Search Results - "Karvonen, Matti K."

Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial by Ranieri, V. Marco, Pettilä, Ville, Karvonen, Matti K, Jalkanen, Juho, Nightingale, Peter, Brealey, David, Mancebo, Jordi, Ferrer, Ricard, Mercat, Alain, Patroniti, Nicolò, Quintel, Michael, Vincent, Jean-Louis, Okkonen, Marjatta, Meziani, Ferhat, Bellani, Giacomo, MacCallum, Niall, Creteur, Jacques, Kluge, Stefan, Artigas-Raventos, Antonio, Maksimow, Mikael, Piippo, Ilse, Elima, Kati, Jalkanen, Sirpa, Jalkanen, Markku, Bellingan, Geoff

“…IMPORTANCE: Acute respiratory distress syndrome (ARDS) is associated with high mortality. Interferon (IFN) β-1a may prevent the underlying event of vascular…”
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Intravenous Interferon β-1a for Severe ARDS—Reply by Bellingan, Geoff, Ranieri, V. Marco, Karvonen, Matti K

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Nonclinical Characterization of Bexmarilimab, a Clever-1-Targeting Antibody for Supporting Immune Defense Against Cancers by Hollmén, Maija, Maksimow, Mikael, Rannikko, Jenna H, Karvonen, Matti K, Vainio, Marita, Jalkanen, Sirpa, Jalkanen, Markku, Mandelin, Jami

“…Common lymphatic endothelial and vascular endothelial receptor-1 (Clever-1) is a multifunctional type-1 transmembrane protein that plays an important role in…”
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Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial by Virtakoivu, Reetta, Rannikko, Jenna H, Viitala, Miro, Vaura, Felix, Takeda, Akira, Lönnberg, Tapio, Koivunen, Jussi, Jaakkola, Panu, Pasanen, Annika, Shetty, Shishir, de Jonge, Maja J A, Robbrecht, Debbie, Ma, Yuk Ting, Skyttä, Tanja, Minchom, Anna, Jalkanen, Sirpa, Karvonen, Matti K, Mandelin, Jami, Bono, Petri, Hollmén, Maija

“…Macrophages are critical in driving an immunosuppressive tumor microenvironment that counteracts the efficacy of T-cell-targeting therapies. Thus, agents able…”
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Leucine 7 to Proline 7 Polymorphism in the Preproneuropeptide Y Is Associated With Proteinuria, Coronary Heart Disease, and Glycemic Control in Type 1 Diabetic Patients by PETTERSSON-FERNHOLM, Kim, KARVONEN, Matti K, KALLIO, Jaana, FORSBLOM, Carol M, KOULU, Markku, PESONEN, Ullamari, FAGERUDD, Johan A, GROOP, Per-Henrik

“…Leucine 7 to Proline 7 Polymorphism in the Preproneuropeptide Y Is Associated With Proteinuria, Coronary Heart Disease, and Glycemic Control in Type 1 Diabetic…”
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Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics by Saito, Takuya, Lachman, Herbert M., Diaz, Libna, Hallikainen, Tero, Kauhanen, Jussi, Salonen, Jukka T., Ryynänen, Olli-Pekka, Karvonen, Matti K., Syvälahti, Erkka, Pohjalainen, Tiina, Hietala, Jarmo, Tiihonen, Jari

“…Alterations in monoamine oxidase A (MAOA) expression and enzyme activity may be associated with alcoholism and impulsive behavior. Therefore, functional…”
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Induction of CD73 prevents death after emergency open aortic surgery for a ruptured abdominal aortic aneurysm: a randomized, double-blind, placebo-controlled study by Hakovirta, Harri, Jalkanen, Juho, Saimanen, Eija, Kukkonen, Tiia, Romsi, Pekka, Suominen, Velipekka, Vikatmaa, Leena, Valtonen, Mika, Karvonen, Matti K., Venermo, Maarit

“…Mortality remains high after emergency open surgery for a ruptured abdominal aortic aneurysm (RAAA). The aim of the present study was to assess, if intravenous…”
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Seizure control in Unverricht-Lundborg disease: a single-centre study by Roivainen, Reina, Karvonen, Matti K., Puumala, Tarja

“…New antiepileptic drug (AED) options for generalised seizure types have been adopted for use as treatment for Unverricht‐Lundborg disease. Whether this has led…”
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Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors: The phase I/II first-in-human MATINS trial by Rannikko, Jenna H, Verlingue, Loic, de Miguel, Maria, Pasanen, Annika, Robbrecht, Debbie, Skytta, Tanja, Iivanainen, Sanna, Shetty, Shishir, Ma, Yuk Ting, Graham, Donna M, Arora, Sukeshi Patel, Jaakkola, Panu, Yap, Christina, Xiang, Yujuan, Mandelin, Jami, Karvonen, Matti K, Jalkanen, Juho, Karaman, Sinem, Koivunen, Jussi P, Minchom, Anna, Hollmén, Maija, Bono, Petri

