Search Results - "Karsten Quast"

BAL Cell Gene Expression Is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary Fibrosis by Prasse, Antje, Binder, Harald, Schupp, Jonas C, Kayser, Gian, Bargagli, Elena, Jaeger, Benedikt, Hess, Moritz, Rittinghausen, Susanne, Vuga, Louis, Lynn, Heather, Violette, Shelia, Jung, Birgit, Quast, Karsten, Vanaudenaerde, Bart, Xu, Yan, Hohlfeld, Jens M, Krug, Norbert, Herazo-Maya, Jose D, Rottoli, Paola, Wuyts, Wim A, Kaminski, Naftali

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease with a variable and unpredictable course. To determine whether BAL cell gene expression is predictive of…”
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Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture by Gindele, Julia A., Kiechle, Tobias, Benediktus, Kerstin, Birk, Gerald, Brendel, Michael, Heinemann, Fabian, Wohnhaas, Christian T., LeBlanc, Michelle, Zhang, Haijun, Strulovici-Barel, Yael, Crystal, Ronald G., Thomas, Matthew J., Stierstorfer, Birgit, Quast, Karsten, Schymeinsky, Jürgen

“…Cigarette smoke (CS) is the leading risk factor to develop COPD. Therefore, the pathologic effects of whole CS on the differentiation of primary small airway…”
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Dysregulation of club cell biology in idiopathic pulmonary fibrosis by Zuo, Wu-Lin, Rostami, Mahboubeh R, LeBlanc, Michelle, Kaner, Robert J, O'Beirne, Sarah L, Mezey, Jason G, Leopold, Philip L, Quast, Karsten, Visvanathan, Sudha, Fine, Jay S, Thomas, Matthew J, Crystal, Ronald G

“…Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic fibrotic lung disease with an irreversible decline of lung function. "Bronchiolization",…”
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A Novel Fibroblast Reporter Cell Line for in vitro Studies of Pulmonary Fibrosis by Nemeth, Julia, Schundner, Annika, Quast, Karsten, Winkelmann, Veronika E, Frick, Manfred

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease of the lower respiratory tract with restricted therapeutic options. Repetitive injury of the…”
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Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity by Wang, Guoqing, Lou, Howard H, Salit, Jacqueline, Leopold, Philip L, Driscoll, Sharon, Schymeinsky, Juergen, Quast, Karsten, Visvanathan, Sudha, Fine, Jay S, Thomas, Matthew J, Crystal, Ronald G

“…The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium…”
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RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma by Lamb, David, De Sousa, Dorothy, Quast, Karsten, Fundel-Clemens, Katrin, Erjefält, Jonas S, Sandén, Caroline, Hoffmann, Hans Jürgen, Kästle, Marc, Schmid, Ramona, Menden, Kevin, Delic, Denis

“…RORγt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target…”
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Effect of RNA quality on transcript intensity levels in microarray analysis of human post-mortem brain tissues by Popova, Tatiana, Mennerich, Detlev, Weith, Andreas, Quast, Karsten

“…Large-scale gene expression analysis of post-mortem brain tissue offers unique opportunities for investigating genetic mechanisms of psychiatric and…”
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The FAIR Cookbook - the essential resource for and by FAIR doers by Rocca-Serra, Philippe, Gu, Wei, Ioannidis, Vassilios, Abbassi-Daloii, Tooba, Capella-Gutierrez, Salvador, Chandramouliswaran, Ishwar, Splendiani, Andrea, Burdett, Tony, Giessmann, Robert T., Henderson, David, Batista, Dominique, Emam, Ibrahim, Gadiya, Yojana, Giovanni, Lucas, Willighagen, Egon, Evelo, Chris, Gray, Alasdair J. G., Gribbon, Philip, Juty, Nick, Welter, Danielle, Quast, Karsten, Peeters, Paul, Plasterer, Tom, Wood, Colin, van der Horst, Eelke, Reilly, Dorothy, van Vlijmen, Herman, Scollen, Serena, Lister, Allyson, Thurston, Milo, Granell, Ramon, Sansone, Susanna-Assunta

“…The notion that data should be Findable, Accessible, Interoperable and Reusable, according to the FAIR Principles, has become a global norm for good data…”
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Cell-specific expression of lung disease risk-related genes in the human small airway epithelium by Zuo, Wu-Lin, Rostami, Mahboubeh R, Shenoy, Shushila A, LeBlanc, Michelle G, Salit, Jacqueline, Strulovici-Barel, Yael, O'Beirne, Sarah L, Kaner, Robert J, Leopold, Philip L, Mezey, Jason G, Schymeinsky, Juergen, Quast, Karsten, Visvanathan, Sudha, Fine, Jay S, Thomas, Matthew J, Crystal, Ronald G

“…The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is…”
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Comparison of normalization methods for Illumina BeadChip HumanHT-12 v3 by Schmid, Ramona, Baum, Patrick, Ittrich, Carina, Fundel-Clemens, Katrin, Huber, Wolfgang, Brors, Benedikt, Eils, Roland, Weith, Andreas, Mennerich, Detlev, Quast, Karsten

“…Normalization of microarrays is a standard practice to account for and minimize effects which are not due to the controlled factors in an experiment. There is…”
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Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization by Baum, Patrick, Schmid, Ramona, Ittrich, Carina, Rust, Werner, Fundel-Clemens, Katrin, Siewert, Susanne, Baur, Martin, Mara, Lisa, Gruenbaum, Lore, Heckel, Armin, Eils, Roland, Kontermann, Roland E, Roth, Gerald J, Gantner, Florian, Schnapp, Andreas, Park, John E, Weith, Andreas, Quast, Karsten, Mennerich, Detlev

