Search Results - "Karpenko, Larisa I"

The use of electroporation to deliver DNA-based vaccines by Belyakov, Igor M, Kisakov, Denis N, Kisakova, Lubov A, Yakovlev, Vladimir A, Tigeeva, Elena V, Karpenko, Larisa I

“…Nucleic acids represent a promising platform for creating vaccines, including against COVID-19. One disadvantage of this approach is its relatively low…”
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Dendrimer-Mediated Delivery of DNA and RNA Vaccines by Kisakova, Lyubov A, Apartsin, Evgeny K, Nizolenko, Lily F, Karpenko, Larisa I

“…DNA and RNA vaccines (nucleic acid-based vaccines) are a promising platform for vaccine development. The first mRNA vaccines (Moderna and Pfizer/BioNTech) were…”
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Synthesis and In Vitro Study of Antiviral Activity of Glycyrrhizin Nicotinate Derivatives against HIV-1 Pseudoviruses and SARS-CoV-2 Viruses by Fomenko, Vladislav V, Rudometova, Nadezhda B, Yarovaya, Olga I, Rogachev, Artem D, Fando, Anastasia A, Zaykovskaya, Anna V, Komarova, Nina I, Shcherbakov, Dmitry N, Pyankov, Oleg V, Pokrovsky, Andrey G, Karpenko, Larisa I, Maksyutov, Rinat A, Salakhutdinov, Nariman F

“…When developing drugs against SARS-CoV-2, it is important to consider the characteristics of patients with different co-morbidities. People infected with HIV-1…”
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Self-Assembled Particles Combining SARS-CoV-2 RBD Protein and RBD DNA Vaccine Induce Synergistic Enhancement of the Humoral Response in Mice by Borgoyakova, Mariya B, Karpenko, Larisa I, Rudometov, Andrey P, Volosnikova, Ekaterina A, Merkuleva, Iuliia A, Starostina, Ekaterina V, Zadorozhny, Alexey M, Isaeva, Anastasiya A, Nesmeyanova, Valentina S, Shanshin, Daniil V, Baranov, Konstantin O, Volkova, Natalya V, Zaitsev, Boris N, Orlova, Lyubov A, Zaykovskaya, Anna V, Pyankov, Oleg V, Danilenko, Elena D, Bazhan, Sergei I, Shcherbakov, Dmitry N, Taranin, Alexander V, Ilyichev, Alexander A

“…Despite the fact that a range of vaccines against COVID-19 have already been created and are used for mass vaccination, the development of effective, safe,…”
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Enhancing the Immunogenicity of Vaccinia Virus by Shchelkunov, Sergei N, Yakubitskiy, Stanislav N, Sergeev, Alexander A, Starostina, Ekaterina V, Titova, Ksenia A, Pyankov, Stepan A, Shchelkunova, Galina A, Borgoyakova, Mariya B, Zadorozhny, Alexey M, Orlova, Lyubov A, Kisakov, Denis N, Karpenko, Larisa I

“…The conventional live smallpox vaccine based on the vaccinia virus (VACV) cannot be widely used today because it is highly reactogenic. Therefore, there is a…”
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In silico Designed Ebola Virus T-Cell Multi-Epitope DNA Vaccine Constructions Are Immunogenic in Mice by Bazhan, Sergei I, Antonets, Denis V, Karpenko, Larisa I, Oreshkova, Svetlana F, Kaplina, Olga N, Starostina, Ekaterina V, Dudko, Sergei G, Fedotova, Sofia A, Ilyichev, Alexander A

“…: The lack of effective vaccines against Ebola virus initiates a search for new approaches to overcoming this problem. The aim of the study was to design…”
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Comparative Immunogenicity of the Recombinant Receptor-Binding Domain of Protein S SARS-CoV-2 Obtained in Prokaryotic and Mammalian Expression Systems by Merkuleva, Iuliia A, Shcherbakov, Dmitry N, Borgoyakova, Mariya B, Shanshin, Daniil V, Rudometov, Andrey P, Karpenko, Larisa I, Belenkaya, Svetlana V, Isaeva, Anastasiya A, Nesmeyanova, Valentina S, Kazachinskaia, Elena I, Volosnikova, Ekaterina A, Esina, Tatiana I, Zaykovskaya, Anna V, Pyankov, Oleg V, Borisevich, Sophia S, Shelemba, Arseniya A, Chikaev, Anton N, Ilyichev, Alexander A