“…Macrophage Clever-1 contributes to impaired antigen presentation and suppression of anti-tumor immunity. This first-in-human trial investigates the safety and…”
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Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels by Koulu, Markku, Karvonen, Matti K, Pesonen, Ullamari, Niskanen, Leo, Laakso, Markku, Rissanen, Aila, Dekker, Jacqueline M, Hart, Leen M ´t, Valve, Raisa, Uusitupa, Matti I.J

“…High serum levels of total and LDL cholesterol are important risk factors in the development of atherosclerotic coronary artery disease. Cholesterol metabolism…”
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Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19) by Paimela, Tuomas, Hyttinen, Juha M.T., Viiri, Johanna, Ryhänen, Tuomas, Karvonen, Matti K., Unkila, Mikko, Uusitalo, Hannu, Salminen, Antero, Kaarniranta, Kai

“…Since estrogen and selective estrogen receptor modulators can inhibit inflammatory responses, we studied the regulatory role of several selective estrogen…”
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An insertion/deletion polymorphism in the α2b-adrenergic receptor gene is a novel genetic risk factor for acute coronary events by Snapir, Amir, Heinonen, Paula, Tuomainen, Tomi-Pekka, Alhopuro, Pia, Karvonen, Matti K, Lakka, Timo A, Nyyssönen, Kristiina, Salonen, Riitta, Kauhanen, Jussi, Valkonen, Veli-Pekka, Pesonen, Ullamari, Koulu, Markku, Scheinin, Mika, Salonen, Jukka T

“…OBJECTIVES Our aim was to study whether an insertion/deletion (I/D) polymorphism in the α2B-adrenoceptor gene is associated with the risk for cardiovascular…”
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Nutrient Intake, Weight, and Leu7Pro Polymorphism in Prepro-Neuropeptide Y in Children by Karvonen, Matti K., Ruottinen, Soile, Koulu, Markku, Pesonen, Ullamari, Niinikoski, Harri, Rask-Nissilä, Leena, Simell, Olli, Rönnemaa, Tapani

“…Context: The important role of neuropeptide Y (NPY) in the regulation of food intake and energy balance has been firmly documented in rodents, but human data…”
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Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men by Karvonen, Matti K, Valkonen, Veli-Pekka, Lakka, Timo A, Salonen, Riitta, Koulu, Markku, Pesonen, Ullamari, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Nyyssönen, Kristiina, Lakka, Hanna-Maaria, Uusitupa, Matti I.J, Salonen, Jukka T

“…A rather common leucine7-to-proline7 (Leu7Pro) polymorphism in the preproneuropeptide Y (prepro-NPY) gene signal peptide may be important in blood pressure…”
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Changes in Diurnal Sympathoadrenal Balance and Pituitary Hormone Secretion in Subjects with Leu7Pro Polymorphism in the Prepro-Neuropeptide Y by Kallio, Jaana, Pesonen, Ullamari, Jaakkola, Ulriikka, Karvonen, Matti K., Helenius, Hans, Koulu, Markku

“…Neuropeptide Y (NPY) is an important neurotransmitter in the central and peripheral nervous systems. It has a regulatory role in cardiovascular and metabolic…”
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Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization by Koulu, Markku, Movafagh, Sharareh, Tuohimaa, Jukka, Jaakkola, Ulriikka, Kallio, Jaana, Pesonen, Ullamari, Geng, Yixun, Karvonen, Matti K, Vainio-Jylhä, Elina, Pöllönen, Matti, Kaipio-Salmi, Katja, Seppälä, Helena, Lee, Edward W, Higgins, Rosemary D, Zukowska, Zofia

“…Neuropeptide Y is a sympathetic neurotransmitter, a potent endothelium-derived angiogenic factor and a vascular mitogen. We have studied the role of the…”
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Cloning, characterisation and identification of several polymorphisms in the promoter region of the human α2B-adrenergic receptor gene by CAYLA, Cécile, HEINONEN, Paula, VIIKARI, Liisa, SCHAAK, Stéphane, SNAPIR, Amir, BOULOUMIE, Anne, KARVONEN, Matti K, PESONEN, Ullamari, SCHEININ, Mika, PARIS, Hervé

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Shunt catheter migration into pulmonary arteries by Korja, Miikka, Karvonen, Matti K, Haapanen, Arto, Marttila, Reijo J

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Enhanced endothelium-dependent vasodilation in subjects with Proline7 substitution in the signal peptide of neuropeptide Y by Järvisalo, Mikko J, Jartti, Laura, Karvonen, Matti K, Pesonen, Ullamari, Koulu, Markku, Marniemi, Jukka, Hammar, Niklas, Kaprio, Jaakko, Paakkunainen, Ulla, Simell, Olli, Raitakari, Olli T, Rönnemaa, Tapani

“…Neuropeptide Y (NPY) is a molecule that may have both vasoconstrictive and vasodilatory actions. A common polymorphism in the human NPY gene that results in…”
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Identification of New Sequence Variants in the Leptin Gene by Karvonen, Matti K, Pesonen, Ullamari, Heinonen, Paula, Laakso, Markku, Rissanen, Aila, Naukkarinen, Hannu, Valve, Raisa, Uusitupa, Matti I. J, Koulu, Markku

“…The leptin gene (LEP) has been linked to extreme obesity. However, no common obesity-related gene variants have been found to exist in the LEP. The present…”
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