Search Results - "Karube, Yoshiharu"

Menahydroquinone-4 may play a key role in regulating CCL5 expression induced by epidermal growth factor receptor inhibitors by Goto, Shotaro, Setoguchi, Shuichi, Watase, Daisuke, Yamakawa, Hirofumi, Yamada, Ayano, Koga, Mitsuhisa, Matsuo, Koichi, Matsunaga, Kazuhisa, Karube, Yoshiharu, Takata, Jiro

“…Epidermal growth factor receptor (EGFR) inhibitors frequently cause severe skin rash as a side effect, which is a critical burden for patients who continuously…”
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Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors by Terada, Kazuki, Migita, Keisuke, Matsushima, Yukari, Sugimoto, Yumi, Kamei, Chiaki, Matsumoto, Taichi, Mori, Masayoshi, Matsunaga, Kazuhisa, Takata, Jiro, Karube, Yoshiharu

“…Rivastigmine (Riv) is a potent and selective cholinesterase (acetylcholinesterase, AChE and butyrylcholinesterase, BuChE) inhibitor developed for the treatment…”
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Effects of fluvoxamine on nerve growth factor-induced neurite outgrowth inhibition by dexamethasone in PC12 cells by Matsushima, Yukari, Terada, Kazuki, Takata, Jiro, Karube, Yoshiharu, Kamei, Chiaki, Sugimoto, Yumi

“…In the present study, we examined the effects of fluvoxamine on nerve growth factor (NGF)-induced neurite outgrowth inhibition by dexamethasone (DEX) in PC12…”
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Inhibition of nerve growth factor-induced neurite outgrowth from PC12 cells by dexamethasone: signaling pathways through the glucocorticoid receptor and phosphorylated Akt and ERK1/2 by Terada, Kazuki, Kojima, Yoshitsugu, Watanabe, Takayuki, Izumo, Nobuo, Chiba, Koji, Karube, Yoshiharu

“…Glucocorticoids are important mediators of the stress response and are commonly employed as drugs for the suppression of immune rejection after organ…”
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Delivery of the reduced form of vitamin K2(20) to NIH/3T3 cells partially protects against rotenone induced cell death by Toki, Erina, Goto, Shotaro, Setoguchi, Shuichi, Terada, Kazuki, Watase, Daisuke, Yamakawa, Hirofumi, Yamada, Ayano, Koga, Mitsuhisa, Kubota, Kaori, Iwasaki, Katsunori, Karube, Yoshiharu, Matsunaga, Kazuhisa, Takata, Jiro

“…Mitochondria generate energy through the action of the electron transport chain (ETC) and ATP synthase. Mitochondrial malfunction can lead to various…”
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Cationic N,N-Dimethylglycine Ester Prodrug of 2R-α-Tocotrienol Promotes Intestinal Absorption via Efficient Self-Micellization with Intrinsic Bile Acid Anion by Watase, Daisuke, Setoguchi, Shuichi, Nagata-Akaho, Nami, Goto, Shotaro, Yamakawa, Hirofumi, Yamada, Ayano, Koga, Mitsuhisa, Karube, Yoshiharu, Matsunaga, Kazuhisa, Takata, Jiro

“…The intestinal absorption of hydrophobic compounds is severely influenced by their transportation rate through the unstirred water layer in the intestinal…”
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Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions by Setoguchi, Shuichi, Hidaka, Ryoji, Nagata-Akaho, Nami, Watase, Daisuke, Koga, Mitsuhisa, Matsunaga, Kazuhisa, Karube, Yoshiharu, Takata, Jiro

“…The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10…”
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Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study by Terada, Kazuki, Murata, Ayumi, Toki, Erina, Goto, Shotaro, Yamakawa, Hirofumi, Setoguchi, Shuichi, Watase, Daisuke, Koga, Mitsuhisa, Takata, Jiro, Matsunaga, Kazuhisa, Karube, Yoshiharu

“…Schizophrenia is a severe, chronic mental illness characterized by delusions, hallucinations, negative symptoms, and cognitive dysfunction. Recently, several…”
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Prodrugs for Skin Delivery of Menahydroquinone-4, an Active Form of Vitamin K2(20), Could Overcome the Photoinstability and Phototoxicity of Vitamin K2(20) by Goto, Shotaro, Setoguchi, Shuichi, Yamakawa, Hirofumi, Watase, Daisuke, Terada, Kazuki, Matsunaga, Kazuhisa, Karube, Yoshiharu, Takata, Jiro

“…The effective delivery of menahydroquinone-4 (MKH), an active form of menaquinone-4 (MK-4, vitamin K2(20)), to the skin is beneficial in the treatment of…”
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Antitumor Effects and Delivery Profiles of Menahydroquinone-4 Prodrugs with Ionic or Nonionic Promoiety to Hepatocellular Carcinoma Cells by Setoguchi, Shuichi, Watase, Daisuke, Matsunaga, Kazuhisa, Yamakawa, Hirofumi, Goto, Shotaro, Terada, Kazuki, Ohe, Kenji, Enjoji, Munechika, Karube, Yoshiharu, Takata, Jiro

