression of anorexia nervosa (AN) by accelerating weight loss during dietary…”
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In search for significant cognitive features in Klinefelter syndrome through cross‐species comparison of a supernumerary X chromosome by Bruining, H., Swaab, H., de Sonneville, L. M. J., van Rijn, S., van Engeland, H., Kas, M. J. H.

“…The behavioral characterization of animals that carry genetic disorder abnormalities in a controlled genetic and environmental background may be used to…”
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The impact of hyperactivity and leptin on recovery from anorexia nervosa by van Elburg, A A, Kas, M J H, Hillebrand, J J G, Eijkemans, R J C, van Engeland, H

“…In anorexia nervosa (AN), hyperactivity is observed in about 80% of patients and has been associated with low leptin levels in the acute stage of AN and in…”
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Neurobiology driving hyperactivity in activity-based anorexia by Adan, R A H, Hillebrand, J J G, Danner, U N, Cardona Cano, S, Kas, M J H, Verhagen, L A W

“…Hyperactivity in anorexia nervosa is difficult to control and negatively impacts outcome. Hyperactivity is a key driving force to starvation in an animal model…”
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