Search Results - "Karst, Alison"

Modeling high-grade serous ovarian carcinogenesis from the fallopian tube by Karst, Alison M, Levanon, Keren, Drapkin, Ronny

“…High-grade serous ovarian carcinoma (HGSOC) is a lethal disease for which improved screening and treatment strategies are urgently needed. Progress in these…”
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Primary culture and immortalization of human fallopian tube secretory epithelial cells by Karst, Alison M, Drapkin, Ronny

“…Primary human fallopian tube secretory epithelial cell (FTSEC) cultures are useful for studying normal fallopian tube epithelial biology, as well as for…”
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Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models by Perets, Ruth, Wyant, Gregory A., Muto, Katherine W., Bijron, Jonathan G., Poole, Barish B., Chin, Kenneth T., Chen, Jin Yun H., Ohman, Anders W., Stepule, Corey D., Kwak, Soongu, Karst, Alison M., Hirsch, Michelle S., Setlur, Sunita R., Crum, Christopher P., Dinulescu, Daniela M., Drapkin, Ronny

“…High-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges. Although the traditional model of carcinogenesis has focused on…”
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Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition by Au-Yeung, George, Lang, Franziska, Azar, Walid J, Mitchell, Chris, Jarman, Kate E, Lackovic, Kurt, Aziz, Diar, Cullinane, Carleen, Pearson, Richard B, Mileshkin, Linda, Rischin, Danny, Karst, Alison M, Drapkin, Ronny, Etemadmoghadam, Dariush, Bowtell, David D L

“…Cyclin E1 ( ) amplification is associated with primary treatment resistance and poor outcome in high-grade serous ovarian cancer (HGSC). Here, we explore…”
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Ovarian Cancer Pathogenesis : A Model in Evolution by Karst, Alison M., Drapkin, Ronny

“…Ovarian cancer is a deadly disease for which there is no effective means of early detection. Ovarian carcinomas comprise a diverse group of neoplasms,…”
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Cyclin E1 Deregulation Occurs Early in Secretory Cell Transformation to Promote Formation of Fallopian Tube-Derived High-Grade Serous Ovarian Cancers by KARST, Alison M, JONES, Paul M, VENA, Natalie, LIGON, Azra H, LIU, Joyce F, HIRSCH, Michelle S, ETEMADMOGHADAM, Dariush, BOWTELL, David D. L, DRAPKIN, Ronny

“…The fallopian tube is now generally considered the dominant site of origin for high-grade serous ovarian carcinoma. However, the molecular pathogenesis of…”
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Stathmin 1 and p16(INK4A) are sensitive adjunct biomarkers for serous tubal intraepithelial carcinoma by Novak, Marián, Lester, Jenny, Karst, Alison M, Parkash, Vinita, Hirsch, Michelle S, Crum, Christopher P, Karlan, Beth Y, Drapkin, Ronny

“…To credential Stathmin 1 (STMN1) and p16(INK4A) (p16) as adjunct markers for the diagnosis of serous tubal intraepithelial carcinoma (STIC), and to compare…”
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Stathmin 1, a marker of PI3K pathway activation and regulator of microtubule dynamics, is expressed in early pelvic serous carcinomas by Karst, Alison M, Levanon, Keren, Duraisamy, Sekhar, Liu, Joyce F, Hirsch, Michelle S, Hecht, Jonathan L, Drapkin, Ronny

“…Abstract Background Most high-grade pelvic serous carcinomas (HGPSCs) arise from fallopian tube epithelium (FTE). To date, few markers have been shown to…”
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Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4 by Ren, Yin, Cheung, Hiu Wing, von Maltzhan, Geoffrey, Agrawal, Amit, Cowley, Glenn S, Weir, Barbara A, Boehm, Jesse S, Tamayo, Pablo, Karst, Alison M, Liu, Joyce F, Hirsch, Michelle S, Mesirov, Jill P, Drapkin, Ronny, Root, David E, Lo, Justin, Fogal, Valentina, Ruoslahti, Erkki, Hahn, William C, Bhatia, Sangeeta N

“…The comprehensive characterization of a large number of cancer genomes will eventually lead to a compendium of genetic alterations in specific cancers…”
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Role of miR-182 in response to oxidative stress in the cell fate of human fallopian tube epithelial cells by Liu, Yugang, Qiang, Wenan, Xu, Xiaofei, Dong, Ruifen, Karst, Alison M, Liu, Zhaojian, Kong, Beihua, Drapkin, Ronny I, Wei, Jian-Jun