“…Hepatocellular carcinoma (HCC) shows poor prognosis owing to its very frequent recurrence even after curative treatment. Thus, an effective and safe long-term…”
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Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction by Tsuji, Yasuhiro, Mizoguchi, Akiko, Sadoh, Shinichi, Hiraki, Yoichi, Matsumoto, Kana, Morita, Kunihiko, Kobayashi, Tsutomu, Kamimura, Hidetoshi, Karube, Yoshiharu

“…Abstract It has been proposed that it is not necessary to adjust the dose of linezolid (LZD) in patients with reduced renal function. However, significantly…”
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Evaluation of pharmacokinetics and the stability of daptomycin in serum at various temperatures by Ogami, Chika, Tsuji, Yasuhiro, Kasai, Hidefumi, Hiraki, Yoichi, Yamamoto, Yoshihiro, Matsunaga, Kazuhisa, Karube, Yoshiharu, To, Hideto

“…Summary Background Daptomycin exhibits concentration-dependent antibacterial activity. By monitoring daptomycin serum concentrations, clinicians may be able to…”
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Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K2(20), on All-Trans Retinoic Acid-Resistant HL60 Cell Line by Yamakawa, Hirofumi, Setoguchi, Shuichi, Goto, Shotaro, Watase, Daisuke, Terada, Kazuki, Nagata-Akaho, Nami, Toki, Erina, Koga, Mitsuhisa, Matsunaga, Kazuhisa, Karube, Yoshiharu, Takata, Jiro

“…The first-choice drug for acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA), frequently causes drug-resistance and some adverse effects. Thus,…”
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Comparison of predictive accuracy of teicoplanin concentration using creatinine clearance and glomerular filtration rate estimated by serum creatinine or cystatin C by Kozono, Aki, Hiraki, Yoichi, Ph.D, Adachi, Rui, Nagano, Masahisa, Inoue, Daisuke, Tsuji, Yasuhiro, Kamimura, Hidetoshi, Karube, Yoshiharu

“…Abstract We compared the predictive accuracy of TEIC concentrations (TEIC _conc ) calculated using either serum cystatin C (CysC) or serum creatinine (SCr) and…”
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Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades by Terada, Kazuki, Izumo, Nobuo, Suzuki, Biora, Karube, Yoshiharu, Morikawa, Tomomi, Ishibashi, Yukiko, Kameyama, Toshiki, Chiba, Koji, Sasaki, Noriko, Iwata, Keiko, Matsuzaki, Hideo, Manabe, Takayuki

“…Major depression is a complex disorder characterized by genetic and environmental interactions. Selective serotonin reuptake inhibitors (SSRIs) effectively…”
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Isolation of genetically indistinguishable carbapenem-resistant and -susceptible Acinetobacter baumannii isolates from a single patient by Matsui, Mari, Shibayama, Keigo, Tsuji, Yasuhiro, Kamimura, Hidetoshi, Karube, Yoshiharu, Yoshida, Mayumi, Masuda, Yoko, Hiraki, Yoichi, Takaki, Kazutaka, Kawano, Fumio

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Influence of Linezolid Clearance on the Induction of Thrombocytopenia and Reduction of Hemoglobin by Hiraki, Yoichi, BSc, Tsuji, Yasuhiro, PhD, Matsumoto, Kana, PhD, Morita, Kunihiko, PhD, Kamimura, Hidetoshi, PhD, Karube, Yoshiharu, PhD

“…Abstract Introduction Although linezolid (LZD) has proven effective for the treatment of infections caused by multidrug-resistant Gram-positive cocci,…”
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Elevations of urinary pH may lower vancomycin serum concentration by Hiraki, Yoichi, Tsuji, Yasuhiro, Yasumori, Naoko, Nagano, Masahisa, Inoue, Daisuke, Kamimura, Hidetoshi, Karube, Yoshiharu, Kawano, Fumio

“…This study investigated endogenous factors that may increase the elimination of vancomycin (VCM) in adult methicillin-resistant Staphylococcus aureus (MRSA)…”
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Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica by Yoshida, Miyako, Fuchigami, Masahiro, Nagao, Tsuneatsu, Okabe, Hikaru, Matsunaga, Kazuhisa, Takata, Jiro, Karube, Yoshiharu, Tsuchihashi, Ryota, Kinjo, Junei, Mihashi, Kunihide, Fujioka, Toshihiro

“…The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH…”
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Pharmacokinetics of repeated dosing of linezolid in a hemodialysis patient with chronic renal failure by Tsuji, Yasuhiro, Mizoguchi, Akiko, Hiraki, Yoichi, Hayashi, Waka, Kamohara, Ryotaro, Kamimura, Hidetoshi, Karube, Yoshiharu

“…Abstract Linezolid (LZD) is thought not to require dose adjustment in patients with renal dysfunction, making it a drug of choice for these patients. However,…”
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