Search Results - "Karton, Yishai"

Novel synthetic approach in microwave-assisted solid-supported oxidations using ‘in situ’ generated molecular oxygen by Gershonov, Eytan, Katz, Esther, Karton, Yishai, Zafrani, Yossi

“…Three different types of oxidation reactions were carried out under microwave (MW) conditions in dry media, with nearly quantitative yield, using ‘in situ’,…”
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Synthesis and Biological Activities of Flavonoid Derivatives as A3 Adenosine Receptor Antagonists by Karton, Yishai, Jiang, Ji-long, Ji, Xiao-duo, Melman, Neli, Olah, Mark E, Stiles, Gary L, Jacobson, Kenneth A

“…A broad screening of phytochemicals has demonstrated that certain flavone and flavonol derivatives have a relatively high affinity at A3 adenosine receptors,…”
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Novel salicylazo polymers for colon drug delivery: dissolving polymers by means of bacterial degradation by Saphier, Sigal, Karton, Yishai

“…Novel azo polymers were prepared for colonic drug delivery with a release mechanism based on structural features of azo derivatives designed for rapid…”
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Gastro intestinal tracking and gastric emptying of solid dosage forms in rats using X-ray imagining by Saphier, Sigal, Rosner, Amir, Brandeis, Rachel, Karton, Yishai

“…The aim of this research was to study the gastrointestinal transit and gastric emptying of non-disintegrating solid dosage forms in rats using X-ray imaging…”
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Novel m1 muscarinic agonists in treatment and delaying the progression of Alzheimer's disease: An unifying hypothesis by Fisher, Abraham, Brandeis, Rachel, Haring, Rachel, Eshhar, Naomi, Heldman, Eliahu, Karton, Yishai, Eisenberg, Orli, Meshulam, Haim, Marciano, Daniele, Bar-Ner, Nira, Pittel, Zipora

“…M1 selective agonists from the AF series (e.g. AF102B, AF150(S)), via m1 muscarinic receptors, activate distinct signal transductions, enhance amyloid…”
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Functionalized congener approach to muscarinic antagonists: analogs of pirenzepine by Karton, Yishai, Bradbury, Barton J, Baumgold, Jesse, Paek, Robert, Jacobson, Kenneth A

“…The M1-selective muscarinic receptor antagonist pirenzepine 6H-pyrido[2,3-b][1,4]benzodiazepin-6-one) was derivatized to explore points of attachment of…”
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Nucleophilic transformations of cyclic phosphate triesters by Ashkenazi, Nissan, Karton, Yishai, Segall, Yoffi

“…[Display omitted] Reactions of cyclic phosphate triesters, such as 2-ethoxy-1,3,2-dioxaphospholane 2-oxide, with Grignard reagents such as phenyl-, alkyl-,…”
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Stereoselectivity toward VX Is Determined by Interactions with Residues of the Acyl Pocket as Well as of the Peripheral Anionic Site of AChE by Ordentlich, Arie, Barak, Dov, Sod-Moriah, Gali, Kaplan, Dana, Mizrahi, Dana, Segall, Yoffi, Kronman, Chanoch, Karton, Yishai, Lazar, Arie, Marcus, Dino, Velan, Baruch, Shafferman, Avigdor

“…The origins of human acetylcholinesterase (HuAChE) reactivity toward the lethal chemical warfare agent O-ethyl S-[2-(diisopropylamino)ethyl]…”
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Gastro intestinal tracking and gastric emptying of solid dosage forms in rats using X-ray imaging by Saphier, Sigal, Rosner, Amir, Brandeis, Rachel, Karton, Yishai

“…The aim of this research was to study the gastrointestinal transit and gastric emptying of non-disintegrating solid dosage forms in rats using X-ray imaging…”
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Ambident Electrophilicity of 5-Membered Ring Phosphate Triesters by Ashkenazi, Nissan, Segall, Yoffi, Karton, Yishai, Zade, Sanjio S., Bendikov, Michael

