Search Results - "Karponi, Garyfalia"

Development of a CRISPR/Cas9 system against ruminant animal brucellosis by Karponi, Garyfalia, Kritas, Spyridon K, Papadopoulou, Gina, Akrioti, Elissavet-Kalliopi, Papanikolaou, Eleni, Petridou, Evanthia

“…Brucellosis, caused by several Brucella species, such as the bacterium Brucella melitensis, is considered one of the most severe zoonotic diseases worldwide…”
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Efficient Transduction and Expansion of Ovine Macrophages for Gene Therapy Implementations by Karponi, Garyfalia, Kritas, Spyridon, Petridou, Evanthia, Papanikolaou, Eleni

“…A number of bacteria provoking zoonotic diseases present intracellular survival and a host cell tropism limited to the monocyte/macrophage lineage. Thus,…”
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A Cellular Model of Infection with Brucella melitensis in Ovine Macrophages: Novel Insights for Intracellular Bacterial Detection by Karponi, Garyfalia, Kritas, Spyridon K, Papanikolaou, Eleni, Petridou, Evanthia

“…Intracellular bacteria provoking zoonoses, such as those of the genus , present a host cell tropism mostly limited to the monocyte/macrophage lineage, leading…”
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Current Status and Developments in Gene Therapy for Thalassemia and Sickle Cell Disease by Yannaki, Evangelia, Karponi, Garyfalia

“…β-thalassemias and sickle cell anemia (SCA) are the most common monogenic diseases worldwide for which curative treatments remain a desired goal. Allogeneic…”
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Optimizing autologous cell grafts to improve stem cell gene therapy by Psatha, Nikoletta, Karponi, Garyfalia, Yannaki, Evangelia

“…Over the past decade, stem cell gene therapy has achieved unprecedented curative outcomes for several genetic disorders. Despite the unequivocal success,…”
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Gene Therapy For Beta-Thalassemia: Updated Perspectives by Karponi, Garyfalia, Zogas, Nikolaos

“…Allogeneic hematopoietic stem cell transplantation was until very recently, the only permanent curative option available for patients suffering from…”
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Plerixafor+G-CSF–mobilized CD34+ cells represent an optimal graft source for thalassemia gene therapy by Karponi, Garyfalia, Psatha, Nikoletta, Lederer, Carsten Werner, Adair, Jennifer Eileen, Zervou, Fani, Zogas, Nikolaos, Kleanthous, Marina, Tsatalas, Constantinos, Anagnostopoulos, Achilles, Sadelain, Michel, Rivière, Isabelle, Stamatoyannopoulos, George, Yannaki, Evangelia

“…Globin gene therapy requires abundant numbers of highly engraftable, autologous hematopoietic stem cells expressing curative levels of β-globin on…”
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Safe mobilization of CD34+ cells in adults with β-thalassemia and validation of effective globin gene transfer for clinical investigation by Boulad, Farid, Wang, Xiuyan, Qu, Jinrong, Taylor, Clare, Ferro, Leda, Karponi, Garyfalia, Bartido, Shirley, Giardina, Patricia, Heller, Glenn, Prockop, Susan E., Maggio, Aurelio, Sadelain, Michel, Rivière, Isabelle

“…We conducted a pilot trial to investigate the safety and effectiveness of mobilizing CD34+ hematopoietic progenitor cells (HPCs) in adults with β-thalassemia…”
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Hematopoietic stem cell mobilization for gene therapy: superior mobilization by the combination of granulocyte-colony stimulating factor plus plerixafor in patients with β-thalassemia major by Yannaki, Evangelia, Karponi, Garyfalia, Zervou, Fani, Constantinou, Varnavas, Bouinta, Asimina, Tachynopoulou, Varvara, Kotta, Konstantina, Jonlin, Erica, Papayannopoulou, Thalia, Anagnostopoulos, Achilles, Stamatoyannopoulos, George

“…Successful stem cell gene therapy requires high numbers of genetically engineered hematopoietic stem cells collected using optimal mobilization strategies…”
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Poor stem cell harvest may not always be related to poor mobilization: lessons gained from a mobilization study in patients with β‐thalassemia major by Constantinou, Varnavas C., Bouinta, Asimina, Karponi, Garyfalia, Zervou, Fani, Papayanni, Penelope‐Georgia, Stamatoyannopoulos, George, Anagnostopoulos, Achilles, Yannaki, Evangelia

“…BACKGROUND Hematopoietic stem cell mobilization and leukapheresis in adult patients with β‐thalassemia have recently been optimized in the context of clinical…”
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291. CD26 Inhibition Enhances Chimerism of Lentivirally Transduced Hematopoietic Stem Cells in a Non-Myeloablative Setting by Karponi, Garyfalia, Georgakopoulou, Afroditi, Sgouramalli, Eleni, Rantoglou, Eirini, Soufleros, Loudovikos, Anagnostopoulos, Achilles, Yannaki, Evangelia

