Search Results - "Karplus, P A"

Better models by discarding data? by Diederichs, K., Karplus, P. A.

“…In macromolecular X‐ray crystallography, typical data sets have substantial multiplicity. This can be used to calculate the consistency of repeated…”
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Typical 2-Cys peroxiredoxins - structures, mechanisms and functions by Hall, Andrea, Karplus, P.A, Poole, Leslie B

“…Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part,…”
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Experimentally observed conformation‐dependent geometry and hidden strain in proteins by Karplus, P. Andrew

“…A database has been compiled documenting the peptide conformations and geometries from 70 diverse proteins refined at 1.75 Å or better. Analysis of the…”
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Glutathione Reductase of the Malarial Parasite Plasmodium falciparum: Crystal Structure and Inhibitor Development by Sarma, G.N., Savvides, S.N., Becker, K., Schirmer, M., Schirmer, R.H., Karplus, P.A.

“…The malarial parasite Plasmodium falciparum is known to be sensitive to oxidative stress, and thus the antioxidant enzyme glutathione reductase (GR;…”
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The Crystal Structure of Urease from Klebsiella aerogenes by Jabri, Evelyn, Carr, Mary Beth, Hausinger, Robert P., Karplus, P. Andrew

“…The crystal structure of urease from Klebsiella aerogenes has been determined at 2.2 $\angst $ resolution and refined to an R factor of 18.2 percent. The…”
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Hydrophobicity regained by Andrew Karplus, P.

“…A widespread practice is to use free energies of transfer between organic solvents and water (ΔGtransfer°) to define hydrophobicity scales for the amino acid…”
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Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin by Van Duyne, G D, Standaert, R F, Karplus, P A, Schreiber, S L, Clardy, J

“…High resolution structures for the complexes formed by the immunosuppressive agents FK506 and rapamycin with the human immunophilin FKBP-12 have been…”
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Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex by Van Duyne, Gregory D., Standaert, Robert F., Karplus, P. Andrew, Schreiber, Stuart L., Clardy, Jon

“…The structure of the human FK506 binding protein (FKBP), complexed with the immunosuppressant FK506, has been determined to 1.7 angstroms resolution by x-ray…”
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Molecular Dynamics Studies of the Hydration of α,α-Trehalose by Liu, Qiang, Schmidt, R. K, Teo, B, Karplus, P. A, Brady, J. W

“…Molecular dynamics simulations have been used to model the aqueous solvation of the nonreducing sugar α,α-trehalose. The anisotropic structuring of water…”
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Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase by Ponasik, J A, Strickland, C, Faerman, C, Savvides, S, Karplus, P A, Ganem, B

“…The enzyme trypanothione reductase (TR), together with its substrate, the glutathione-spermidine conjugate trypanothione, plays an essential role in protecting…”
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Atomic Structure of Ferredoxin-NADP$^ $ Reductase: Prototype for a Structurally Novel Flavoenzyme Family by Karplus, P. Andrew, Daniels, Mark J., Herriott, Jon R.

“…The three-dimensional structure of spinach ferredoxin-NADP$^ $ reductase (NADP$^ $, nicotinamide adenine dinucleotide phosphate) has been determined by x-ray…”
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Crystal structure of the catalytic domain of a thermophilic endocellulase by Spezio, Michael, Wilson, David B, Karplus, P. Andrew

“…One way to improve the economic feasibility of biomass conversion is to enhance the catalytic efficiency of cellulases through protein engineering. This…”
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Structure of Intact AhpF Reveals a Mirrored Thioredoxin-like Active Site and Implies Large Domain Rotations during Catalysis by Wood, Zachary A, Poole, Leslie B, Karplus, P. Andrew

“…AhpF, a homodimer of 57 kDa subunits, is a flavoenzyme which catalyzes the NADH-dependent reduction of redox-active disulfide bonds in the peroxidase AhpC, a…”
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Biochemical and Crystallographic Characterization of Ferredoxin−NADP+ Reductase from Nonphotosynthetic Tissues by Aliverti, Alessandro, Faber, Rick, Finnerty, Casey M, Ferioli, Cristian, Pandini, Vittorio, Negri, Armando, Karplus, P. Andrew, Zanetti, Giuliana

“…Distinct forms of ferredoxin−NADP+ reductase are expressed in photosynthetic and nonphotosynthetic plant tissues. Both enzymes catalyze electron transfer…”
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Structural prototypes for an extended family of flavoprotein reductases: Comparison of phthalate dioxygenase reductase with ferredoxin reductase and ferredoxin by Correll, Carl C., Ludwig, Martha L., Bruns, Christopher M., Karplus, P. Andrew

“…The structure of phthalate dioxygenase reductase (PDR), a monomeric iron‐sulfur flavoprotein that delivers electrons from NADH to phthalate dioxygenase, is…”
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Structure of the ERM Protein Moesin Reveals the FERM Domain Fold Masked by an Extended Actin Binding Tail Domain by Pearson, Matthew A., Reczek, David, Bretscher, Anthony, Karplus, P.Andrew

“…The ezrin-radixin-moesin (ERM) protein family link actin filaments of cell surface structures to the plasma membrane, using a C-terminal F-actin binding…”
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A productive NADP + binding mode of ferredoxin-NADP + reductase revealed by protein engineering and crystallographic studies by Karplus, P. Andrew, Deng, Zhan, Aliverti, Alessandro, Zanetti, Giuliana, Arakaki, Adrián K, Ottado, Jorgelina, Orellano, Elena G, Calcaterra, Nora B, Ceccarelli, Eduardo A, Carrillo, Néstor

“…The flavoenzyme ferredoxin-NADP+ reductase (FNR) catalyzes the production of NADPH during photosynthesis. Whereas the structures of FNRs from spinach leaf and…”
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Characterization of metal-substituted Klebsiella aerogenes urease by Yamaguchi, K, Cosper, N J, Stålhandske, C, Scott, R A, Pearson, M A, Karplus, P A, Hausinger, R P

“…Urease possesses a dinuclear Ni active site with the protein providing a bridging carbamylated lysine residue as well as an aspartyl and four histidyl ligands…”
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The insect immune protein scolexin is a novel serine proteinase homolog by FINNERTY, CASEY M., KARPLUS, P. ANDREW, GRANADOS, ROBERT R.

“…Scolexin is a coagulation-provoking plasma protein induced in response to bacterial or viral infection of larval Manduca sexta, a large lepidopterous insect…”
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Hematopoietic Growth Factors: Understanding Functional Diversity in Structural Terms by Kaushansky, Kenneth, Karplus, P. Andrew

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