Search Results - "Karu, Alexander E."

Immunochemical detection of polycyclic aromatic hydrocarbons and 1-hydroxypyrene in water and sediment samples by Li, Kai, Woodward, Lee Ann, Karu, Alexander E, Li, Qing X

“…Several approaches were investigated to fully use an enzyme linked immunosorbent assay (ELISA) for accurate measurement of polycyclic aromatic hydrocarbons…”
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Structural basis for preferential binding of non-ortho-substituted polychlorinated biphenyls by the monoclonal antibody S2B1 by Pellequer, Jean-Luc, Chen, Shu-wen W., Keum, Young-soo, Karu, Alexander E., Li, Qing Xiao, Roberts, Victoria A.

“…Polychlorinated biphenyls (PCBs) are a family of 209 isomers (congeners) with a wide range of toxic effects. In structural terms, they are of two types: those…”
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Derivation and Properties of Recombinant Fab Antibodies to Coplanar Polychlorinated Biphenyls by Chiu, Ya-Wen, Chen, Rongliang, Li, Qing X, Karu, Alexander E

“…Recombinant Fab antibodies (rFabs) specific for coplanar polychlorinated biphenyls (PCBs) were derived from a hybridoma cell line (Chiu et al. Anal. Chem…”
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A Monoclonal Immunoassay for the Coplanar Polychlorinated Biphenyls by Chiu, Ya-Wen, Carlson, Robert E, Marcus, Karen L, Karu, Alexander E

“…Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants with diverse toxic, teratogenic, reproductive, immunotoxic, and tumorigenic effects…”
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Synthesis of Haptens and Derivation of Monoclonal Antibodies for Immunoassay of the Phenylurea Herbicide Diuron by Karu, Alexander E, Goodrow, Marvin H, Schmidt, Douglas J, Hammock, Bruce D, Bigelow, Michael W

“…Diuron and related phenylurea herbicides and their metabolites are important candidates for sensitive and specific immunodetection. This paper describes a…”
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Selective Binding of Polychlorinated Biphenyl Congeners by a Monoclonal Antibody:  Analysis by Kinetic Exclusion Fluorescence Immunoassay by Chiu, Ya-Wen, Li, Qing X, Karu, Alexander E

“…A previously described monoclonal antibody, S2B1, was highly selective for coplanar (non-ortho-chlorinated) PCB congeners in enzyme immunoassays that measured…”
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Haptens and Monoclonal Antibodies for Immunoassay of Imidazolinone Herbicides by Chin, Tina E, Wong, Rosie B, Pont, Joseph L, Karu, Alexander E

“…A set of haptens structurally resembling the herbicide imazethapyr (PURSUIT) was synthesized and used to derive monoclonal antibodies (MAbs) and direct and…”
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Stabilization of bound polycyclic aromatic hydrocarbons by a π-cation interaction by Pellequer, Jean-Luc, Zhao, Bitao, Kao, Hui-I., Bell, Christopher W., Li, Kai, Li, Qing X., Karu, Alexander E., Roberts, Victoria A.

“…Proteins can use aromatic side-chains to stabilize bound cationic ligands through cation-π interactions. Here, we report the first example of the reciprocal…”
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Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLC by Girault, Isabelle, Karu, Alexander E, Schaper, Manuela, Barcellos-Hoff, Mary Helen, Hagen, Tory, Vogel, David S, Ames, Bruce N, Christen, Stephan, Shigenaga, Mark K

“…Zymosan-induced peritonitis is associated with an increased production of reactive nitrogen oxides that may contribute to the often-observed failure of…”
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Monoclonal Antibody-Based ELISAs for Part-per-Billion Determination of Polycyclic Aromatic Hydrocarbons:  Effects of Haptens and Formats on Sensitivity and Specificity by Li, Kai, Chen, Rongliang, Zhao, Bitao, Liu, Mei, Karu, Alexander E, Roberts, Victoria A, Li, Qing X

“…As a first step toward developing sensitive enzyme-linked immunosorbent assays (ELISAs) for multianalyte detection of polycyclic aromatic hydrocarbons (PAHs),…”
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Derivation and Properties of Recombinant Fab Antibodies to the Phenylurea Herbicide Diuron by Scholthof, Karen-Beth G., Zhang, Guisheng, Karu, Alexander E.