“…The receptor-binding domain (RBD) of the protein S SARS-CoV-2 is considered to be one of the appealing targets for developing a vaccine against COVID-19. The…”
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Adaptive Immune Response to Vaccinia Virus LIVP Infection of BALB/c Mice and Protection against Lethal Reinfection with Cowpox Virus by Shchelkunov, Sergei N, Sergeev, Alexander A, Yakubitskiy, Stanislav N, Titova, Ksenia A, Pyankov, Stepan A, Kolosova, Irina V, Starostina, Ekaterina V, Borgoyakova, Mariya B, Zadorozhny, Alexey M, Kisakov, Denis N, Shulgina, Irina S, Karpenko, Larisa I

“…Mass vaccination has played a critical role in the global eradication of smallpox. Various vaccinia virus (VACV) strains, whose origin has not been clearly…”
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Delivery of mRNA Vaccine against SARS-CoV-2 Using a Polyglucin:Spermidine Conjugate by Karpenko, Larisa I, Rudometov, Andrey P, Sharabrin, Sergei V, Shcherbakov, Dmitry N, Borgoyakova, Mariya B, Bazhan, Sergei I, Volosnikova, Ekaterina A, Rudometova, Nadezhda B, Orlova, Lyubov A, Pyshnaya, Inna A, Zaitsev, Boris N, Volkova, Natalya V, Azaev, Mamedyar Sh, Zaykovskaya, Anna V, Pyankov, Oleg V, Ilyichev, Alexander A

“…One of the key stages in the development of mRNA vaccines is their delivery. Along with liposome, other materials are being developed for mRNA delivery that…”
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Cationic Polymers for the Delivery of the Ebola DNA Vaccine Encoding Artificial T-Cell Immunogen by Karpenko, Larisa I, Apartsin, Evgeny K, Dudko, Sergei G, Starostina, Ekaterina V, Kaplina, Olga N, Antonets, Denis V, Volosnikova, Ekaterina A, Zaitsev, Boris N, Bakulina, Anastasiya Yu, Venyaminova, Aliya G, Ilyichev, Alexander A, Bazhan, Sergei I

“…According to current data, an effective Ebola virus vaccine should induce both humoral and T-cell immunity. In this work, we focused our efforts on methods for…”
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Immunogenicity and Protective Efficacy of a Single Intranasal Dose Vectored Vaccine Based on Sendai Virus (Moscow Strain) against SARS-CoV-2 Variant of Concern by Kochneva, Galina V, Kudrov, Gleb A, Zainutdinov, Sergei S, Shulgina, Irina S, Shipovalov, Andrei V, Zaykovskaya, Anna V, Borgoyakova, Mariya B, Starostina, Ekaterina V, Bodnev, Sergei A, Sivolobova, Galina F, Grazhdantseva, Antonina A, Ivkina, Daria I, Zadorozhny, Alexey M, Karpenko, Larisa I, P'yankov, Oleg V

“…The mouse paramyxovirus Sendai, which is capable of limited replication in human bronchial epithelial cells without causing disease, is well suited for the…”
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Selection of peptide mimics of HIV-1 epitope recognized by neutralizing antibody VRC01 by Chikaev, Anton N, Bakulina, Anastasiya Yu, Burdick, Ryan C, Karpenko, Larisa I, Pathak, Vinay K, Ilyichev, Alexander A

“…The ability to induce anti-HIV-1 antibodies that can neutralize a broad spectrum of viral isolates from different subtypes seems to be a key requirement for…”
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Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus by Rudometova, Nadezhda B, Fando, Anastasia A, Kisakova, Lyubov A, Kisakov, Denis N, Borgoyakova, Mariya B, Litvinova, Victoria R, Yakovlev, Vladimir A, Tigeeva, Elena V, Vahitov, Danil I, Sharabrin, Sergey V, Shcherbakov, Dmitriy N, Evseenko, Veronika I, Ivanova, Ksenia I, Gudymo, Andrei S, Ilyicheva, Tatiana N, Marchenko, Vasiliy Yu, Ilyichev, Alexander A, Rudometov, Andrey P, Karpenko, Larisa I

