Search Results - "Karsunky, H"

Regulation of pre-T-cell development by Möröy, T, Karsunky, H

“…One important pillar of cellular immune defense in mammals is the T-lymphoid compartment which produces cells that are able to specifically recognize foreign…”
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Comprehensive methylome map of lineage commitment from haematopoietic progenitors by Feinberg, Andrew P, Ji, Hong, Ehrlich, Lauren I. R, Seita, Jun, Murakami, Peter, Doi, Akiko, Lindau, Paul, Lee, Hwajin, Aryee, Martin J, Irizarry, Rafael A, Kim, Kitai, Rossi, Derrick J, Inlay, Matthew A, Serwold, Thomas, Karsunky, Holger, Ho, Lena, Daley, George Q, Weissman, Irving L

“…Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA…”
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Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors by Cozzio, Antonio, Passegué, Emmanuelle, Ayton, Paul M, Karsunky, Holger, Cleary, Michael L, Weissman, Irving L

“…We have used the hematopoietic system as a model to investigate whether acute myeloid leukemia arises exclusively from self-renewing stem cells or also from…”
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Langerhans cells renew in the skin throughout life under steady-state conditions by Merad, Miriam, Manz, Markus G, Karsunky, Holger, Wagers, Amy, Peters, Wendy, Charo, Israel, Weissman, Irving L, Cyster, Jason G, Engleman, Edgar G

“…Langerhans cells (LCs) are bone marrow (BM)-derived epidermal dendritic cells (DCs) that represent a critical immunologic barrier to the external environment,…”
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Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo by Karsunky, Holger, Merad, Miriam, Cozzio, Antonio, Weissman, Irving L, Manz, Markus G

“…Stimulation of Flt3 receptor tyrosine kinase through its cognate ligand expands early hematopoietic progenitor and dendritic cells (DCs) in humans and mice…”
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Features of systemic lupus erythematosus in Dnase1-deficient mice by Möröy, Tarik, Napirei, Markus, Karsunky, Holger, Zevnik, Branko, Stephan, Harald, M annherz, Hans Georg

“…Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that affects over one million people in the United States. SLE is characterized by…”
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The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus by Yücel, Raif, Karsunky, Holger, Klein-Hitpass, Ludger, Möröy, Tarik

“…In the thymus, several steps of proliferative expansion and selection coordinate the maturation of precursors into antigen-specific T cells. Here we identify…”
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Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1 by Möröy, Tarik, Karsunky, Holger, Zeng, Hui, Schmidt, Thorsten, Zevnik, Branko, Kluge, Reinhart, Schmid, Kurt Werner, Dührsen, Ulrich

“…The transcriptional repressor Gfi1 is a nuclear zinc-finger protein expressed in T-cell precursors in the thymus and in activated mature T lymphocytes…”
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MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice by So, Chi Wai, Karsunky, Holger, Passegué, Emmanuelle, Cozzio, Antonio, Weissman, Irving L, Cleary, Michael L

“…A specific association with mixed lineage leukemias suggests that MLL oncoproteins may selectively target early multipotent hematopoietic progenitors or stem…”
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Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9 by CHI WAI SO, KARSUNKY, Holger, PIU WONG, WEISSMAN, Irving L, CLEARY, Michael L

“…Differential expression of Hox genes is associated with normal hematopoiesis, whereas inappropriate maintenance of Hox gene expression, particularly Hoxa7 and…”
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High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells by Karsunky, H, Mende, I, Schmidt, T, Moeroey, T

“…Gfi-1 is a nuclear zinc finger protein with the activity of a transcriptional repressor and the ability to predispose for the development of T-cell lymphoma…”
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Miz1 Is Required for Early Embryonic Development during Gastrulation by Adhikary, Sovana, Peukert, Karen, Karsunky, Holger, Beuger, Vincent, Lutz, Werner, Elsässer, Hans-Peter, Möröy, Tarik, Eilers, Martin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Flk2+ myeloid progenitors are the main source of Langerhans cells by Mende, Ines, Karsunky, Holger, Weissman, Irving L., Engleman, Edgar G., Merad, Miriam

“…Langerhans cells (LCs) are antigen-presenting cells (APCs) residing in the epidermis that play a major role in skin immunity. Our earlier studies showed that…”
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Developmental origin of interferon-α–producing dendritic cells from hematopoietic precursors by Karsunky, Holger, Merad, Miriam, Mende, Ines, Manz, Markus G., Engleman, Edgar G., Weissman, Irving L.

“…The aim of this study was to determine the lineage origin of interferon-α–producing cells (IPCs), also called plasmacytoid dendritic cells, in mice by…”
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The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3 by Rödel, Bernd, Tavassoli, Kamiab, Karsunky, Holger, Schmidt, Thorsten, Bachmann, Malte, Schaper, Fred, Heinrich, Peter, Shuai, Ke, Elsässer, Hans Peter, Möröy, Tarik

“…STAT factors act as signal transducers of cytokine receptors and transcriptionally activate specific target genes. The recently discovered protein PIAS3 binds…”
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Loss of p27 cooperates with cyclin E in T-cell lymphomagenesis by Geisen, Christoph, Karsunky, Holger, Yücel, Raif, Möröy, Tarik

“…Cyclin E and p27(Kip1) are key regulators for cyclin-dependent kinases (Cdks) acting at the G1-/S-phase transition of the cell cycle. Whereas cyclin E is…”
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Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events by Beier, Rudolf, Bürgin, Andrea, Kiermaier, Astrid, Fero, Matthew, Karsunky, Holger, Saffrich, Rainer, Möröy, Tarik, Ansorge, Wilhelm, Roberts, Jim, Eilers, Martin

“…The c‐myc gene has been implicated in three distinct genetic programs regulating cell proliferation: control of cyclin E–cdk2 kinase activity, E2F‐dependent…”
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CD101 surface expression discriminates potency among murine FoxP3+ regulatory T cells by Fernandez, I., Zeiser, R., Karsunky, H., Kambham, N., Beilhack, A., Soderstrom, K., Negrin, R. S., Engleman, E.

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Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis by SCHMIDT, T, KARSUNKY, H, GAU, E, ZEVNIK, B, ELSÄSSER, H.-P, MÖRÖY, T

“…The gfi-1 gene encodes a zinc finger containing protein that is specifically expressed in T-lymphocytes and is a frequent target of proviral insertion in…”
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The Transcriptional Repressor Gfi1 Affects Development of Early, Uncommitted c-Kit super(+) T Cell Progenitors and CD4/CD8 Lineage Decision in the Thymus by Yuecel, R, Karsunky, H, Klein-Hitpass, L, Moeroey, T

“…In the thymus, several steps of proliferative expansion and selection coordinate the maturation of precursors into antigen-specific T cells. Here we identify…”
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