Search Results - "Karunasinghe, Rashika N"

Hyaluronan synthesis by developing cortical neurons in vitro by Fowke, Tania M., Karunasinghe, Rashika N., Bai, Ji-Zhong, Jordan, Shawn, Gunn, Alistair J., Dean, Justin M.

“…Hyaluronan is a linear glycosaminoglycan that forms the backbone of perineuronal nets around neurons in the cerebral cortex. However, it remains controversial…”
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Connexin Hemichannel Mimetic Peptide Attenuates Cortical Interneuron Loss and Perineuronal Net Disruption Following Cerebral Ischemia in Near-Term Fetal Sheep by Yang, Panzao, Davidson, Joanne O, Fowke, Tania M, Galinsky, Robert, Wassink, Guido, Karunasinghe, Rashika N, Prasad, Jaya D, Ranasinghe, Sumudu, Green, Colin R, Bennet, Laura, Gunn, Alistair J, Dean, Justin M

“…Perinatal hypoxia-ischemia is associated with disruption of cortical gamma-aminobutyric acid (GABA)ergic interneurons and their surrounding perineuronal nets,…”
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Blockade of connexin hemichannels with tonabersat protects against mild hypoxic ischemic brain injury in neonatal rats by McDouall, Alice, Wassink, Guido, Ranasinghe, Sumudu, Zhou, Kelly Q, Karunasinghe, Rashika N, Dean, Justin M, Davidson, Joanne O

“…There is growing evidence that infants with mild hypoxic-ischemic (HI) encephalopathy have increased risk of brain injury and adverse neurodevelopmental…”
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Oxygen and glucose deprivation (OGD)-induced spreading depression in the Substantia Nigra by Karunasinghe, Rashika N, Lipski, Janusz

“…Abstract Spreading depression (SD) is a profound depolarization of neurons and glia that propagates in a wave-like manner across susceptible brain regions, and…”
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Acute sensitivity of astrocytes in the Substantia Nigra to oxygen and glucose deprivation (OGD) compared with hippocampal astrocytes in brain slices by Karunasinghe, Rashika N., Dean, Justin M., Lipski, Janusz

“…•Astrocytic responses to oxygen and glucose deprivation (OGD) were investigated in brain slice, an in vitro ischemia model.•OGD depolarized astrocytes in the…”
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Dopamine Dysregulation and Altered Responses to Drugs Affecting Dopaminergic Transmission in a New Dopamine Transporter Knockout (DAT-KO) Rat Model by Lloyd, Jordan T., Yee, Andrew G., Kalligappa, Prasanna K., Jabed, Anower, Cheung, Pang Y., Todd, Kathryn L., Karunasinghe, Rashika N., Vlajkovic, Srdjan M., Freestone, Peter S., Lipski, Janusz

“…•Our genetic model extends the range of animals for dopamine dysregulation studies.•Voltammetry was used to measure dopamine both in the striatum and…”
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Loss of interneurons and disruption of perineuronal nets in the cerebral cortex following hypoxia-ischaemia in near-term fetal sheep by Fowke, Tania M., Galinsky, Robert, Davidson, Joanne O., Wassink, Guido, Karunasinghe, Rashika N., Prasad, Jaya D., Bennet, Laura, Gunn, Alistair J., Dean, Justin M.

“…Hypoxia-ischaemia (HI) in term infants is a common cause of brain injury and neurodevelopmental impairment. Development of gamma-aminobutyric acid (GABA)ergic…”
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Differential spread of anoxic depolarization contributes to the pattern of neuronal injury after oxygen and glucose deprivation (OGD) in the Substantia Nigra in rat brain slices by Karunasinghe, Rashika N, Grey, Angus C, Telang, Ravindra, Vlajkovic, Srdjan M, Lipski, Janusz

“…Highlights • Oxygen-glucose deprivation (OGD) mimicks many features of brain ischemia. • OGD evokes differential responses in the Substantia Nigra in brain…”
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