“…High grade serous ovarian carcinoma (HGSC) is a DNA instable tumor and its precursor is commonly found originating from the fimbriated end of the fallopian…”
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In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene by Dunn, Gavin P., Cheung, Hiu Wing, Agarwalla, Pankaj K., Thomas, Sapana, Zektser, Yulia, Karst, Alison M., Boehm, Jesse S., Weir, Barbara A., Berlin, Aaron M., Zou, Lihua, Getz, Gad, Liu, Joyce F., Hirsch, Michelle, Vazquez, Francisca, Root, David E., Beroukhim, Rameen, Drapkin, Ronny, Hahn, William C.

“…High-grade serous ovarian cancers are characterized by widespread recurrent copy number alterations. Although some regions of copy number change harbor known…”
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Nuclear factor kappa B subunit p50 promotes melanoma angiogenesis by upregulating interleukin‐6 expression by Karst, Alison M., Gao, Kai, Nelson, Colleen C., Li, Gang

“…Nuclear factor kappa B (NF‐κB) signaling is deregulated in many tumor types, resulting in aberrant expression and/or activation of NF‐κB transcriptional…”
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Stathmin 1 and p16INK4A are sensitive adjunct biomarkers for serous tubal intraepithelial carcinoma by Novak, Marián, Lester, Jenny, Karst, Alison M, Parkash, Vinita, Hirsch, Michelle S, Crum, Christopher P, Karlan, Beth Y, Drapkin, Ronny

“…Abstract Objective To credential Stathmin 1 (STMN1) and p16INK4A (p16) as adjunct markers for the diagnosis of serous tubal intraepithelial carcinoma (STIC),…”
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PUMA expression is significantly reduced in human cutaneous melanomas by KARST, Alison M, DAI, Derek L, MARTINKA, Magdalena, GANG LI

“…Cutaneous malignant melanoma is an aggressive form of skin cancer, characterized by strong chemoresistance and poor patient prognosis. The molecular mechanisms…”
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Role of p53 up-regulated modulator of apoptosis and phosphorylated akt in melanoma cell growth, apoptosis, and patient survival by KARST, Alison M, DAI, Derek L, CHENG, Jin Q, GANG LI

“…Malignant melanoma is an aggressive and chemoresistant form of skin cancer characterized by rapid metastasis and poor patient prognosis. The development of…”
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The new face of ovarian cancer modeling: better prospects for detection and treatment by Karst, Alison M, Drapkin, Ronny

“…Ovarian cancer has a disproportionately high mortality rate because patients typically present with late-stage metastatic disease. The vast majority of these…”
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Abstract PR01: Cyclin E: Targeting cell cycle dependencies in CCNE1-amplified tumors by Doberstein, Kai, Karst, Alison, Kroeger, Paul T., Jones, Paul, Hahn, William, Drapkin, Ronny

“…Abstract Genomic instability is a hallmark of high-grade serous ovarian carcinoma (HGSOC). Based on The Cancer Genome Atlas (TCGA), it is estimated that…”
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YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells by Hua, G, Lv, X, He, C, Remmenga, S W, Rodabough, K J, Dong, J, Yang, L, Lele, S M, Yang, P, Zhou, J, Karst, A, Drapkin, R I, Davis, J S, Wang, C

“…Accumulating evidence indicates that ovarian high-grade serous carcinoma (HGSC) originates from fallopian tube secretory epithelial cells (FTSECs). However,…”
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Abstract 1425: Targeting cell cycle dependencies in CCNE1 amplified tumors by Doberstein, Kai, Karst, Alison, Jones, Paul, Ligon, Azra, Hirsch, Michelle, Etemadmoghadam, Dariush, Hahn, William, Bowtell, David, Drapkin, Ronny

“…Abstract Genomic instability is a hallmark of high grade serous ovarian carcinoma (HGSOC). Based on The Cancer Genome Atlas (TCGA), it is estimated that…”
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Abstract PR05: Identifying potential targets in Cyclin E-amplified tumors by Doberstein, Kai, Karst, Alison, Etemadmoghadam, Dariush, Jones, Paul, Dunn, Gavin, Hahn, William, Bowtell, David, Drapkin, Ronny

“…Abstract Genomic instability is a hallmark of high grade serous ovarian carcinoma (HGSOC). Based on The Cancer Genome Atlas (TCGA), it is estimated that…”
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