“…A phenocopy is defined as an environmentally induced phenotype of one individual which is identical to the genotype-determined phenotype of another individual…”
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PDE4B inhibition by nerandomilast: Effects on lung fibrosis and transcriptome in fibrotic rats and on biomarkers in human lung epithelial cells by Reininger, Dennis, Fundel‐Clemens, Katrin, Mayr, Christoph H., Wollin, Lutz, Laemmle, Baerbel, Quast, Karsten, Nickolaus, Peter, Herrmann, Franziska Elena

“…Background and Purpose The PDE4 family is considered a prime target for therapeutic intervention in several fibro‐inflammatory diseases. We have investigated…”
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Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in a human iPSC‐derived air‐liquid interface model by Schruf, Eva, Schroeder, Victoria, Le, Huy Q., Schönberger, Tanja, Raedel, Dagmar, Stewart, Emily L., Fundel‐Clemens, Katrin, Bluhmki, Teresa, Weigle, Sabine, Schuler, Michael, Thomas, Matthew J., Heilker, Ralf, Webster, Megan J., Dass, Martin, Frick, Manfred, Stierstorfer, Birgit, Quast, Karsten, Garnett, James P.

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease of unknown cause that is characterized by progressive fibrotic lung remodeling. An abnormal emergence of…”
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Transcriptomic and proteomic profiling of young and old mice in the bleomycin model reveals high similarity by Klee, Stephan, Picart-Armada, Sergio, Wenger, Kathrin, Birk, Gerald, Quast, Karsten, Veyel, Daniel, Rist, Wolfgang, Violet, Coralie, Luippold, Andreas, Haslinger, Christian, Thomas, Matthew, Fernandez-Albert, Francesc, Kästle, Marc

“…The most common preclinical, in vivo model to study lung fibrosis is the bleomycin-induced lung fibrosis model in 2- to 3-mo-old mice. Although this model…”
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An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury by Le, Huy Q, Hill, Matthew A, Kollak, Ines, Keck, Martina, Schroeder, Victoria, Wirth, Johannes, Skronska-Wasek, Wioletta, Schruf, Eva, Strobel, Benjamin, Stahl, Heiko, Herrmann, Franziska E, Campos, Alexandre R, Li, Jun, Quast, Karsten, Knebel, Dagmar, Viollet, Coralie, Thomas, Matthew J, Lamb, David, Garnett, James P

“…Unveiling the molecular mechanisms of tissue remodelling following injury is imperative to elucidate its regenerative capacity and aberrant repair in disease…”
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ROR[gamma]t inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma by Lamb, David, De Sousa, Dorothy, Quast, Karsten, Fundel-Clemens, Katrin, Erjefält, Jonas S, Sandén, Caroline, Hoffmann, Hans Jürgen, Kästle, Marc, Schmid, Ramona, Menden, Kevin, Delic, Denis

“…Background ROR[gamma]t is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a…”
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Key factors for successful data integration in biomarker research by Elefsinioti, Antigoni, Bellaire, Tanja, Wang, Albert, Quast, Karsten, Seidel, Henrik, Braxenthaler, Michael, Goeller, Gernot, Christianson, Anastasia, Henderson, David, Reischl, Joachim

“…Integrating a wide range of biomedical data such as that rapidly emerging from the use of next-generation sequencing is expected to have a key role in…”
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High‐resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD by Schwartz, Uwe, Llamazares Prada, Maria, Pohl, Stephanie T, Richter, Mandy, Tamas, Raluca, Schuler, Michael, Keller, Corinna, Mijosek, Vedrana, Muley, Thomas, Schneider, Marc A, Quast, Karsten, Hey, Joschka, Heußel, Claus P, Warth, Arne, Winter, Hauke, Serçin, Özdemirhan, Karmouty‐Quintana, Harry, Jyothula, Soma SK, Patel, Manish K, Herth, Felix, Koch, Ina, Petrosino, Giuseppe, Titimeaua, Alexandru, Mardin, Balca R, Weichenhan, Dieter, Jurkowski, Tomasz P, Imbusch, Charles D, Brors, Benedikt, Benes, Vladimir, Jung, Birgit, Wyatt, David, Stahl, Heiko F, Plass, Christoph, Jurkowska, Renata Z

“…Patients with chronic obstructive pulmonary disease (COPD) are still waiting for curative treatments. Considering its environmental cause, we hypothesized that…”
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Modeling Pulmonary Disease Pathways Using Recombinant Adeno-Associated Virus 6.2 by Strobel, Benjamin, Duechs, Matthias J, Schmid, Ramona, Stierstorfer, Birgit E, Bucher, Hannes, Quast, Karsten, Stiller, Detlef, Hildebrandt, Tobias, Mennerich, Detlev, Gantner, Florian, Erb, Klaus J, Kreuz, Sebastian

“…Viral vectors have been applied successfully to generate disease-related animal models and to functionally characterize target genes in vivo. However, broader…”
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Dysregulation of club cell biology in idiopathic pulmonary fibrosis by Wu-Lin Zuo, Mahboubeh R. Rostami, Michelle LeBlanc, Robert J. Kaner, Sarah L. O’Beirne, Jason G. Mezey, Philip L. Leopold, Karsten Quast, Sudha Visvanathan, Jay S. Fine, Matthew J. Thomas, Ronald G. Crystal, Y. Peter Di

“…Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic fibrotic lung disease with an irreversible decline of lung function. “Bronchiolization”,…”
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