“…The Fab domain sequences from messenger RNA of a mouse hybridoma cell line secreting a monoclonal antibody (MAb) specific for the phenylurea herbicide diuron…”
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Recognition of tetramethylenedisulfotetramine and related sulfamides by the brain GABA-gated chloride channel and a cyclodiene-sensitive monoclonal antibody by Esser, Thomas, Karu, Alexander E, Toia, Robert F, Casida, John E

“…Aldrin and many other cyclodiene and polychlorocycloalkane insecticides interact with both the [35S]-tert-butylbicyclophosphorothionate ([35S]TBPS) binding…”
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Validation of a Monoclonal Immunoassay for Diuron in Groundwater by Karu, Alexander E, Schmidt, Douglas J, Richman, Sylvia J, Cooper, Catherine, Tran, Duc, Hsu, Jean

“…Diuron is one of the most heavily used herbicides in California, and well water and surface water are routinely monitored for diuron residues. In a previous…”
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Monoclonal antibodies for immunoassay of avermectins by Schmidt, Douglas J, Clarkson, Carolyn E, Swanson, Todd A, Egger, Marie L, Carlson, Robert E, Van Emon, Jeanette M, Karu, Alexander E

“…We have developed a panel of mouse monoclonal antibodies (MAbs) that recognize ivermectin and abamectin, the major avermectins used in veterinary and…”
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Uncoupling of the recBC ATPase from DNase by DNA Crosslinked with Psoralen by Karu, Alexander E., Linn, Stuart

“…Exonucleolytic cleavage of DNA by the recBC DNase is accompanied by a DNA-dependent ATP hydrolysis that ceases when the DNA has been digested to a limit. On…”
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Purification and Properties of the γ -Protein Specified by Bacteriophage λ : An Inhibitor of the Host RecBC Recombination Enzyme by Sakaki, Yoshiyuki, Karu, Alexander E., Linn, Stuart, Echols, Harrison

“…Previous experiments have indicated that the gam gene of bacteriophage λ is responsible for an inhibition of the RecBC DNase--an enzyme that is essential for…”
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The recBC Deoxyribonuclease of Escherichia coli K-12 by Karu, Alexander E., MacKay, Vivian, Goldmark, Peter J., Linn, Stuart

“…The behavior of the recBC DNase of Escherichia coli with a variety of substrates has been investigated. Duplex circular DNA is resistant to digestion, is not a…”
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Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: Comparison to analysis by HPLC by Giraut, Isabelle, Karu, Alexander E., Schaper, Manuela, Barcellos-Hoff, Mary Helen, Hagen, Tory, Vogel, David S., Ames, Bruce N., Christen, Stephan, Shigenaga, Mark K.

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Sequences of the cDNAs encoding the heavy- and light-chain Fab region of an antibody to the phenylurea herbicide diuron by Bell, C W, Scholthof, K B, Zhang, G, Karu, A E

“…The cDNAs from a hybridoma (mAb 481.1) specific for diuron, a widely used phenylurea herbicide, were cloned into the phage display vector pComb8…”
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Selective immunoneutralization of the multiple activities of Escherichia coli DNA polymerase I supports the model for separate active sites and indicates a complex 5' to 3' exonuclease by Ruscitti, T, Polayes, D A, Karu, A E, Linn, S

“…DNA polymerase I (pol I) from Escherichia coli has three well-defined activities: DNA polymerase, 3'-5' exonuclease, and 5'-3' exonuclease. We have raised…”
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