“…The reactions of 2-alkoxy-1,3,2-dioxaphospholane 2-oxide with various nucleophiles were studied both experimentally and theoretically. These studies show that…”
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The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers by Ordentlich, Arie, Barak, Dov, Sod-Moriah, Gali, Kaplan, Dana, Mizrahi, Dana, Segall, Yoffi, Kronman, Chanoch, Karton, Yishai, Lazar, Arie, Marcus, Dino, Velan, Baruch, Shafferman, Avigdor

“…The reactivity of human acetylcholinesterase (HuAChE) toward the chemical warfare agent VX { O-ethyl S-[2-(diisopropylamino)ethyl] methyl-phosphonothioate} and…”
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Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists by Jacobson, Kenneth A, Gallo-Rodriguez, Carola, Melman, Neli, Fischer, Bilha, Maillard, Michel, van Bergen, Andrew, van Galen, Philip J. M, Karton, Yishai

“…A series of substituted 8-styryl derivatives of 1,3,7-alkylxanthines was synthesized as potential A2-selective adenosine receptor antagonists, and the potency…”
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Amyloid precursor protein secretion via muscarinic receptors: reduced desensitization using the M1-selective agonist AF102B by Haring, R, Gurwitz, D, Barg, J, Pinkas-Kramarski, R, Heldman, E, Pittel, Z, Wengier, A, Meshulam, H, Marciano, D, Karton, Y

“…Secretion of amyloid precursor protein (APP) by cultured cells is coupled to several receptors, including m1 muscarinic (m1AChR), and is associated with…”
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NGF Promotes Amyloid Precursor Protein Secretion via Muscarinic Receptor Activation by Haring, R., Gurwitz, D., Barg, J., Pinkaskramarski, R., Heldman, E., Pittel, Z., Danenberg, H.D., Wengier, A., Meshulam, H., Marciano, D., Karton, Y., Fisher, A.

“…Processing of β-amyloid precursor protein (APP) is coupled to several neurotransmitter receptors, including m1 muscarinic (m1AChR), and is associated with…”
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Synthesis and Biological Activities of Flavonoid Derivatives as A 3 Adenosine Receptor Antagonists by Karton, Yishai, Jiang, Ji-long, Ji, Xiao-duo, Melman, Neli, Olah, Mark E., Stiles, Gary L., Jacobson, Kenneth A.

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Acyl-Hydrazide Derivatives of a Xanthine Carboxylic Congener (XCC) as Selective Antagonists at Human A 2B Adenosine Receptors by Kim, Yong-Chul, Karton, Yishai, Ji, Xiao-Duo, Melman, Neli, Linden, Joel, Jacobson, Kenneth A

“…The structure-activity relationships (SAR) of 8-phenyl-1,3-dipropylxanthine derivatives in binding to recombinant human A adenosine receptors were explored, in…”
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Acyl-hydrazide derivatives of a xanthine carboxylic congener (XCC) as selective antagonists at human A2B adenosine receptors by Kim, Yong-Chul, Karton, Yishai, Ji, Xiao-duo, Melman, Neli, Linden, Joel, Jacobson, Kenneth A.

“…The structure–activity relationships (SAR) of 8‐phenyl‐1,3‐dipropylxanthine derivatives in binding to recombinant human A2B adenosine receptors were explored,…”
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Molecular probes for muscarinic receptors: derivatives of the M1-antagonist telenzepine by Karton, Yishai, Baumgold, Jesse, Handen, Jeffrey S, Jacobson, Kenneth A

“…Functionalized congeners of the M1-selective muscarinic antagonist telenzepine (4,9-dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-…”
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High affinity acylating antagonists for muscarinic receptors by Baumgold, J, Karton, Y, Malka, N, Jacobson, K A

“…The muscarinic antagonists pirenzepine and telenzepine were derivatized as alkylamino derivatives at a site on the molecules corresponding to a region of bulk…”
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