Search Results - "Karunaratne, Angelo"

Nano-scale mechanisms explain the stiffening and strengthening of ligament tissue with increasing strain rate by Karunaratne, Angelo, Li, Simin, Bull, Anthony M. J.

“…Ligament failure is a major societal burden causing disability and pain. Failure is caused by trauma at high loading rates. At the macroscopic level increasing…”
Get full text

The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization during Physiological Loading of Cartilage by Inamdar, Sheetal R, Knight, David P, Terrill, Nicholas J, Karunaratne, Angelo, Cacho-Nerin, Fernando, Knight, Martin M, Gupta, Himadri S

“…Articular cartilage is a natural biomaterial whose structure at the micro- and nanoscale is critical for healthy joint function and where degeneration is…”
Get full text

A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging by Stavri, Richard, Tay, Tabitha, Wiles, Crispin C, Di Federico, Erica, Boughton, Oliver, Ma, Shaocheng, Karunaratne, Angelo, Churchwell, John H, Bhattacharya, Rajarshi, Terrill, Nicholas J, Cobb, Justin P, Hansen, Ulrich, Abel, Richard L

“…Bone mechanics is well understood at every length scale except the nano-level. We aimed to investigate the relationship between bone nanoscale and tissue-level…”
Get full text

Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in rachitic bone: Evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging by Karunaratne, Angelo, Esapa, Christopher R, Hiller, Jennifer, Boyde, Alan, Head, Rosie, Bassett, JH Duncan, Terrill, Nicholas J, Williams, Graham R, Brown, Matthew A, Croucher, Peter I, Brown, Steve DM, Cox, Roger D, Barber, Asa H, Thakker, Rajesh V, Gupta, Himadri S

“…Bone diseases such as rickets and osteoporosis cause significant reduction in bone quantity and quality, which leads to mechanical abnormalities. However, the…”
Get full text

Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation by Arora, Hari, Nila, Alex, Vitharana, Kalpani, Sherwood, Joseph M., Nguyen, Thuy-Tien N., Karunaratne, Angelo, Mohammed, Idris K., Bodey, Andrew J., Hellyer, Peter J., Overby, Darryl R., Schroter, Robert C., Hollis, Dave

“…This study focuses on microstructural changes that occur within the mammalian lung when subject to blast and how these changes influence strain distributions…”
Get full text

Mechanical response of cortical bone in compression and tension at the mineralized fibrillar level in steroid induced osteoporosis by Xi, Li, Wen, Weibin, Wu, Wenwang, Qu, Zhaoliang, Tao, Ran, Karunaratne, Angelo, Liao, Binbin, Li, Ying, Fang, Daining

“…Nanocomposites like bone are used in vivo in a dynamic mechanical environment, and musculoskeletal fracture during traumatic events lead to pain and…”
Get full text

Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties by Ma, Shaocheng, Goh, En Lin, Jin, Andi, Bhattacharya, Rajarshi, Boughton, Oliver R., Patel, Bhavi, Karunaratne, Angelo, Vo, Nghia T., Atwood, Robert, Cobb, Justin P., Hansen, Ulrich, Abel, Richard L.

“…Osteoporosis is characterised by trabecular bone loss resulting from increased osteoclast activation and unbalanced coupling between resorption and formation,…”
Get full text

In situ 4D tomography image analysis framework to follow sintering within 3D‐printed glass scaffolds by Kondarage, Achintha I., Poologasundarampillai, Gowsihan, Nommeots‐Nomm, Amy, Lee, Peter D., Lalitharatne, Thilina D., Nanayakkara, Nuwan D., Jones, Julian R., Karunaratne, Angelo

“…We propose a novel image analysis framework to automate analysis of X‐ray microtomography images of sintering ceramics and glasses, using open‐source toolkits…”
Get full text

Nanoscale mechanisms in age-related hip-fractures by Ma, Shaocheng, Goh, En Lin, Tay, Tabitha, Wiles, Crispin C., Boughton, Oliver, Churchwell, John H., Wu, Yong, Karunaratne, Angelo, Bhattacharya, Rajarshi, Terrill, Nick, Cobb, Justin P., Hansen, Ulrich, Abel, Richard L.

“…Nanoscale mineralized collagen fibrils may be important determinants of whole-bone mechanical properties and contribute to the risk of age-related fractures…”
Get full text

Synchrotron Imaging Assessment of Bone Quality by Ma, Shaocheng, Boughton, Oliver, Karunaratne, Angelo, Jin, Andi, Cobb, Justin, Hansen, Ulrich, Abel, Richard

“…Bone is a complex hierarchical structure, and its principal function is to resist mechanical forces and fracture. Bone strength depends not only on the…”
Get full text

Strain rate dependency of fractures of immature bone by Cheong, Vee San, Karunaratne, Angelo, Amis, Andrew A., Bull, Anthony M.J.

“…Radiological features alone do not allow the discrimination between accidental paediatric long bone fractures or those sustained by child abuse. Therefore,…”
Get full text

Strain-rate sensitivity of the lateral collateral ligament of the knee by Bonner, Timothy J., Newell, Nicolas, Karunaratne, Angelo, Pullen, Andy D., Amis, Andrew A., M.J. Bull, Anthony, Masouros, Spyros D.

“…The material properties of ligaments are not well characterized at rates of deformation that occur during high-speed injuries. The aim of this study was to…”
Get full text

DISRUPTION OF MUSCLE STRESS-MEDIATED MINERAL ORIENTATION AT THE NANOSCALE IN THE SCAPULAR BONES OF RICKETS MICE WITH DEVELOPMENT by Karunaratne, Angelo, Davis, Graham, Hiller, Jen, Esapa, Chris, Terrill, Nick, Brown, Steve, Cox, Roger, Thakker, Rajesh, Gupta, Himadri

Get full text

Synchrotron X-ray nanomechanical imaging of mineralized fiber composites by Karunaratne, Angelo, Terrill, Nicholas J, Gupta, Himadri S

“…In situ synchrotron X-ray scattering and diffraction, in combination with micromechanical testing, can provide quantitative information on the nanoscale…”
Get more information

Analysis of alterations in matrix quality at nanoscale in metabolic bone diseases using synchrotron x-ray diffraction by Karunaratne, Malintha P. Angelo

“…Bone diseases such as osteoporosis and rickets cause significant reduction in bone quantity and quality, leading to mechanical abnormalities. While the…”
Get full text