Search Results - "Karr, Timothy"

Sperm Proteome Maturation in the Mouse Epididymis by Skerget, Sheri, Rosenow, Matthew A, Petritis, Konstantinos, Karr, Timothy L

“…In mammals, transit through the epididymis, which involves the acquisition, loss and modification of proteins, is required to confer motility and fertilization…”
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Reproductive Proteomics Comes of Age by Karr, Timothy L.

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Stage-specific expression profiling of Drosophila spermatogenesis suggests that meiotic sex chromosome inactivation drives genomic relocation of testis-expressed genes by Vibranovski, Maria D, Lopes, Hedibert F, Karr, Timothy L, Long, Manyuan

“…In Drosophila, genes expressed in males tend to accumulate on autosomes and are underrepresented on the X chromosome. In particular, genes expressed in testis…”
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Functional Diversity and Evolution of the Drosophila Sperm Proteome by Garlovsky, Martin D., Sandler, Jessica A., Karr, Timothy L.

“…Spermatozoa are central to fertilization and the evolutionary fitness of sexually reproducing organisms. As such, a deeper understanding of sperm proteomes…”
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The Seminal fluid proteome of the polyandrous Red junglefowl offers insights into the molecular basis of fertility, reproductive ageing and domestication by Borziak, Kirill, Álvarez-Fernández, Aitor, L. Karr, Timothy, Pizzari, Tommaso, Dorus, Steve

“…Seminal fluid proteins (SFPs) are emerging as fundamental contributors to sexual selection given their role in post-mating reproductive events, particularly in…”
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Seminal fluid protein divergence among populations exhibiting postmating prezygotic reproductive isolation by Garlovsky, Martin D., Evans, Caroline, Rosenow, Mathew A., Karr, Timothy L., Snook, Rhonda R.

“…Despite holding a central role in fertilization, reproductive traits often show elevated rates of evolution and diversification. The rapid evolution of seminal…”
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The Rhesus Macaque (Macaca mulatta) Sperm Proteome by Skerget, Sheri, Rosenow, Matthew, Polpitiya, Ashoka, Petritis, Konstantinos, Dorus, Steve, Karr, Timothy L.

“…Mass spectrometry based proteomics has facilitated sperm composition studies in several mammalian species but no studies have been undertaken in non-human…”
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Genomic and functional evolution of the Drosophila melanogaster sperm proteome by Karr, Timothy L, Dorus, Steve, Busby, Scott A, Gerike, Ursula, Shabanowitz, Jeffrey, Hunt, Donald F

“…In addition to delivering a haploid genome to the egg, sperm have additional critical functions, including egg activation, origination of the zygote centrosome…”
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The Drosophila Neprilysin 4 gene is essential for sperm function following sperm transfer to females by Ohsako, Takashi, Shirakami, Machi, Oiwa, Kazuharu, Ibaraki, Kimihide, Karr, Timothy L., Tomaru, Masatoshi, Sanuki, Rikako, Takano-Shimizu-Kouno, Toshiyuki

“…Sperm are modified substantially in passing through both the male and the female reproductive tracts, only thereafter becoming functionally competent to…”
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Identification and characterization of the zebra finch (Taeniopygia guttata) sperm proteome by Rowe, Melissah, Skerget, Sheri, Rosenow, Matthew A., Karr, Timothy L.

“…Spermatozoa exhibit remarkable variability in size, shape, and performance. Our understanding of the molecular basis of this variation, however, is limited,…”
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The biology and evolution of polyspermy: insights from cellular and functional studies of sperm and centrosomal behavior in the fertilized egg by Snook, Rhonda R, Hosken, David J, Karr, Timothy L

“…Recent studies of centrosome biogenesis, microtubule dynamics, and their management point to their role in mediating conditions such as aging and cancer…”
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Comparative Sperm Proteomics in Mouse Species with Divergent Mating Systems by Vicens, Alberto, Borziak, Kirill, Karr, Timothy L, Roldan, Eduardo R S, Dorus, Steve

“…Sexual selection is the pervasive force underlying the dramatic divergence of sperm form and function. Although it has been demonstrated that testis gene…”
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The Old and the New: Discovery Proteomics Identifies Putative Novel Seminal Fluid Proteins in Drosophila by Karr, Timothy L., Southern, Helen, Rosenow, Matthew A., Gossmann, Toni I., Snook, Rhonda R.

“…We used discovery, bottom up proteomics to provide the first in-depth accessory gland proteome in D. pseudoobscura,. Computational bioinformatics identified…”
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Single cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease by Wang, Qi, Antone, Jerry, Alsop, Eric, Reiman, Rebecca, Funk, Cory, Bendl, Jaroslav, Dudley, Joel T., Liang, Winnie S., Karr, Timothy L., Roussos, Panos, Bennett, David A., De Jager, Philip L., Serrano, Geidy E., Beach, Thomas G., Van Keuren-Jensen, Kendall, Mastroeni, Diego, Reiman, Eric M., Readhead, Benjamin P.

“…The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the study of Alzheimer’s disease (AD). Integration with complementary…”
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Humanization and expression of IgG and IgM antibodies in plants as potential diagnostic reagents for Valley Fever by Jugler, Collin, Grill, Francisca J, Eidenberger, Lukas, Karr, Timothy L, Grys, Thomas E, Steinkellner, Herta, Lake, Douglas F, Chen, Qiang

“…Monoclonal antibodies (mAbs) are important proteins used in many life science applications, from diagnostics to therapeutics. High demand for mAbs for…”
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Contrasting patterns of evolutionary constraint and novelty revealed by comparative sperm proteomic analysis in Lepidoptera by Whittington, Emma, Forsythe, Desiree, Borziak, Kirill, Karr, Timothy L, Walters, James R, Dorus, Steve

“…Rapid evolution is a hallmark of reproductive genetic systems and arises through the combined processes of sequence divergence, gene gain and loss, and changes…”
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Sperm proteomics reveals intensified selection on mouse sperm membrane and acrosome genes by Dorus, Steve, Wasbrough, Elizabeth R, Busby, Jennifer, Wilkin, Elaine C, Karr, Timothy L

“…Spermatozoa are a focal point for the impact of sexual selection due to sperm competition and sperm-female interactions in a wide range of sexually reproducing…”
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Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm by Dorus, Steve, Wilkin, Elaine C, Karr, Timothy L

“…The evolutionary diversification of gene families through gene creation (and loss) is a dynamic process believed to be critical to the evolution of functional…”
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The histone H3.3 chaperone HIRA is essential for chromatin assembly in the male pronucleus by Anselme, Caroline, Couble, Pierre, Laurençon, Anne, Bonnefoy, Emilie, Loppin, Benjamin, Karr, Timothy L

“…In sexually reproducing animals, a crucial step in zygote formation is the decondensation of the fertilizing sperm nucleus into a DNA replication-competent…”
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The Drosophila melanogaster sperm proteome-II (DmSP-II) by Wasbrough, Elizabeth R., Dorus, Steve, Hester, Svenja, Howard-Murkin, Julie, Lilley, Kathryn, Wilkin, Elaine, Polpitiya, Ashoka, Petritis, Konstantinos, Karr, Timothy L.

“…Advances in mass spectrometry technology, high-throughput proteomics and genome annotations have resulted in significant increases in our molecular…”
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