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Poor stem cell harvest may not always be related to poor mobilization: lessons gained from a mobilization study in patients with [beta]-thalassemia major by Constantinou, Varnavas C, Bouinta, Asimina, Karponi, Garyfalia, Zervou, Fani, Papayanni, Penelope-Georgia, Stamatoyannopoulos, George, Anagnostopoulos, Achilles, Yannaki, Evangelia

“…BACKGROUND Hematopoietic stem cell mobilization and leukapheresis in adult patients with [beta]-thalassemia have recently been optimized in the context of…”
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The ex vivo toll-like receptor 7 tolerance induction in donor lymphocytes prevents murine acute graft-versus-host disease by Zogas, Nikolaos, Karponi, Garyfalia, Iordanidis, Fotios, Malasidis, Stylianos, Paraskevas, Vasilios, Papadopoulou, Anastasia, Scouras, Zaharias George, Anagnostopoulos, Achilles, Yannaki, Evangelia

“…•The ex vivo–induced TLR7 tolerance in T cells provides a striking anti-aGVHD effect.•The TLR7 ligand–mediated tolerance induces functional regulatory T cells…”
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Hematopoietic Stem Cell Mobilization for Gene Therapy of Adult Patients With Severe β-Thalassemia: Results of Clinical Trials Using G-CSF or Plerixafor in Splenectomized and Nonsplenectomized Subjects by Yannaki, Evangelia, Papayannopoulou, Thalia, Jonlin, Erica, Zervou, Fani, Karponi, Garyfalia, Xagorari, Angeliki, Becker, Pamela, Psatha, Nikoleta, Batsis, Ioannis, Kaloyannidis, Panayotis, Tahynopoulou, Varvara, Constantinou, Varnavas, Bouinta, Asimina, Kotta, Konstantia, Athanassiadou, Aglaia, Anagnostopoulos, Achilles, Fassas, Athanasios, Stamatoyannopoulos, George

“…The safety and efficacy of hematopoietic stem cell (HSC) mobilization was investigated in adult splenectomized (SPL) and non-SPL patients with thalassemia…”
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Poor stem cell harvest may not always be related to poor mobilization: lessons gained from a mobilization study in beta-thalassemia major patients by Constantinou, Varnavas C., Bouinta, Asimina, Karponi, Garyfalia, Zervou, Fani, Papayanni, Penelope-Georgia, Stamatoyannopoulos, George, Anagnostopoulos, Achilles, Yannaki, Evangelia

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The Functional Effect of Repeated Cryopreservation on Transduced CD34 + Cells from Patients with Thalassemia by Karponi, Garyfalia, Papayanni, Penelope-Georgia, Zervou, Fani, Bouinta, Asimina, Anagnostopoulos, Achilles, Yannaki, Evangelia

“…Stable gene marking and effective engraftment of gene-modified CD34 hematopoietic stem cells is a prerequisite for gene therapy success but may be challenged…”
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The Ex-Vivo Tolerance Induction To TLR7 In Donor Lymphocytes Prevents aGvHD In a Mismatched Transplantation Mouse Model by Zogas, Nikolaos, Malasidis, Stylianos, Iordanidis, Fotios, Karponi, Garyfalia, Tsolaki, Eleftheria, Scouras, Zaharias, Anagnostopoulos, Achilles, Yannaki, Evangelia

“…Acute Graft vs Host Disease (aGvHD) is the major cause of non-relapse mortality after allogeneic stem cell transplantation limiting the effectiveness of this…”
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A Tribute to George Stamatoyannopoulos by Srivastava, Arun, Kay, Mark A, Athanasopoulos, Takis, Angastiniotis, Michael, Anagnostopoulos, Achilles, Karponi, Garyfalia, Yannaki, Evangelia, Zon, Leonard I, Lederer, Carsten W, Phylactides, Marios S, Kleanthous, Marina

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In vivo selection of autologous MGMT gene-modified cells following reduced-intensity conditioning with BCNU and temozolomide in the dog model by Gori, J L, Beard, B C, Ironside, C, Karponi, G, Kiem, H-P

“…Chemotherapy with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) and temozolomide (TMZ) is commonly used for the treatment of glioblastoma multiforme (GBM) and…”
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Hematopoietic Cell Mobilization for Gene Therapy of Adult Patients with Severe Beta-Thalassemia: The Challenge of Splenectomy and the Role of Plerixafor by Yannaki, Evangelia, Papayannopoulou, Thalia, Jonlin, Erica, Zervou, Fani, Karponi, Garyfalia, Xagorari, Angeliki, Becker, Pamela S., Psatha, Nikoleta, Batsis, Ioannis, Kaloyannidis, Panayotis, Tahynopoulou, Varvara, Constantinou, Varnavas, Bouinta, Asimenia, Kotta, Konstantia, Athanassiadou, Aglaia, Anagnostopoulos, Achilles, Fassas, Athanasios, Stamatoyannopoulos, George

“…Abstract 166▪FN2▪This icon denotes a clinically relevant abstract In preparation for a trial for gene therapy of thalassemia, we investigated the safety and…”
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