Search Results - "Karsdal, M."

Osteoclast Activity and Subtypes as a Function of Physiology and Pathology???Implications for Future Treatments of Osteoporosis by Henriksen, K, Bollerslev, J, Everts, V, Karsdal, M. A

“…Osteoclasts are the sole cells capable of resorbing bone, and thus traditional strategies for osteoporosis have focused on eliminating these cells. However,…”
Get full text

Collagen‐mediated hemostasis by Manon‐Jensen, T., Kjeld, N. G., Karsdal, M. A.

“…Summary Collagens mediate essential hemostasis by maintaining the integrity and stability of the vascular wall. Imbalanced turnover of collagens by…”
Get full text

Clinical monitoring in osteoarthritis: Biomarkers by Kraus, V.B., Karsdal, M.A.

“…The purpose of this overview of osteoarthritis (OA) biomarkers is to provide the non-specialist with a toolbox, based on experience acquired by biomarker…”
Get full text

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments? by Karsdal, M A, Bay-Jensen, A C, Lories, R J, Abramson, S, Spector, T, Pastoureau, P, Christiansen, C, Attur, M, Henriksen, K, Goldring, S R, Kraus, V

“…Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of disability and impaired quality of life in the elderly. OA is a complex…”
Get more information

The good and the bad collagens of fibrosis – Their role in signaling and organ function by Karsdal, M.A., Nielsen, S.H., Leeming, D.J., Langholm, L.L., Nielsen, M.J., Manon-Jensen, T., Siebuhr, A., Gudmann, N.S., Rønnow, S., Sand, J.M., Daniels, S.J., Mortensen, J.H., Schuppan, D.

“…Usually the dense extracellular structure in fibrotic tissues is described as extracellular matrix (ECM) or simply as collagen. However, fibrosis is not just…”
Get full text

Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis by Jessen, H, Hoyer, N, Prior, T S, Frederiksen, P, Karsdal, M A, Leeming, D J, Bendstrup, E, Sand, J M B, Shaker, S B

“…Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of fibrillar collagens in the alveolar space resulting in reduced pulmonary function…”
Get full text

Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use by Kraus, V.B, Blanco, F.J, Englund, M, Karsdal, M.A, Lohmander, L.S

“…Summary Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for OA that could serve…”
Get full text

Excessive collagen turnover products are released during colorectal cancer progression and elevated in serum from metastatic colorectal cancer patients by Kehlet, S. N., Sanz-Pamplona, R., Brix, S., Leeming, D. J., Karsdal, M. A., Moreno, V.

“…During cancer progression, the homeostasis of the extracellular matrix becomes imbalanced with an excessive collagen remodeling by matrix metalloproteinases…”
Get full text

Novel serological neo‐epitope markers of extracellular matrix proteins for the detection of portal hypertension by Leeming, D. J., Karsdal, M. A., Byrjalsen, I., Bendtsen, F., Trebicka, J., Nielsen, M. J., Christiansen, C., Møller, S., Krag, A.

“…Summary Background The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal…”
Get full text

Does receptor balance matter? – Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models by Larsen, A.T., Mohamed, K.E., Sonne, N., Bredtoft, E., Andersen, F., Karsdal, MA, Henriksen, K.

“…Cagrilintide is a novel long-acting amylin receptor agonist, which has shown a potent induction of weight loss. Interestingly, cagrilintide is a Dual Amylin…”
Get full text

Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis by Leeming, D J, Genovese, F, Sand, J M B, Rasmussen, D G K, Christiansen, C, Jenkins, G, Maher, T M, Vestbo, J, Karsdal, M A

“…Pulmonary fibrosis has been identified as a main factor leading to pulmonary dysfunction and poor quality of life in post-recovery Severe Acute Respiratory…”
Get full text

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future by Karsdal, M.A, Michaelis, M, Ladel, C, Siebuhr, A.S, Bihlet, A.R, Andersen, J.R, Guehring, H, Christiansen, C, Bay-Jensen, A.C, Kraus, V.B

“…Summary Osteoarthritis (OA) is the biggest unmet medical need among the many musculoskeletal conditions and the most common form of arthritis. It is a major…”
Get full text

A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen by Barascuk, N., Veidal, S.S., Larsen, L., Larsen, D.V., Larsen, M.R., Wang, J., Zheng, Q., Xing, R., Cao, Y., Rasmussen, L.M., Karsdal, M.A.

“…Accumulation of extracellular matrix (ECM) components and increased matrix-metalloprotease (MMPs) activity are hallmarks of fibrosis. We developed an ELISA for…”
Get full text

Review article: the efficacy of biomarkers in chronic fibroproliferative diseases – early diagnosis and prognosis, with liver fibrosis as an exemplar by Karsdal, M. A., Krarup, H., Sand, J. M. B., Christensen, P. B., Gerstoft, J., Leeming, D. J., Weis, N., Schaffalitzky de Muckadell, O. B., Krag, A.

“…Summary Background Nearly 45% of all deaths are associated with chronic fibroproliferative diseases, of which the primary characteristic is altered remodelling…”
Get full text

Value of biomarkers in osteoarthritis: current status and perspectives by Lotz, M, Martel-Pelletier, J, Christiansen, C, Brandi, M-L, Bruyère, O, Chapurlat, R, Collette, J, Cooper, C, Giacovelli, G, Kanis, J A, Karsdal, M A, Kraus, V, Lems, W F, Meulenbelt, I, Pelletier, J-P, Raynauld, J-P, Reiter-Niesert, S, Rizzoli, R, Sandell, L J, Van Spil, W E, Reginster, J-Y

“…Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation…”
Get more information

Proposed study designs for approval based on a surrogate endpoint and a post-marketing confirmatory study under FDA's accelerated approval regulations for disease modifying osteoarthritis drugs by Kraus, V.B., Simon, L.S., Katz, J.N., Neogi, T., Hunter, D., Guermazi, A., Karsdal, M.A.

“…In 1992, the Food and Drug Administration (FDA) instituted the accelerated approval regulations that allow drugs or biologics for serious conditions that fill…”
Get full text

Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix by Gigout, A., Guehring, H., Froemel, D., Meurer, A., Ladel, C., Reker, D., Bay-Jensen, A.C., Karsdal, M.A., Lindemann, S.

“…Fibroblast growth factor (FGF) 18 has been shown to increase cartilage volume when injected intra-articularly in animal models of osteoarthritis (OA) and in…”
Get full text

Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials by Karsdal, M.A, Byrjalsen, I, Alexandersen, P, Bihlet, A, Andersen, J.R, Riis, B.J, Bay-Jensen, A.C, Christiansen, C

“…Summary Purpose To evaluate the structure-modifying and symptom efficacy, as well as safety and tolerability of oral salmon calcitonin (sCT) formulated with a…”
Get full text

Identification of pathological RA endotypes using blood-based biomarkers reflecting tissue metabolism. A retrospective and explorative analysis of two phase III RA studies by Blair, J P M, Bager, C, Platt, A, Karsdal, M, Bay-Jensen, A-C

“…There is an increasing demand for accurate endotyping of patients according to their pathogenesis to allow more targeted treatment. We explore a combination of…”
Get full text

Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease by Haaften, W. T., Mortensen, J. H., Karsdal, M. A., Bay‐Jensen, A. C., Dijkstra, G., Olinga, P.

“…Summary Background Misbalances in extracellular matrix turnover are key factors in the development of stricturing (Montreal B2) and penetrating (Montreal B3)…”
Get full text