“…In this study, we characterized recombinant hemagglutinin (HA) of influenza A (H5N8) virus produced in Chinese hamster ovary cells (CHO-K1s). Immunochemical…”
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DNA Vaccine Encoding a Modified Hemagglutinin Trimer of Avian Influenza A Virus H5N8 Protects Mice from Viral Challenge by Litvinova, Victoria R, Rudometov, Andrey P, Rudometova, Nadezhda B, Kisakov, Denis N, Borgoyakova, Mariya B, Kisakova, Lyubov A, Starostina, Ekaterina V, Fando, Anastasia A, Yakovlev, Vladimir A, Tigeeva, Elena V, Ivanova, Ksenia I, Gudymo, Andrei S, Ilyicheva, Tatiana N, Marchenko, Vasiliy Yu, Sergeev, Artemiy A, Ilyichev, Alexander A, Karpenko, Larisa I

“…The development of a safe and effective vaccine against avian influenza A virus (AIV) H5N8 is relevant due to the widespread distribution of this virus in the…”
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Construction and Immunogenicity of Modified mRNA-Vaccine Variants Encoding Influenza Virus Antigens by Starostina, Ekaterina V, Sharabrin, Sergei V, Antropov, Denis N, Stepanov, Grigory A, Shevelev, Georgiy Yu, Lemza, Anna E, Rudometov, Andrey P, Borgoyakova, Mariya B, Rudometova, Nadezhda B, Marchenko, Vasiliy Yu, Danilchenko, Natalia V, Chikaev, Anton N, Bazhan, Sergei I, Ilyichev, Alexander A, Karpenko, Larisa I

“…Nucleic acid-based influenza vaccines are a promising platform that have recently and rapidly developed. We previously demonstrated the immunogenicity of DNA…”
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SARS-CoV-2 RBD Conjugated to Polyglucin, Spermidine, and dsRNA Elicits a Strong Immune Response in Mice by Volosnikova, Ekaterina A, Merkuleva, Iuliia A, Esina, Tatiana I, Shcherbakov, Dmitry N, Borgoyakova, Mariya B, Isaeva, Anastasiya A, Nesmeyanova, Valentina S, Volkova, Natalia V, Belenkaya, Svetlana V, Zaykovskaya, Anna V, Pyankov, Oleg V, Starostina, Ekaterina V, Zadorozhny, Alexey M, Zaitsev, Boris N, Karpenko, Larisa I, Ilyichev, Alexander A, Danilenko, Elena D

“…Despite the rapid development and approval of several COVID vaccines based on the full-length spike protein, there is a need for safe, potent, and high-volume…”
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Artificial Anti-HIV-1 Immunogen Comprising Epitopes of Broadly Neutralizing Antibodies 2F5, 10E8, and a Peptide Mimic of VRC01 Discontinuous Epitope by Rudometov, Andrey P, Chikaev, Anton N, Rudometova, Nadezhda B, Antonets, Denis V, Lomzov, Alexander A, Kaplina, Olga N, Ilyichev, Alexander A, Karpenko, Larisa I

“…The construction of artificial proteins using conservative B-cell and T-cell epitopes is believed to be a promising approach for a vaccine design against…”
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Artificial polyepitope HIV-1 immunogen containing mimotope of 2F5 epitope by Shcherbakova, Nadezhda S, Shcherbakov, Dmitry N, Bakulina, Anastasiya Yu, Karpenko, Larisa I, Ryzhikov, Alexander B, Ilyichev, Alexander A

“…Constructing a vaccine against HIV-1, able to induce production of broadly neutralizing antibodies, is crucial. We report here the selection and…”
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The importance of the role of T-cell immunity in the development of modern tick-borne encephalitis vaccines by Tigeeva, Elena V., Nizolenko, Lily F., Karpenko, Larisa I.

“…The tick-borne encephalitis (TBE) virus is highly pathogenic and can affect the central nervous system, leading to severe chronic effects or death. The only…”
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In silico design of influenza a virus artificial epitope-based T-cell antigens and the evaluation of their immunogenicity in mice by Bazhan, Sergei I., Antonets, Denis V., Starostina, Ekaterina V., Ilyicheva, Tatyana N., Kaplina, Olga N., Marchenko, Vasiliy Yu, Volkova, Olga Yu, Bakulina, Anastasiya Yu, Karpenko, Larisa I.

“…The polyepitope strategy is promising approach for successfully creating a broadly protective flu vaccine, which targets T-lymphocytes (both CD4+ and CD8+) to…”
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